The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism

I Shatynska-Mytsyk, Luis Rodrigo, Rachele Ciccocioppo, D. Petrovic, N Lakusic, Leonida Compostella, M. Novak, Peter Kruzliak

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Abstract

OBJECTIVE: Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of L-thyroxine (6.25-25 µg/day) on left ventricular diastolic function in patients with SH.

MATERIALS AND METHODS: 33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT.

RESULTS: At baseline, patients with SH showed significantly lower E (0.79 ± 0.22 vs. 0.93 ± 0.19, p < 0.001), E/A ratio (1.19 ± 0.29 vs. 1.31 ± 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 ± 0.14 vs. 0.89 ± 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 ± 0.21 vs. 1.19 ± 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 ± 0.16 vs. 0.99 ± 0.14, p < 0.001).

CONCLUSIONS: HRT with low-dosed L-thyroxine may improve left ventricular diastolic function in patients with SH.

Original languageEnglish
Pages (from-to)709-13
Number of pages5
JournalJournal of Endocrinological Investigation
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 2016

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Shatynska-Mytsyk, I., Rodrigo, L., Ciccocioppo, R., Petrovic, D., Lakusic, N., Compostella, L., Novak, M., & Kruzliak, P. (2016). The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism. Journal of Endocrinological Investigation, 39(6), 709-13. https://doi.org/10.1007/s40618-015-0262-2