The inflammatory protein Pentraxin 3 in cardiovascular disease

Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Letizia Busceti, Annibale Alessandro Puca, Carmine Vecchione

Research output: Contribution to journalArticle

Abstract

The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients. In the present review, we discuss the multifaceted effects of PTX3 on the cardiovascular system focusing on its involvement in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis. This may help to explain how the specific modulation of PTX3 such as the use of different dosing, time, and target organs could help to contain different vascular diseases. These opposite actions of PTX3 will be emphasized concerning the modulation of cardiovascular system where potential therapeutic implications of PTX3 in humans are discussed.

Original languageEnglish
Article number25
JournalImmunity and Ageing
Volume13
Issue number1
DOIs
Publication statusPublished - Aug 24 2016

Keywords

  • Acute phase protein of inflammation
  • Angiogenesis
  • Atherosclerosis
  • Cardiovascular diseases
  • Myocardial infarction
  • Pentraxin 3

ASJC Scopus subject areas

  • Immunology
  • Ageing

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  • Cite this

    Fornai, F., Carrizzo, A., Forte, M., Ambrosio, M., Damato, A., Ferrucci, M., Biagioni, F., Busceti, C. L., Puca, A. A., & Vecchione, C. (2016). The inflammatory protein Pentraxin 3 in cardiovascular disease. Immunity and Ageing, 13(1), [25]. https://doi.org/10.1186/s12979-016-0080-1