Abstract
The KBB acid elution test is used to assess the presence and extent of transplacental passage of fetal cells into the maternal circulation both as a diagnostic aid in detecting hemorrhage before birth and in monitoring pregnancies at risk for hemolytic disease of the newborn. However the technique is ineffective when an hereditary Hb-pathy with associated increase in HbF is present in the mother, like the HPFH, delta-beta thalassemia and other hereditary abnormal hemoglobins. A mother with HPFH and another mother with delta-beta thalassemia with false positive result of the acid-elution test are described and the need for an extension of the clinical and laboratory study in families with hereditary HbF disorder is stressed.
Translated title of the contribution | The importance and limits of laboratory tests for evaluating the transplacental passage of fetal erythrocytes into the maternal circulation |
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Original language | Italian |
Pages (from-to) | 391-394 |
Number of pages | 4 |
Journal | Minerva Ginecologica |
Volume | 45 |
Issue number | 9 |
Publication status | Published - Sep 1993 |
ASJC Scopus subject areas
- Obstetrics and Gynaecology