The influence of alcohol consumption on the risk of vertebral deformity

M. Naves Diaz, T. W. O'Neill, A. J. Silman, D. Agnusdei, K. Bergmann, C. Cooper, J. Dequeker, D. Felsenberg, J. A. Kanis, G. Kruskemper, H. Raspe, J. Varlow, D. Marsden, D. Felsenberg, E. Wieland, L. Kalidis, J. Mews, T. Lauermann, K. Weber, J. Dequeker & 58 others P. Geusens, I. Jajic, S. Havelka, P. Vavrincova, P. D. Delmas, F. Marchand, D. Felsenberg, D. Banzer, S. Kirschner, W. Reisinger, J. Janott, H. Schatz, J. Franke, C. Scheidt-Nave, R. Ziegler, K. Abendroth, B. Felsch, C. Matthis, H. Raspe, A. Antoniou, G. Lyritis, C. Kiss, G. Poor, D. Agnusdei, C. Gennari, S. Ortolani, A. Hofman, H. A P Pols, J. A. Falch, H. E. Meyer, S. Czekalski, T. Miazgowski, K. Hoszowski, R. S. Lorenc, A. Aroso, A. Lopez Vaz, L. I. Benevolenskaya, E. E. Mikhailov, A. Letkovska, P. Masaryk, D. Roig Escofet, M. Ruiz Martin, M. Sosa, M. Diaz Curiel, A. Rapado, J. B. Cannata Andia, J. B. Diaz Lopez, O. Johnell, B. Nilsson, G. Dilsen, D. M. Reid, A. K. Bhalla, F. Ring, C. Todd, R. Williams, J. Reeve, R. Eastell, A. D. Woolf

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The influence of alcohol consumption on the risk of osteoporosis is not well established. The aim of this study was to determine the relationship between frequency of alcohol consumption and the risk of vertebral deformity across different European populations. A population survey method was used. Men and women aged 50 years and over were recruited from population-based sampling frames in 35 centres from 19 European countries. Subjects were invited to attend by letter of invitation for an interviewer-administered questionnaire and lateral spinal radiographs. Vertebral deformity was defined morphometrically using the McCloskey-Kanis method. Data from 14237 individuals were available for this analysis. Alcohol consumption was compared between the 809 men and 884 women with vertebral deformity and the 5905 men and 6639 women without vertebral deformity. The frequency of alcohol intake was greater in men than women. Overall, there was no detectable association between frequency of alcohol intake and vertebral deformity in either men or women. Stratification by age showed that women 65 years and over who took alcohol on more than 5 days per week had a reduced risk of vertebral deformity compared with those taking alcohol less than once per week. This protection was most obvious after adjusting for age, centre, body mass index, smoking, current level of physical activity and previous fractures (odds ratio [OR] 0.65; 95% confidence intervals [CI] 0.43, 0.99). There was a smaller and non-significant protective effect amongst men aged 65 years and over and this was most apparent amongst moderately frequent drinkers (1-4 days per week) (OR = 0.81; 95% CI = 0.62, 1.08). There was no association between the occurrence of vertebral deformity and frequency of alcohol consumption in younger men and women. Overall, the effects of the frequency of alcohol consumption on vertebral deformity were modest. In older women, regular consumption on more than 5 days per week is associated with a reduced risk. Further, prospective data are required to confirm these findings. It is also necessary to investigate, in terms of amount of alcohol consumed, at what level the benefits of regular intake are obviated by the increased risks from alcohol excess.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalOsteoporosis International
Volume7
Issue number1
DOIs
Publication statusPublished - 1997

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Alcohol Drinking
Alcohols
Odds Ratio
Confidence Intervals
Population
Osteoporosis
Body Mass Index
Smoking
Interviews
Exercise

Keywords

  • Alcohol consumption
  • Multicentre study
  • Osteoporosis
  • Vertebral deformity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Naves Diaz, M., O'Neill, T. W., Silman, A. J., Agnusdei, D., Bergmann, K., Cooper, C., ... Woolf, A. D. (1997). The influence of alcohol consumption on the risk of vertebral deformity. Osteoporosis International, 7(1), 65-71. https://doi.org/10.1007/BF01623463

