The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk

Stefano Masi, Georgios Georgiopoulos, Martina Chiriacò, Guido Grassi, Gino Seravalle, Carmine Savoia, Massimo Volpe, Stefano Taddei, Damiano Rizzoni, Agostino Virdis

Research output: Contribution to journalArticle

Abstract

AIMS: The relationship between resistance artery remodelling and endothelial function remains unknown. In this study, we assessed (i) the capacity of endothelial function and nitric oxide (NO) availability to provide more information on the severity of resistance artery remodelling than common cardiovascular risk factors in subjects at low or high cardiovascular risk; and (ii) differences between patterns of resistance artery remodelling associated with deficit of NO availability and with exposure to cardiovascular risk factors.

METHODS AND RESULTS: All analyses were conducted on the microvascular data set of the Italian Society for Arterial Hypertension (SIIA) that includes 356 patients with measures of small resistance arteries remodelling acquired with pressure or wire myography. Information on endothelial function and NO availability were also available in 116 patients. The European Heart Score (HS) was used to define the total cardiovascular risk of each patient. Endothelial function was inversely related with the severity of the resistance artery remodelling, and this association remained significant after adjustment for the HS. By contrast, the HS lost its significant association with the media-to-lumen (M/L) ratio and the media cross-sectional area after adjustment for endothelial function. The strength of these associations was similar in subjects at high and low cardiovascular risk. The addition of endothelial function and NO availability to the HS significantly improved the identification of subjects at more and less severe resistance artery remodelling. A severe deficit of NO availability was associated with hypertrophic remodelling, while a higher HS was more clearly associated with eutrophic remodelling.

CONCLUSION: Resistance artery endothelial function and NO availability might represent important factors involved in resistance artery remodelling, independently from cardiovascular risk factor exposure.

Original languageEnglish
JournalCardiovascular Research
DOIs
Publication statusE-pub ahead of print - Apr 8 2019

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Arteries
Nitric Oxide
Myography
Hypertension
Pressure

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The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk. / Masi, Stefano; Georgiopoulos, Georgios; Chiriacò, Martina; Grassi, Guido; Seravalle, Gino; Savoia, Carmine; Volpe, Massimo; Taddei, Stefano; Rizzoni, Damiano; Virdis, Agostino.

In: Cardiovascular Research, 08.04.2019.

Research output: Contribution to journalArticle

Masi, Stefano ; Georgiopoulos, Georgios ; Chiriacò, Martina ; Grassi, Guido ; Seravalle, Gino ; Savoia, Carmine ; Volpe, Massimo ; Taddei, Stefano ; Rizzoni, Damiano ; Virdis, Agostino. / The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk. In: Cardiovascular Research. 2019.
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abstract = "AIMS: The relationship between resistance artery remodelling and endothelial function remains unknown. In this study, we assessed (i) the capacity of endothelial function and nitric oxide (NO) availability to provide more information on the severity of resistance artery remodelling than common cardiovascular risk factors in subjects at low or high cardiovascular risk; and (ii) differences between patterns of resistance artery remodelling associated with deficit of NO availability and with exposure to cardiovascular risk factors.METHODS AND RESULTS: All analyses were conducted on the microvascular data set of the Italian Society for Arterial Hypertension (SIIA) that includes 356 patients with measures of small resistance arteries remodelling acquired with pressure or wire myography. Information on endothelial function and NO availability were also available in 116 patients. The European Heart Score (HS) was used to define the total cardiovascular risk of each patient. Endothelial function was inversely related with the severity of the resistance artery remodelling, and this association remained significant after adjustment for the HS. By contrast, the HS lost its significant association with the media-to-lumen (M/L) ratio and the media cross-sectional area after adjustment for endothelial function. The strength of these associations was similar in subjects at high and low cardiovascular risk. The addition of endothelial function and NO availability to the HS significantly improved the identification of subjects at more and less severe resistance artery remodelling. A severe deficit of NO availability was associated with hypertrophic remodelling, while a higher HS was more clearly associated with eutrophic remodelling.CONCLUSION: Resistance artery endothelial function and NO availability might represent important factors involved in resistance artery remodelling, independently from cardiovascular risk factor exposure.",
author = "Stefano Masi and Georgios Georgiopoulos and Martina Chiriac{\`o} and Guido Grassi and Gino Seravalle and Carmine Savoia and Massimo Volpe and Stefano Taddei and Damiano Rizzoni and Agostino Virdis",
note = "Published on behalf of the European Society of Cardiology. All rights reserved. {\circledC} The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.",
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T1 - The importance of endothelial dysfunction in resistance artery remodelling and cardiovascular risk

