The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma

Renato Talamini, Jerry Polesel, Michele Spina, Emanuela Chimienti, Diego Serraino, Antonella Zucchetto, Ernesto Zanet, Silvia Franceschi, Umberto Tirelli

Research output: Contribution to journalArticle


Tobacco smoking and alcohol consumption have not been clearly related to the risk of non-Hodgkin lymphoma (NHL), and the impact of these two factors on survival of NHL patients has received little attention. Cases were 268 subjects with incident histologically-confirmed NHL, admitted as inpatients to the Division of Medical Oncology, between 1983 and 2002. These individuals were enrolled as cases in case-control studies conducted at the same institution over the same period. For all patients clinical (histological subtype, major prognostic factors and treatment) and epidemiological data (smoking and drinking habits) were available. Survival analysis was performed using Kaplan-Meier methods. Hazard ratio (HR) was estimated by Cox proportional hazard model. Compared to never smokers, patients who smoked ≥20 cigarettes/day had higher risks of death (HR = 1.70, 95% confidence interval (CI): 1.06-2.73) and lower survivals at 5 years (60 and 46%, respectivelv). Likewise, patients who drunk ≥4 drinks/day showed 1.69-fold higher probability of death (95% CI: 1.04-2.76) in comparison to drinkers of

Original languageEnglish
Pages (from-to)1624-1629
Number of pages6
JournalInternational Journal of Cancer
Issue number7
Publication statusPublished - Apr 1 2008


  • Alcohol drinking: survival
  • Non-Hodgkin lymphoma
  • Tobacco smoking

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)
  • Oncology

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