The influence of alcohol consumption on the risk of vertebral deformity. / Naves Diaz, M.; O'Neill, T. W.; Silman, A. J.; Agnusdei, D.; Bergmann, K.; Cooper, C.; Dequeker, J.; Felsenberg, D.; Kanis, J. A.; Kruskemper, G.; Raspe, H.; Varlow, J.; Marsden, D.; Felsenberg, D.; Wieland, E.; Kalidis, L.; Mews, J.; Lauermann, T.; Weber, K.; Dequeker, J.; Geusens, P.; Jajic, I.; Havelka, S.; Vavrincova, P.; Delmas, P. D.; Marchand, F.; Felsenberg, D.; Banzer, D.; Kirschner, S.; Reisinger, W.; Janott, J.; Schatz, H.; Franke, J.; Scheidt-Nave, C.; Ziegler, R.; Abendroth, K.; Felsch, B.; Matthis, C.; Raspe, H.; Antoniou, A.; Lyritis, G.; Kiss, C.; Poor, G.; Agnusdei, D.; Gennari, C.; Ortolani, S.; Hofman, A.; Pols, H. A P; Falch, J. A.; Meyer, H. E.; Czekalski, S.; Miazgowski, T.; Hoszowski, K.; Lorenc, R. S.; Aroso, A.; Lopez Vaz, A.; Benevolenskaya, L. I.; Mikhailov, E. E.; Letkovska, A.; Masaryk, P.; Roig Escofet, D.; Ruiz Martin, M.; Sosa, M.; Diaz Curiel, M.; Rapado, A.; Cannata Andia, J. B.; Diaz Lopez, J. B.; Johnell, O.; Nilsson, B.; Dilsen, G.; Reid, D. M.; Bhalla, A. K.; Ring, F.; Todd, C.; Williams, R.; Reeve, J.; Eastell, R.; Woolf, A. D.

In: Osteoporosis International, Vol. 7, No. 1, 1997, p. 65-71.

Research output: Contribution to journalArticle

Naves Diaz, M, O'Neill, TW, Silman, AJ, Agnusdei, D, Bergmann, K, Cooper, C, Dequeker, J, Felsenberg, D, Kanis, JA, Kruskemper, G, Raspe, H, Varlow, J, Marsden, D, Felsenberg, D, Wieland, E, Kalidis, L, Mews, J, Lauermann, T, Weber, K, Dequeker, J, Geusens, P, Jajic, I, Havelka, S, Vavrincova, P, Delmas, PD, Marchand, F, Felsenberg, D, Banzer, D, Kirschner, S, Reisinger, W, Janott, J, Schatz, H, Franke, J, Scheidt-Nave, C, Ziegler, R, Abendroth, K, Felsch, B, Matthis, C, Raspe, H, Antoniou, A, Lyritis, G, Kiss, C, Poor, G, Agnusdei, D, Gennari, C, Ortolani, S, Hofman, A, Pols, HAP, Falch, JA, Meyer, HE, Czekalski, S, Miazgowski, T, Hoszowski, K, Lorenc, RS, Aroso, A, Lopez Vaz, A, Benevolenskaya, LI, Mikhailov, EE, Letkovska, A, Masaryk, P, Roig Escofet, D, Ruiz Martin, M, Sosa, M, Diaz Curiel, M, Rapado, A, Cannata Andia, JB, Diaz Lopez, JB, Johnell, O, Nilsson, B, Dilsen, G, Reid, DM, Bhalla, AK, Ring, F, Todd, C, Williams, R, Reeve, J, Eastell, R & Woolf, AD 1997, 'The influence of alcohol consumption on the risk of vertebral deformity', Osteoporosis International, vol. 7, no. 1, pp. 65-71. https://doi.org/10.1007/BF01623463
Naves Diaz M, O'Neill TW, Silman AJ, Agnusdei D, Bergmann K, Cooper C et al. The influence of alcohol consumption on the risk of vertebral deformity. Osteoporosis International. 1997;7(1):65-71. https://doi.org/10.1007/BF01623463
Naves Diaz, M. ; O'Neill, T. W. ; Silman, A. J. ; Agnusdei, D. ; Bergmann, K. ; Cooper, C. ; Dequeker, J. ; Felsenberg, D. ; Kanis, J. A. ; Kruskemper, G. ; Raspe, H. ; Varlow, J. ; Marsden, D. ; Felsenberg, D. ; Wieland, E. ; Kalidis, L. ; Mews, J. ; Lauermann, T. ; Weber, K. ; Dequeker, J. ; Geusens, P. ; Jajic, I. ; Havelka, S. ; Vavrincova, P. ; Delmas, P. D. ; Marchand, F. ; Felsenberg, D. ; Banzer, D. ; Kirschner, S. ; Reisinger, W. ; Janott, J. ; Schatz, H. ; Franke, J. ; Scheidt-Nave, C. ; Ziegler, R. ; Abendroth, K. ; Felsch, B. ; Matthis, C. ; Raspe, H. ; Antoniou, A. ; Lyritis, G. ; Kiss, C. ; Poor, G. ; Agnusdei, D. ; Gennari, C. ; Ortolani, S. ; Hofman, A. ; Pols, H. A P ; Falch, J. A. ; Meyer, H. E. ; Czekalski, S. ; Miazgowski, T. ; Hoszowski, K. ; Lorenc, R. S. ; Aroso, A. ; Lopez Vaz, A. ; Benevolenskaya, L. I. ; Mikhailov, E. E. ; Letkovska, A. ; Masaryk, P. ; Roig Escofet, D. ; Ruiz Martin, M. ; Sosa, M. ; Diaz Curiel, M. ; Rapado, A. ; Cannata Andia, J. B. ; Diaz Lopez, J. B. ; Johnell, O. ; Nilsson, B. ; Dilsen, G. ; Reid, D. M. ; Bhalla, A. K. ; Ring, F. ; Todd, C. ; Williams, R. ; Reeve, J. ; Eastell, R. ; Woolf, A. D. / The influence of alcohol consumption on the risk of vertebral deformity. In: Osteoporosis International. 1997 ; Vol. 7, No. 1. pp. 65-71.
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title = "The influence of alcohol consumption on the risk of vertebral deformity",
abstract = "The influence of alcohol consumption on the risk of osteoporosis is not well established. The aim of this study was to determine the relationship between frequency of alcohol consumption and the risk of vertebral deformity across different European populations. A population survey method was used. Men and women aged 50 years and over were recruited from population-based sampling frames in 35 centres from 19 European countries. Subjects were invited to attend by letter of invitation for an interviewer-administered questionnaire and lateral spinal radiographs. Vertebral deformity was defined morphometrically using the McCloskey-Kanis method. Data from 14237 individuals were available for this analysis. Alcohol consumption was compared between the 809 men and 884 women with vertebral deformity and the 5905 men and 6639 women without vertebral deformity. The frequency of alcohol intake was greater in men than women. Overall, there was no detectable association between frequency of alcohol intake and vertebral deformity in either men or women. Stratification by age showed that women 65 years and over who took alcohol on more than 5 days per week had a reduced risk of vertebral deformity compared with those taking alcohol less than once per week. This protection was most obvious after adjusting for age, centre, body mass index, smoking, current level of physical activity and previous fractures (odds ratio [OR] 0.65; 95{\%} confidence intervals [CI] 0.43, 0.99). There was a smaller and non-significant protective effect amongst men aged 65 years and over and this was most apparent amongst moderately frequent drinkers (1-4 days per week) (OR = 0.81; 95{\%} CI = 0.62, 1.08). There was no association between the occurrence of vertebral deformity and frequency of alcohol consumption in younger men and women. Overall, the effects of the frequency of alcohol consumption on vertebral deformity were modest. In older women, regular consumption on more than 5 days per week is associated with a reduced risk. Further, prospective data are required to confirm these findings. It is also necessary to investigate, in terms of amount of alcohol consumed, at what level the benefits of regular intake are obviated by the increased risks from alcohol excess.",
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doi = "10.1007/BF01623463",
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journal = "Osteoporosis International",
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TY - JOUR

