The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males: an observational study of 615 subjects

Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone

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Abstract

BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis.

DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery.

METHODS: 615 males (mean age ± SD: 40.8±9.8 years) without overt atherosclerosis were evaluated. Dietary intake was quantified by the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Intake of antioxidants was expressed in relation to total caloric intake.

RESULTS: Neither absolute, recommended daily allowance or weight-related values of nutritional intake variables were associated with cIMT. Vitamin E to total calories intake (odds ratio, OR=0.08, 95%CI=0.03-0.89) was inversely associated with impaired FMD. Non-nutritional correlates of FMD <10% were: age (OR=1.02, 95%CI=1.0-1.05) and waist circumference (OR=1.03, 95%CI=1.0-1.06), and those of cIMT >0.8 mm were age (OR=1.10, 95%CI=1.05-1.15), pack-years (OR=1.02, 95%CI=1.0-1.04), C-reactive protein (OR=1.17, 95%CI=1.04-1.33) and total cholesterol (OR=1.01, 95%CI=1.0-1.02). Conclusions Differences in the factors correlating with cIMT >0.8 mm and FMD <10% might have implications for cardiovascular risk reduction. A lower antioxidant to caloric intake ratio might be a risk factor for impaired FMD.

Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalCurrent Vascular Pharmacology
Volume15
Issue number5
Publication statusPublished - Feb 1 2017

Keywords

  • Journal Article

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    Minotti, G. C., Cortese, F., Corsonello, A., Guadalupi, G., D Arcangelo, A. P., Palumbo, S. D., Naio, R., Clemente, O. D., Aurelio, A., Carone, S., Gelsumino, T., Gemignani, V., Bianchini, E., Vigotti, M., Faita, F., Greco, L., Primerano, R., Incalzi, R. A., & Ciccone, M. M. (2017). The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males: an observational study of 615 subjects. Current Vascular Pharmacology, 15(5), 482-490.