TY - JOUR
T1 - The impact of schizophrenia on frontal perfusion parameters
T2 - A DSC-MRI study
AU - Peruzzo, Denis
AU - Rambaldelli, Gianluca
AU - Bertoldo, Alessandra
AU - Bellani, Marcella
AU - Cerini, Roberto
AU - Silvia, Marini
AU - Pozzi Mucelli, Roberto
AU - Tansella, Michele
AU - Brambilla, Paolo
PY - 2011/4
Y1 - 2011/4
N2 - We performed a dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) analysis to study the role of the demographic/clinical information on perfusion parameters between patients with schizophrenia and normal control subjects. 39 schizophrenia patients and 27 normal controls were studied with a Siemens 1.5T magnet. PWI images were obtained following intravenous injection of paramagnetic contrast agent (gadolinium-DTPA). For each perfusion parameter, i.e. relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP), the best predictor model was computed in left and right frontal cortex following a stepwise strategy. First of all, a linear model, including all the sociodemographic information and clinical variables as predictors was computed. At each step, the least significant predictor was excluded and a new linear model was evaluated until all predictors were excluded. Then, the best predictor model was selected based on the F statistic value and on the p value. The models for the rCBF and the rCBV both in the left and right frontal cortex were estimated independently from each other, and the best models contained the same predictors, i.e. clinical state, age, and length of illness. No significant models were obtained for the MTT and the TTP. This study showed a decrease in rCBF and rCBV frontal cortex values in subject affected by schizophrenia. Future DSC-MRI studies should further investigate the role of cerebral perfusion for the pathophysiology of the disease by recruiting first-episode patients and by considering cerebellar, parietal and temporal regions.
AB - We performed a dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) analysis to study the role of the demographic/clinical information on perfusion parameters between patients with schizophrenia and normal control subjects. 39 schizophrenia patients and 27 normal controls were studied with a Siemens 1.5T magnet. PWI images were obtained following intravenous injection of paramagnetic contrast agent (gadolinium-DTPA). For each perfusion parameter, i.e. relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP), the best predictor model was computed in left and right frontal cortex following a stepwise strategy. First of all, a linear model, including all the sociodemographic information and clinical variables as predictors was computed. At each step, the least significant predictor was excluded and a new linear model was evaluated until all predictors were excluded. Then, the best predictor model was selected based on the F statistic value and on the p value. The models for the rCBF and the rCBV both in the left and right frontal cortex were estimated independently from each other, and the best models contained the same predictors, i.e. clinical state, age, and length of illness. No significant models were obtained for the MTT and the TTP. This study showed a decrease in rCBF and rCBV frontal cortex values in subject affected by schizophrenia. Future DSC-MRI studies should further investigate the role of cerebral perfusion for the pathophysiology of the disease by recruiting first-episode patients and by considering cerebellar, parietal and temporal regions.
KW - Cerebral blood flow
KW - Cerebral blood volume
KW - Frontal cortex
KW - Mean transit time
KW - Perfusion imaging
KW - Time-to-peak
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U2 - 10.1007/s00702-010-0548-7
DO - 10.1007/s00702-010-0548-7
M3 - Article
C2 - 21203783
AN - SCOPUS:79956194356
VL - 118
SP - 563
EP - 570
JO - Journal of Neuro-Visceral Relations
JF - Journal of Neuro-Visceral Relations
SN - 0375-9245
IS - 4
ER -