The inflammatory response system in treatment-resistant schizophrenia: Increased serum interleukin-6

A. Lin, G. Kenis, S. Bignotti, G. J B Tura, R. De Jong, E. Bosmans, R. Pioli, C. Altamura, S. Scharpé, M. Maes

Research output: Contribution to journalArticle

Abstract

There is some evidence that the pathophysiology of schizophrenia is related to activation of the inflammatory response system (IRS), as indicated by increased serum concentrations of interleukin-6 (IL-6), IL-6 receptor (IL- 6R), IL-1R antagonist (IL-1RA) and IL-2R and lower serum concentrations of CC16, an endogenous anti-inflammatory protein with immunosuppressive and anti-inflammatory effects. The aims of the present study were to examine serum CC16 in relation to IL-6, IL-6R and gp130, the IL-6 transducing signal protein, in schizophrenia and in treatment-resistant schizophrenia (TRS). Serum IL-6 and sIL-6R were significantly higher in medicated schizophrenic patients than in normal controls. Serum IL-6 was significantly higher in TRS than in normal volunteers, whereas schizophrenic patients without TRS showed intermediate values. Serum CC16 was significantly lower in schizophrenic patients with a positive family history for psychoses than in normal volunteers and patients without a positive family history. There was a significant inverse relationship between serum CC16 and serum IL-6 or sIL-6R in schizophrenic patients, but not in normal volunteers. The results suggest that the inflammatory response in schizophrenia, as indicated by increased serum IL-6 and sIL-6R, may be causally related to lower serum CC16 and that the latter might be a trait marker for schizophrenia.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalSchizophrenia Research
Volume32
Issue number1
DOIs
Publication statusPublished - Jun 22 1998

Fingerprint

Interleukin-6
Schizophrenia
Serum
Therapeutics
Healthy Volunteers
Anti-Inflammatory Agents
Interleukin-6 Receptors
Immunosuppressive Agents
Psychotic Disorders
Proteins

Keywords

  • CC16
  • Cytokines
  • Inflammation
  • Interleukin-6
  • Neuroleptics
  • Treatment- resistant schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Lin, A., Kenis, G., Bignotti, S., Tura, G. J. B., De Jong, R., Bosmans, E., ... Maes, M. (1998). The inflammatory response system in treatment-resistant schizophrenia: Increased serum interleukin-6. Schizophrenia Research, 32(1), 9-15. https://doi.org/10.1016/S0920-9964(98)00034-6

The inflammatory response system in treatment-resistant schizophrenia : Increased serum interleukin-6. / Lin, A.; Kenis, G.; Bignotti, S.; Tura, G. J B; De Jong, R.; Bosmans, E.; Pioli, R.; Altamura, C.; Scharpé, S.; Maes, M.

In: Schizophrenia Research, Vol. 32, No. 1, 22.06.1998, p. 9-15.

Research output: Contribution to journalArticle

Lin, A, Kenis, G, Bignotti, S, Tura, GJB, De Jong, R, Bosmans, E, Pioli, R, Altamura, C, Scharpé, S & Maes, M 1998, 'The inflammatory response system in treatment-resistant schizophrenia: Increased serum interleukin-6', Schizophrenia Research, vol. 32, no. 1, pp. 9-15. https://doi.org/10.1016/S0920-9964(98)00034-6
Lin, A. ; Kenis, G. ; Bignotti, S. ; Tura, G. J B ; De Jong, R. ; Bosmans, E. ; Pioli, R. ; Altamura, C. ; Scharpé, S. ; Maes, M. / The inflammatory response system in treatment-resistant schizophrenia : Increased serum interleukin-6. In: Schizophrenia Research. 1998 ; Vol. 32, No. 1. pp. 9-15.
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