T1 - The influence of alcohol consumption on the risk of vertebral deformity

AU - Naves Diaz, M.

AU - O'Neill, T. W.

AU - Silman, A. J.

AU - Agnusdei, D.

AU - Bergmann, K.

AU - Cooper, C.

AU - Dequeker, J.

AU - Felsenberg, D.

AU - Kanis, J. A.

AU - Kruskemper, G.

AU - Raspe, H.

AU - Varlow, J.

AU - Marsden, D.

AU - Felsenberg, D.

AU - Wieland, E.

AU - Kalidis, L.

AU - Mews, J.

AU - Lauermann, T.

AU - Weber, K.

AU - Dequeker, J.

AU - Geusens, P.

AU - Jajic, I.

AU - Havelka, S.

AU - Vavrincova, P.

AU - Delmas, P. D.

AU - Marchand, F.

AU - Felsenberg, D.

AU - Banzer, D.

AU - Kirschner, S.

AU - Reisinger, W.

AU - Janott, J.

AU - Schatz, H.

AU - Franke, J.

AU - Scheidt-Nave, C.

AU - Ziegler, R.

AU - Abendroth, K.

AU - Felsch, B.

AU - Matthis, C.

AU - Raspe, H.

AU - Antoniou, A.

AU - Lyritis, G.

AU - Kiss, C.

AU - Poor, G.

AU - Agnusdei, D.

AU - Gennari, C.

AU - Ortolani, S.

AU - Hofman, A.

AU - Pols, H. A P

AU - Falch, J. A.

AU - Meyer, H. E.

