The influence of Helicobacter pylori eradication on the gastric mucosal content of epidermal growth factor, transforming growth factor-α, and their common receptor

F. Russo, C. Messa, L. Amati, L. Caradonna, C. Leoci, G. Di Matteo, E. Jirillo, A. Di Leo

Research output: Contribution to journalArticle

Abstract

Background: The relationship between the expression of epidermal growth factor (EGF) and transforming growth factor-α (TGF-α) and that of their receptor (EGF-R) in the Helicobacter pylori-infected gastric mucosa has not been completely elucidated. The aim of this study was to examine the interplay between H. pylori colonization and gastric mucosal growth factor content. Methods: By means of a solid-phase enzyme-linked immunosorbent assay EGF, TGF-α, and EGF-R levels and interleukin-1β (IL-1β) content, which is considered a marker of chronic inflammation, were evaluated in the antral mucosa of 24 H. pylori-positive patients before and 8 weeks after eradication therapy Results: After therapy H. pylori was eradicated in 19 patients. The eradication was accompanied by a significant decrease in IL-1β content and an increase in EGF and TGF-α levels. On the other hand, in the five patients in whom the bacterium was not eradicated EGF, TGF-α, and EGF-R levers were quite similar to those assayed before therapy, whereas IL-1β content was still high. Conclusions: These results suggest that H. pylori exerts an inhibitory effect on the mucosal expression of EGF and TGF-α, which are likely involved in the gastric mucosa repair process.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume33
Issue number3
DOIs
Publication statusPublished - 1998

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Gastrointestinal Contents
Transforming Growth Factors
Epidermal Growth Factor
Helicobacter pylori
Interleukin-1
Gastric Mucosa
Growth Factor Receptors
Intercellular Signaling Peptides and Proteins
Stomach
Mucous Membrane
Therapeutics
Enzyme-Linked Immunosorbent Assay
Inflammation
Bacteria

Keywords

  • Cytokines
  • Epidermal growth factor
  • Epidermal growth factor receptor
  • Growth factors
  • Helicobacter pylori
  • Peptic ulcer disease
  • Transforming growth factor alpha

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The influence of Helicobacter pylori eradication on the gastric mucosal content of epidermal growth factor, transforming growth factor-α, and their common receptor. / Russo, F.; Messa, C.; Amati, L.; Caradonna, L.; Leoci, C.; Di Matteo, G.; Jirillo, E.; Di Leo, A.

In: Scandinavian Journal of Gastroenterology, Vol. 33, No. 3, 1998, p. 271-275.

Research output: Contribution to journalArticle

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AU - Caradonna, L.

AU - Leoci, C.

AU - Di Matteo, G.

AU - Jirillo, E.

AU - Di Leo, A.

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