AU - Masi, Stefano

AU - Georgiopoulos, Georgios

AU - Chiriacò, Martina

AU - Grassi, Guido

AU - Seravalle, Gino

AU - Savoia, Carmine

AU - Volpe, Massimo

AU - Taddei, Stefano

AU - Rizzoni, Damiano

AU - Virdis, Agostino

N1 - Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.

PY - 2019/4/8

Y1 - 2019/4/8

N2 - AIMS: The relationship between resistance artery remodelling and endothelial function remains unknown. In this study, we assessed (i) the capacity of endothelial function and nitric oxide (NO) availability to provide more information on the severity of resistance artery remodelling than common cardiovascular risk factors in subjects at low or high cardiovascular risk; and (ii) differences between patterns of resistance artery remodelling associated with deficit of NO availability and with exposure to cardiovascular risk factors.METHODS AND RESULTS: All analyses were conducted on the microvascular data set of the Italian Society for Arterial Hypertension (SIIA) that includes 356 patients with measures of small resistance arteries remodelling acquired with pressure or wire myography. Information on endothelial function and NO availability were also available in 116 patients. The European Heart Score (HS) was used to define the total cardiovascular risk of each patient. Endothelial function was inversely related with the severity of the resistance artery remodelling, and this association remained significant after adjustment for the HS. By contrast, the HS lost its significant association with the media-to-lumen (M/L) ratio and the media cross-sectional area after adjustment for endothelial function. The strength of these associations was similar in subjects at high and low cardiovascular risk. The addition of endothelial function and NO availability to the HS significantly improved the identification of subjects at more and less severe resistance artery remodelling. A severe deficit of NO availability was associated with hypertrophic remodelling, while a higher HS was more clearly associated with eutrophic remodelling.CONCLUSION: Resistance artery endothelial function and NO availability might represent important factors involved in resistance artery remodelling, independently from cardiovascular risk factor exposure.

AB - AIMS: The relationship between resistance artery remodelling and endothelial function remains unknown. In this study, we assessed (i) the capacity of endothelial function and nitric oxide (NO) availability to provide more information on the severity of resistance artery remodelling than common cardiovascular risk factors in subjects at low or high cardiovascular risk; and (ii) differences between patterns of resistance artery remodelling associated with deficit of NO availability and with exposure to cardiovascular risk factors.METHODS AND RESULTS: All analyses were conducted on the microvascular data set of the Italian Society for Arterial Hypertension (SIIA) that includes 356 patients with measures of small resistance arteries remodelling acquired with pressure or wire myography. Information on endothelial function and NO availability were also available in 116 patients. The European Heart Score (HS) was used to define the total cardiovascular risk of each patient. Endothelial function was inversely related with the severity of the resistance artery remodelling, and this association remained significant after adjustment for the HS. By contrast, the HS lost its significant association with the media-to-lumen (M/L) ratio and the media cross-sectional area after adjustment for endothelial function. The strength of these associations was similar in subjects at high and low cardiovascular risk. The addition of endothelial function and NO availability to the HS significantly improved the identification of subjects at more and less severe resistance artery remodelling. A severe deficit of NO availability was associated with hypertrophic remodelling, while a higher HS was more clearly associated with eutrophic remodelling.CONCLUSION: Resistance artery endothelial function and NO availability might represent important factors involved in resistance artery remodelling, independently from cardiovascular risk factor exposure.

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DO - 10.1093/cvr/cvz096

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JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

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