The impact of schizophrenia on frontal perfusion parameters: A DSC-MRI study

Denis Peruzzo, Gianluca Rambaldelli, Alessandra Bertoldo, Marcella Bellani, Roberto Cerini, Marini Silvia, Roberto Pozzi Mucelli, Michele Tansella, Paolo Brambilla

Research output: Contribution to journalArticle

Abstract

We performed a dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) analysis to study the role of the demographic/clinical information on perfusion parameters between patients with schizophrenia and normal control subjects. 39 schizophrenia patients and 27 normal controls were studied with a Siemens 1.5T magnet. PWI images were obtained following intravenous injection of paramagnetic contrast agent (gadolinium-DTPA). For each perfusion parameter, i.e. relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), mean transit time (MTT) and time-to-peak (TTP), the best predictor model was computed in left and right frontal cortex following a stepwise strategy. First of all, a linear model, including all the sociodemographic information and clinical variables as predictors was computed. At each step, the least significant predictor was excluded and a new linear model was evaluated until all predictors were excluded. Then, the best predictor model was selected based on the F statistic value and on the p value. The models for the rCBF and the rCBV both in the left and right frontal cortex were estimated independently from each other, and the best models contained the same predictors, i.e. clinical state, age, and length of illness. No significant models were obtained for the MTT and the TTP. This study showed a decrease in rCBF and rCBV frontal cortex values in subject affected by schizophrenia. Future DSC-MRI studies should further investigate the role of cerebral perfusion for the pathophysiology of the disease by recruiting first-episode patients and by considering cerebellar, parietal and temporal regions.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalJournal of Neural Transmission
Volume118
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Cerebral blood flow
  • Cerebral blood volume
  • Frontal cortex
  • Mean transit time
  • Perfusion imaging
  • Time-to-peak

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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  • Cite this

    Peruzzo, D., Rambaldelli, G., Bertoldo, A., Bellani, M., Cerini, R., Silvia, M., Pozzi Mucelli, R., Tansella, M., & Brambilla, P. (2011). The impact of schizophrenia on frontal perfusion parameters: A DSC-MRI study. Journal of Neural Transmission, 118(4), 563-570. https://doi.org/10.1007/s00702-010-0548-7