The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Antonio Rosato; Vincenzo Bronte; Francesca Pollis; Susanna Mandruzzato; Analisa Zambon; Paola Zanovello; Dino Collavo

The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Antonio Rosato, Vincenzo Bronte, Francesca Pollis, Susanna Mandruzzato, Analisa Zambon, Paola Zanovello, Dino Collavo

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interferring with CTL generation and localization in the tumor mass.

Original language	English
Journal	Leukemia
Volume	6
Issue number	SUPPL. 3
Publication status	Published - 1992

ASJC Scopus subject areas

Hematology
Cancer Research

Cite this

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title = "The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex",

abstract = "The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interferring with CTL generation and localization in the tumor mass.",

author = "Antonio Rosato and Vincenzo Bronte and Francesca Pollis and Susanna Mandruzzato and Analisa Zambon and Paola Zanovello and Dino Collavo",

year = "1992",

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AU - Rosato, Antonio

AU - Bronte, Vincenzo

AU - Pollis, Francesca

AU - Mandruzzato, Susanna

AU - Zambon, Analisa

AU - Zanovello, Paola

AU - Collavo, Dino

PY - 1992

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AB - The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interferring with CTL generation and localization in the tumor mass.

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JO - Leukemia

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ER -

The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Abstract

ASJC Scopus subject areas

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