The influence of disease and comorbidity risk assessments on the survival of MDS and oligoblastic AML patients treated with 5-azacitidine: A retrospective analysis in ten centers of the "Rete Ematologica Lombarda"

Alfredo Molteni, Marta Riva, L. Borin, Massimo Bernardi, Anna Maria Pelizzari, Alessandra Freyrie, Matteo Giovanni Della Porta, Michele Nichelatti, Emanuele Ravano, Giulia Quaresmini, Jacopo Mariotti, Domenica Caramazza, Marta Ubezio, Simona Guarco, Federica Gigli, Rosa Greco, Roberto Cairoli, Enrica Morra

Research output: Contribution to journalArticle

Abstract

5-Azacytidine is an effective therapy in high risk MDS and oligoblastic AML. This "real life" analysis was made on 185 patients treated with 5-azacytidine in 10 centers afferent to REL ("Rete Ematologica Lombarda"), a network in Lombardia region. The aim was to assess the influence of disease and comorbidity risk assessments on the survival. The results confirm the utility of 5-azacitidine in prolonging OS regardless of advanced age and the presence of comorbidities. They also encourage an early treatment since patients with IPSS-R High risk MDS have better outcome with respect to Very High risk ones. According to the IPSS cytogenetic risk, there was no difference in the outcome between Intermediate and High risk patients. Nevertheless, a poorer cytogenetic risk, according to the IPSS-R cytogenetic stratification, negatively influenced the outcome.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalLeukemia Research
Volume42
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • 5-Azacytidine
  • High risk myelodysplastic syndromes
  • Oligoblastic acute myeloid leukemia
  • Prognostic indices

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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