The in vitro induction of human immunodeficiency virus (HIV) replication in purified protein derivative-positive HIV-infected persons by recall antigen response to Mycobacterium tuberculosis is the result of a balance of the effects of endogenous interleukin-2 and proinflammatory and antiinflammatory cytokines

Delia Goletti, Drew Weissman, Robert W. Jackson, Frank Collins, Audrey Kinter, Anthony S. Fauci

Research output: Contribution to journalArticle

Abstract

Coinfection with Mycobacterium tuberculosis and human immunodeficiency virus (HIV) is a serious problem, particularly in developing countries. Recently, M. tuberculosis and purified protein derivative (PPD) were demonstrated to induce HIV replication in CD8 T cell-depleted peripheral blood mononuclear cells from HIV-positive, PPD-positive persons but not in cells from PPD-negative persons. The role of endogenous and exogenous cytokines in modulating M. tuberculosis-induced HIV replication was evaluated. M. tuberculosis-induced HIV replication decreased following simultaneous inhibition of endogenous interleukin (IL)-2, IL-1β, and tumor necrosis factor-α by the addition of soluble receptors and receptor antagonists or following exogenous IL-10 and transforming growth factor (TGF)-β. In contrast, neutralization of endogenous IL-10 and TGF-β augmented M. tuberculosis-induced HIV replication by increasing cellular activation. Thus, the balance between IL-2 and proinflammatory and antiinflammatory cytokines plays a major role in M. tuberculosis-induced replication of HIV.

Original languageEnglish
Pages (from-to)1332-1338
Number of pages7
JournalJournal of Infectious Diseases
Volume177
Issue number5
Publication statusPublished - 1998

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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