The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs

Benilde Cosmi, Cristina Legnani, Vittorio Pengo, Angelo Ghirarduzzi, Sophie Testa, Daniela Poli, Domenico Prisco, Armando Tripodi, Gualtiero Palareti

Research output: Contribution to journalArticle

Abstract

It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptomatic pulmonary embolism (PE). Patients were enrolled in two prospective multicentre studies: PROLONG and PROLONG II. RVO was detected by compression ultrasonography according to the method of Prandoni on the day of anticoagulation withdrawal. Patients were also screened for FVL and FII mutation. The presence of FVL and/or FII mutation was determined in 872/963 (90.5%) patients, in 753 of whom RVO was assessed. FVL was significantly less frequent among subjects with isolated PE (7/176:4%) than among patients with either DVT and PE (15/133:11.3%; p=0.0018) or isolated DVT (89/563:15.8%; p

Original languageEnglish
Pages (from-to)510-516
Number of pages7
JournalThrombosis and Haemostasis
Volume109
Issue number3
DOIs
Publication statusPublished - Jan 10 2013

Keywords

  • Deep-vein thrombosis
  • Pulmonary embolism
  • Residual vein obstruction
  • Thrombophilia
  • Venous thrombosis

ASJC Scopus subject areas

  • Hematology

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