TY - JOUR
T1 - The implications and management of septic acute kidney injury
AU - Ricci, Zaccaria
AU - Polito, Andrea
AU - Polito, Angelo
AU - Ronco, Claudio
PY - 2011/4
Y1 - 2011/4
N2 - Sepsis is the most common and severe cause of morbidity and mortality among critically ill patients. Multiple organ dysfunction syndrome often complicates sepsis, leading to a worse prognosis that is proportional to the severity and number of damaged organs. Acute kidney injury (AKI) also complicates sepsis, with a linear relationship between the severity of kidney damage and sepsis prognosis. The management of sepsis and septic AKI involves intensive proactive preventive measures, medical and extracorporeal treatment of established sepsis, support of failing organs and rehabilitation of the residual effects left by this devastating syndrome. Unfortunately, although some innovations in the clinical management of sepsis are now available, their beneficial effects on renal function are still uncertain. The aim of this Review is to provide an update on the current state of interventions in sepsis-related AKI. Prevention, pharmacological support and extracorporeal blood purification for septic AKI will be reviewed and discussed.
AB - Sepsis is the most common and severe cause of morbidity and mortality among critically ill patients. Multiple organ dysfunction syndrome often complicates sepsis, leading to a worse prognosis that is proportional to the severity and number of damaged organs. Acute kidney injury (AKI) also complicates sepsis, with a linear relationship between the severity of kidney damage and sepsis prognosis. The management of sepsis and septic AKI involves intensive proactive preventive measures, medical and extracorporeal treatment of established sepsis, support of failing organs and rehabilitation of the residual effects left by this devastating syndrome. Unfortunately, although some innovations in the clinical management of sepsis are now available, their beneficial effects on renal function are still uncertain. The aim of this Review is to provide an update on the current state of interventions in sepsis-related AKI. Prevention, pharmacological support and extracorporeal blood purification for septic AKI will be reviewed and discussed.
UR - http://www.scopus.com/inward/record.url?scp=79953169925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953169925&partnerID=8YFLogxK
U2 - 10.1038/nrneph.2011.15
DO - 10.1038/nrneph.2011.15
M3 - Article
C2 - 21364519
AN - SCOPUS:79953169925
VL - 7
SP - 218
EP - 225
JO - Nature Reviews Nephrology
JF - Nature Reviews Nephrology
SN - 1759-507X
IS - 4
ER -