The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males: an observational study of 615 subjects

Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone

Research output: Contribution to journalArticle

Abstract

BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis.

DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery.

METHODS: 615 males (mean age ± SD: 40.8±9.8 years) without overt atherosclerosis were evaluated. Dietary intake was quantified by the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Intake of antioxidants was expressed in relation to total caloric intake.

RESULTS: Neither absolute, recommended daily allowance or weight-related values of nutritional intake variables were associated with cIMT. Vitamin E to total calories intake (odds ratio, OR=0.08, 95%CI=0.03-0.89) was inversely associated with impaired FMD. Non-nutritional correlates of FMD <10% were: age (OR=1.02, 95%CI=1.0-1.05) and waist circumference (OR=1.03, 95%CI=1.0-1.06), and those of cIMT >0.8 mm were age (OR=1.10, 95%CI=1.05-1.15), pack-years (OR=1.02, 95%CI=1.0-1.04), C-reactive protein (OR=1.17, 95%CI=1.04-1.33) and total cholesterol (OR=1.01, 95%CI=1.0-1.02). Conclusions Differences in the factors correlating with cIMT >0.8 mm and FMD <10% might have implications for cardiovascular risk reduction. A lower antioxidant to caloric intake ratio might be a risk factor for impaired FMD.

Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalCurrent Vascular Pharmacology
Volume15
Issue number5
Publication statusPublished - Feb 1 2017

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Carotid Intima-Media Thickness
Observational Studies
Dilatation
Young Adult
Atherosclerosis
Energy Intake
Antioxidants
Recommended Dietary Allowances
Brachial Artery
Nutritive Value
Waist Circumference
Risk Reduction Behavior
Vitamin E
Vegetables
C-Reactive Protein
Fruit
Cross-Sectional Studies
Odds Ratio
Cholesterol
Weights and Measures

Keywords

  • Journal Article

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The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males : an observational study of 615 subjects. / Minotti, Girolamo Catapano; Cortese, Francesca; Corsonello, Andrea; Guadalupi, Giovanni; D Arcangelo, Antonio Paolo; Palumbo, Saverio Daniele; Naio, Rita; Clemente, Ottovio De; Aurelio, Andrea; Carone, Simona; Gelsumino, Tiziana; Gemignani, Vincenzo; Bianchini, Elisabetta; Vigotti, Mariangela; Faita, Francesco; Greco, Luciano; Primerano, Roberto; Incalzi, Raffaele Antonelli; Ciccone, Marco Matteo.

In: Current Vascular Pharmacology, Vol. 15, No. 5, 01.02.2017, p. 482-490.

Research output: Contribution to journalArticle

Minotti, GC, Cortese, F, Corsonello, A, Guadalupi, G, D Arcangelo, AP, Palumbo, SD, Naio, R, Clemente, OD, Aurelio, A, Carone, S, Gelsumino, T, Gemignani, V, Bianchini, E, Vigotti, M, Faita, F, Greco, L, Primerano, R, Incalzi, RA & Ciccone, MM 2017, 'The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males: an observational study of 615 subjects', Current Vascular Pharmacology, vol. 15, no. 5, pp. 482-490.
Minotti, Girolamo Catapano ; Cortese, Francesca ; Corsonello, Andrea ; Guadalupi, Giovanni ; D Arcangelo, Antonio Paolo ; Palumbo, Saverio Daniele ; Naio, Rita ; Clemente, Ottovio De ; Aurelio, Andrea ; Carone, Simona ; Gelsumino, Tiziana ; Gemignani, Vincenzo ; Bianchini, Elisabetta ; Vigotti, Mariangela ; Faita, Francesco ; Greco, Luciano ; Primerano, Roberto ; Incalzi, Raffaele Antonelli ; Ciccone, Marco Matteo. / The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males : an observational study of 615 subjects. In: Current Vascular Pharmacology. 2017 ; Vol. 15, No. 5. pp. 482-490.
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T1 - The influence of dietary components on early signs of atherosclerosis in apparently healthy young-adult males

T2 - an observational study of 615 subjects

AU - Minotti, Girolamo Catapano

AU - Cortese, Francesca

AU - Corsonello, Andrea

AU - Guadalupi, Giovanni

AU - D Arcangelo, Antonio Paolo

AU - Palumbo, Saverio Daniele

AU - Naio, Rita

AU - Clemente, Ottovio De

AU - Aurelio, Andrea

AU - Carone, Simona

AU - Gelsumino, Tiziana

AU - Gemignani, Vincenzo

AU - Bianchini, Elisabetta

AU - Vigotti, Mariangela

AU - Faita, Francesco

AU - Greco, Luciano

AU - Primerano, Roberto

AU - Incalzi, Raffaele Antonelli

AU - Ciccone, Marco Matteo

PY - 2017/2/1

Y1 - 2017/2/1

N2 - BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis.DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery.METHODS: 615 males (mean age ± SD: 40.8±9.8 years) without overt atherosclerosis were evaluated. Dietary intake was quantified by the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Intake of antioxidants was expressed in relation to total caloric intake.RESULTS: Neither absolute, recommended daily allowance or weight-related values of nutritional intake variables were associated with cIMT. Vitamin E to total calories intake (odds ratio, OR=0.08, 95%CI=0.03-0.89) was inversely associated with impaired FMD. Non-nutritional correlates of FMD <10% were: age (OR=1.02, 95%CI=1.0-1.05) and waist circumference (OR=1.03, 95%CI=1.0-1.06), and those of cIMT >0.8 mm were age (OR=1.10, 95%CI=1.05-1.15), pack-years (OR=1.02, 95%CI=1.0-1.04), C-reactive protein (OR=1.17, 95%CI=1.04-1.33) and total cholesterol (OR=1.01, 95%CI=1.0-1.02). Conclusions Differences in the factors correlating with cIMT >0.8 mm and FMD <10% might have implications for cardiovascular risk reduction. A lower antioxidant to caloric intake ratio might be a risk factor for impaired FMD.

AB - BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis.DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery.METHODS: 615 males (mean age ± SD: 40.8±9.8 years) without overt atherosclerosis were evaluated. Dietary intake was quantified by the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. Intake of antioxidants was expressed in relation to total caloric intake.RESULTS: Neither absolute, recommended daily allowance or weight-related values of nutritional intake variables were associated with cIMT. Vitamin E to total calories intake (odds ratio, OR=0.08, 95%CI=0.03-0.89) was inversely associated with impaired FMD. Non-nutritional correlates of FMD <10% were: age (OR=1.02, 95%CI=1.0-1.05) and waist circumference (OR=1.03, 95%CI=1.0-1.06), and those of cIMT >0.8 mm were age (OR=1.10, 95%CI=1.05-1.15), pack-years (OR=1.02, 95%CI=1.0-1.04), C-reactive protein (OR=1.17, 95%CI=1.04-1.33) and total cholesterol (OR=1.01, 95%CI=1.0-1.02). Conclusions Differences in the factors correlating with cIMT >0.8 mm and FMD <10% might have implications for cardiovascular risk reduction. A lower antioxidant to caloric intake ratio might be a risk factor for impaired FMD.

KW - Journal Article

M3 - Article

C2 - 28155612

VL - 15

SP - 482

EP - 490

JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

SN - 1570-1611

IS - 5

ER -