The incidental finding of elevated anti GQ1B antibodies in a patient with selective small fiber neuropathy

Valentina Favoni, Rocco Liguori, Alex Incensi, Enrico Fileccia, Vincenzo Donadio

Research output: Contribution to journalLetterpeer-review

Abstract

Small fiber neuropathy (SFN) selectively affects small diameter sensory and/or autonomic axons. Pain and autonomic dysfunctions are the most common symptoms. SFN occurs in several autoimmune diseases and autoantibodies against neuronal proteins may play a role in SFN pathophysiology. Anti-GQ1b antibody has been associated with Miller Fisher syndrome, Bickerstaff's brainstem encephalitis, acute ophthalmoplegia, pharyngeal-cervical-brachial weakness and peripheral neuropathy involving large fibers. Isolated SFN associated with anti-GQ1b antibodies has not been previously reported. Here we report a 45-year-old woman presenting with highly positive anti-GQ1b titer and selective SFN without central nervous system or peripheral large nerve involvement. She improved upon administration of adalizumab. Further studies will clarify a possible pathogenetic role of antiganglioside antibodies in SFN. Moreover, the recognition of antiganglioside antibodies in SFN may have therapeutic consequences with patients who would benefit from immunotherapy.

Original languageEnglish
Pages (from-to)192-194
Number of pages3
JournalJournal of the Neurological Sciences
Volume388
DOIs
Publication statusPublished - May 15 2018

Keywords

  • Anti-GQ1b
  • Autoimmune diseases
  • Skin biopsy
  • Small fiber neuropathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'The incidental finding of elevated anti GQ1B antibodies in a patient with selective small fiber neuropathy'. Together they form a unique fingerprint.

Cite this