Abstract
There does not appear to be a relationship between peak oxygen consumption (VO2) and body mass index (BMI) in patients with heart failure (HF). We assessed the hypothesis that BMI and the oxygen uptake efficiency slope (OUES) would be related. Three hundred and thirty-seven HF patients (280 male/57 female, mean age: 56.5 ± 14.1 years, resting left ventricular ejection fraction: 35.1 ± 14.2%, BMI: 29.3 ± 6.2 kg/m2) underwent cardiopulmonary exercise testing where peak VO2 and the OUES (VO2 = a log10VE + b, units: L/min) were determined. Pearson product moment correlation analysis revealed that the correlation between BMI and the OUES was significant (r = 0.32, p <0.001). Furthermore, the OUES was prognostically significant in normal weight (optimal threshold: ≤/> 1.2, hazard ratio: 3.7, 95% confidence interval: 1.4-9.9, p = 0.01), overweight (optimal threshold: ≤/> 1.5, hazard ratio: 3.9, 95% confidence interval: 1.3-11.1, p = 0.01) and obese (optimal threshold: ≤/> 1.7, hazard ratio: 4.1, 95% confidence interval: 1.4-12.8, p = 0.01) subgroups. The OUES appears to improve with body weight in patients with HF. Furthermore, the OUES appears to be a significant prognostic marker irrespective of BMI although the optimal threshold value may differ according to body weight.
| Original language | English |
|---|---|
| Pages (from-to) | 270-272 |
| Number of pages | 3 |
| Journal | International Journal of Cardiology |
| Volume | 125 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 10 2008 |
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Keywords
- Exercise testing
- Prognosis
- Ventilatory expired gas
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The influence of body mass index on the oxygen uptake efficiency slope in patients with heart failure. / Arena, Ross; Myers, Jonathan; Abella, Joshua; Peberdy, Mary Ann; Bensimhon, Daniel; Chase, Paul; Guazzi, Marco.
In: International Journal of Cardiology, Vol. 125, No. 2, 10.04.2008, p. 270-272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The influence of body mass index on the oxygen uptake efficiency slope in patients with heart failure
AU - Arena, Ross
AU - Myers, Jonathan
AU - Abella, Joshua
AU - Peberdy, Mary Ann
AU - Bensimhon, Daniel
AU - Chase, Paul
AU - Guazzi, Marco
PY - 2008/4/10
Y1 - 2008/4/10
N2 - There does not appear to be a relationship between peak oxygen consumption (VO2) and body mass index (BMI) in patients with heart failure (HF). We assessed the hypothesis that BMI and the oxygen uptake efficiency slope (OUES) would be related. Three hundred and thirty-seven HF patients (280 male/57 female, mean age: 56.5 ± 14.1 years, resting left ventricular ejection fraction: 35.1 ± 14.2%, BMI: 29.3 ± 6.2 kg/m2) underwent cardiopulmonary exercise testing where peak VO2 and the OUES (VO2 = a log10VE + b, units: L/min) were determined. Pearson product moment correlation analysis revealed that the correlation between BMI and the OUES was significant (r = 0.32, p <0.001). Furthermore, the OUES was prognostically significant in normal weight (optimal threshold: ≤/> 1.2, hazard ratio: 3.7, 95% confidence interval: 1.4-9.9, p = 0.01), overweight (optimal threshold: ≤/> 1.5, hazard ratio: 3.9, 95% confidence interval: 1.3-11.1, p = 0.01) and obese (optimal threshold: ≤/> 1.7, hazard ratio: 4.1, 95% confidence interval: 1.4-12.8, p = 0.01) subgroups. The OUES appears to improve with body weight in patients with HF. Furthermore, the OUES appears to be a significant prognostic marker irrespective of BMI although the optimal threshold value may differ according to body weight.
AB - There does not appear to be a relationship between peak oxygen consumption (VO2) and body mass index (BMI) in patients with heart failure (HF). We assessed the hypothesis that BMI and the oxygen uptake efficiency slope (OUES) would be related. Three hundred and thirty-seven HF patients (280 male/57 female, mean age: 56.5 ± 14.1 years, resting left ventricular ejection fraction: 35.1 ± 14.2%, BMI: 29.3 ± 6.2 kg/m2) underwent cardiopulmonary exercise testing where peak VO2 and the OUES (VO2 = a log10VE + b, units: L/min) were determined. Pearson product moment correlation analysis revealed that the correlation between BMI and the OUES was significant (r = 0.32, p <0.001). Furthermore, the OUES was prognostically significant in normal weight (optimal threshold: ≤/> 1.2, hazard ratio: 3.7, 95% confidence interval: 1.4-9.9, p = 0.01), overweight (optimal threshold: ≤/> 1.5, hazard ratio: 3.9, 95% confidence interval: 1.3-11.1, p = 0.01) and obese (optimal threshold: ≤/> 1.7, hazard ratio: 4.1, 95% confidence interval: 1.4-12.8, p = 0.01) subgroups. The OUES appears to improve with body weight in patients with HF. Furthermore, the OUES appears to be a significant prognostic marker irrespective of BMI although the optimal threshold value may differ according to body weight.
KW - Exercise testing
KW - Prognosis
KW - Ventilatory expired gas
UR - http://www.scopus.com/inward/record.url?scp=40849147027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40849147027&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2007.11.013
DO - 10.1016/j.ijcard.2007.11.013
M3 - Article
C2 - 18234369
AN - SCOPUS:40849147027
VL - 125
SP - 270
EP - 272
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -