TY - JOUR
T1 - The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer
AU - Vantsant, Hans Pieter
AU - Kamman, Arnoud
AU - Hop, Wim C J
AU - Van Der Heijden, Martijn
AU - Lange, Johan F.
AU - Contant, Caroline M E
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer. Methods Long-term outcome of patients of 2 main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed. Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality. Results A total of 382 patients underwent potentially curative surgery for colorectal cancer. One hundred seventy-seven (46%) patients were treated with MBP and 205 (54%) were not before surgery. Median follow-up was 7.6 years (mean 6.6, range.01 to 12.73). There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP (P =.76 and P =.36, respectively). Multivariate analysis, taking account of age, sex, AJCC cancer stage, and ASA classification, also showed no survival difference. Conclusions Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer.
AB - Background In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer. Methods Long-term outcome of patients of 2 main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed. Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality. Results A total of 382 patients underwent potentially curative surgery for colorectal cancer. One hundred seventy-seven (46%) patients were treated with MBP and 205 (54%) were not before surgery. Median follow-up was 7.6 years (mean 6.6, range.01 to 12.73). There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP (P =.76 and P =.36, respectively). Multivariate analysis, taking account of age, sex, AJCC cancer stage, and ASA classification, also showed no survival difference. Conclusions Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer.
KW - Colorectal cancer
KW - Surgery
KW - Survival
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U2 - 10.1016/j.amjsurg.2014.10.022
DO - 10.1016/j.amjsurg.2014.10.022
M3 - Article
AN - SCOPUS:84931574356
VL - 210
SP - 106
EP - 110
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 1
ER -