The influence of body mass index on the oxygen uptake efficiency slope in patients with heart failure

Ross Arena, Jonathan Myers, Joshua Abella, Mary Ann Peberdy, Daniel Bensimhon, Paul Chase, Marco Guazzi

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There does not appear to be a relationship between peak oxygen consumption (VO2) and body mass index (BMI) in patients with heart failure (HF). We assessed the hypothesis that BMI and the oxygen uptake efficiency slope (OUES) would be related. Three hundred and thirty-seven HF patients (280 male/57 female, mean age: 56.5 ± 14.1 years, resting left ventricular ejection fraction: 35.1 ± 14.2%, BMI: 29.3 ± 6.2 kg/m2) underwent cardiopulmonary exercise testing where peak VO2 and the OUES (VO2 = a log10VE + b, units: L/min) were determined. Pearson product moment correlation analysis revealed that the correlation between BMI and the OUES was significant (r = 0.32, p <0.001). Furthermore, the OUES was prognostically significant in normal weight (optimal threshold: ≤/> 1.2, hazard ratio: 3.7, 95% confidence interval: 1.4-9.9, p = 0.01), overweight (optimal threshold: ≤/> 1.5, hazard ratio: 3.9, 95% confidence interval: 1.3-11.1, p = 0.01) and obese (optimal threshold: ≤/> 1.7, hazard ratio: 4.1, 95% confidence interval: 1.4-12.8, p = 0.01) subgroups. The OUES appears to improve with body weight in patients with HF. Furthermore, the OUES appears to be a significant prognostic marker irrespective of BMI although the optimal threshold value may differ according to body weight.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - Apr 10 2008


  • Exercise testing
  • Prognosis
  • Ventilatory expired gas

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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