Background: The relationship between the expression of epidermal growth factor (EGF) and transforming growth factor-α (TGF-α) and that of their receptor (EGF-R) in the Helicobacter pylori-infected gastric mucosa has not been completely elucidated. The aim of this study was to examine the interplay between H. pylori colonization and gastric mucosal growth factor content. Methods: By means of a solid-phase enzyme-linked immunosorbent assay EGF, TGF-α, and EGF-R levels and interleukin-1β (IL-1β) content, which is considered a marker of chronic inflammation, were evaluated in the antral mucosa of 24 H. pylori-positive patients before and 8 weeks after eradication therapy Results: After therapy H. pylori was eradicated in 19 patients. The eradication was accompanied by a significant decrease in IL-1β content and an increase in EGF and TGF-α levels. On the other hand, in the five patients in whom the bacterium was not eradicated EGF, TGF-α, and EGF-R levers were quite similar to those assayed before therapy, whereas IL-1β content was still high. Conclusions: These results suggest that H. pylori exerts an inhibitory effect on the mucosal expression of EGF and TGF-α, which are likely involved in the gastric mucosa repair process.
- Epidermal growth factor
- Epidermal growth factor receptor
- Growth factors
- Helicobacter pylori
- Peptic ulcer disease
- Transforming growth factor alpha
ASJC Scopus subject areas