The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Antonio Rosato; Vincenzo Bronte; Francesca Pollis; Susanna Mandruzzato; Analisa Zambon; Paola Zanovello; Dino Collavo

The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex

Antonio Rosato, Vincenzo Bronte, Francesca Pollis, Susanna Mandruzzato, Analisa Zambon, Paola Zanovello, Dino Collavo

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interferring with CTL generation and localization in the tumor mass.

Original language	English
Journal	Leukemia
Volume	6
Issue number	SUPPL. 3
Publication status	Published - 1992

ASJC Scopus subject areas

Hematology
Cancer Research

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The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex. / Rosato, Antonio; Bronte, Vincenzo; Pollis, Francesca; Mandruzzato, Susanna; Zambon, Analisa; Zanovello, Paola; Collavo, Dino.

In: Leukemia, Vol. 6, No. SUPPL. 3, 1992.

Research output: Contribution to journal › Article › peer-review

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