The influence of parity on multinodular goiter prevalence in areas with moderate iodine deficiency

M. Rotondi, F. Sorvillo, G. Mazziotti, S. Balzano, S. Iorio, A. Savoia, M. Piscopo, B. Biondi, G. Amato, Carlo Carella

Research output: Contribution to journalArticle

Abstract

Despite the observation that parity may increase the risk of thyroid carcinoma, very few studies have investigated the possible repercussion of parity on thyroid benign pathology. Recently, parity has been identified as one of the factors contributing to a larger thyroid size in healthy females. The aim of this work was to investigate a possible role for parity on the prevalence of multinodular goiter in iodine deficient areas. For this purpose, the reproductive histories of 2 cohorts of women, normal (Group I, 235 cases) and non-toxic multinodular goiter (NTMNG) affected (Group II, 274 cases) were compared. All subjects were euthyroid and had no previous history of thyroid function abnormalities. The number of full-term previous pregnancies (2.55±0.11 vs 1.77±0.10) and age (47.7±0.76 vs 42.3±0.83 yr) were found significantly higher (p

Original languageEnglish
Pages (from-to)442-446
Number of pages5
JournalJournal of Endocrinological Investigation
Volume25
Issue number5
Publication statusPublished - 2002

Keywords

  • Iodine deficiency
  • Multinodular goiter
  • Parity
  • Pregnancy

ASJC Scopus subject areas

  • Endocrinology

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    Rotondi, M., Sorvillo, F., Mazziotti, G., Balzano, S., Iorio, S., Savoia, A., Piscopo, M., Biondi, B., Amato, G., & Carella, C. (2002). The influence of parity on multinodular goiter prevalence in areas with moderate iodine deficiency. Journal of Endocrinological Investigation, 25(5), 442-446.