The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer

Hans Pieter Vantsant, Arnoud Kamman, Wim C J Hop, Martijn Van Der Heijden, Johan F. Lange, Caroline M E Contant

Research output: Contribution to journalArticle

Abstract

Background In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer. Methods Long-term outcome of patients of 2 main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed. Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality. Results A total of 382 patients underwent potentially curative surgery for colorectal cancer. One hundred seventy-seven (46%) patients were treated with MBP and 205 (54%) were not before surgery. Median follow-up was 7.6 years (mean 6.6, range.01 to 12.73). There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP (P =.76 and P =.36, respectively). Multivariate analysis, taking account of age, sex, AJCC cancer stage, and ASA classification, also showed no survival difference. Conclusions Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer.

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalAmerican Journal of Surgery
Volume210
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Colorectal cancer
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Surgery

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    Vantsant, H. P., Kamman, A., Hop, W. C. J., Van Der Heijden, M., Lange, J. F., & Contant, C. M. E. (2015). The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer. American Journal of Surgery, 210(1), 106-110. https://doi.org/10.1016/j.amjsurg.2014.10.022