AU - Czekalski, S.

AU - Miazgowski, T.

AU - Hoszowski, K.

AU - Lorenc, R. S.

AU - Aroso, A.

AU - Lopez Vaz, A.

AU - Benevolenskaya, L. I.

AU - Mikhailov, E. E.

AU - Letkovska, A.

AU - Masaryk, P.

AU - Roig Escofet, D.

AU - Ruiz Martin, M.

AU - Sosa, M.

AU - Diaz Curiel, M.

AU - Rapado, A.

AU - Cannata Andia, J. B.

AU - Diaz Lopez, J. B.

AU - Johnell, O.

AU - Nilsson, B.

AU - Dilsen, G.

AU - Reid, D. M.

AU - Bhalla, A. K.

AU - Ring, F.

AU - Todd, C.

AU - Williams, R.

AU - Reeve, J.

AU - Eastell, R.

AU - Woolf, A. D.

PY - 1997

Y1 - 1997

N2 - The influence of alcohol consumption on the risk of osteoporosis is not well established. The aim of this study was to determine the relationship between frequency of alcohol consumption and the risk of vertebral deformity across different European populations. A population survey method was used. Men and women aged 50 years and over were recruited from population-based sampling frames in 35 centres from 19 European countries. Subjects were invited to attend by letter of invitation for an interviewer-administered questionnaire and lateral spinal radiographs. Vertebral deformity was defined morphometrically using the McCloskey-Kanis method. Data from 14237 individuals were available for this analysis. Alcohol consumption was compared between the 809 men and 884 women with vertebral deformity and the 5905 men and 6639 women without vertebral deformity. The frequency of alcohol intake was greater in men than women. Overall, there was no detectable association between frequency of alcohol intake and vertebral deformity in either men or women. Stratification by age showed that women 65 years and over who took alcohol on more than 5 days per week had a reduced risk of vertebral deformity compared with those taking alcohol less than once per week. This protection was most obvious after adjusting for age, centre, body mass index, smoking, current level of physical activity and previous fractures (odds ratio [OR] 0.65; 95% confidence intervals [CI] 0.43, 0.99). There was a smaller and non-significant protective effect amongst men aged 65 years and over and this was most apparent amongst moderately frequent drinkers (1-4 days per week) (OR = 0.81; 95% CI = 0.62, 1.08). There was no association between the occurrence of vertebral deformity and frequency of alcohol consumption in younger men and women. Overall, the effects of the frequency of alcohol consumption on vertebral deformity were modest. In older women, regular consumption on more than 5 days per week is associated with a reduced risk. Further, prospective data are required to confirm these findings. It is also necessary to investigate, in terms of amount of alcohol consumed, at what level the benefits of regular intake are obviated by the increased risks from alcohol excess.

AB - The influence of alcohol consumption on the risk of osteoporosis is not well established. The aim of this study was to determine the relationship between frequency of alcohol consumption and the risk of vertebral deformity across different European populations. A population survey method was used. Men and women aged 50 years and over were recruited from population-based sampling frames in 35 centres from 19 European countries. Subjects were invited to attend by letter of invitation for an interviewer-administered questionnaire and lateral spinal radiographs. Vertebral deformity was defined morphometrically using the McCloskey-Kanis method. Data from 14237 individuals were available for this analysis. Alcohol consumption was compared between the 809 men and 884 women with vertebral deformity and the 5905 men and 6639 women without vertebral deformity. The frequency of alcohol intake was greater in men than women. Overall, there was no detectable association between frequency of alcohol intake and vertebral deformity in either men or women. Stratification by age showed that women 65 years and over who took alcohol on more than 5 days per week had a reduced risk of vertebral deformity compared with those taking alcohol less than once per week. This protection was most obvious after adjusting for age, centre, body mass index, smoking, current level of physical activity and previous fractures (odds ratio [OR] 0.65; 95% confidence intervals [CI] 0.43, 0.99). There was a smaller and non-significant protective effect amongst men aged 65 years and over and this was most apparent amongst moderately frequent drinkers (1-4 days per week) (OR = 0.81; 95% CI = 0.62, 1.08). There was no association between the occurrence of vertebral deformity and frequency of alcohol consumption in younger men and women. Overall, the effects of the frequency of alcohol consumption on vertebral deformity were modest. In older women, regular consumption on more than 5 days per week is associated with a reduced risk. Further, prospective data are required to confirm these findings. It is also necessary to investigate, in terms of amount of alcohol consumed, at what level the benefits of regular intake are obviated by the increased risks from alcohol excess.

KW - Alcohol consumption

KW - Multicentre study

KW - Osteoporosis

KW - Vertebral deformity

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