The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Antonio Rosato, Vincenzo Bronte, Francesca Pollis, Susanna Mandruzzato, Analisa Zambon, Paola Zanovello, Dino Collavo

Research output: Contribution to journalArticlepeer-review

Abstract

The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interferring with CTL generation and localization in the tumor mass.

Original languageEnglish
JournalLeukemia
Volume6
Issue numberSUPPL. 3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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