Abstract
Metabolic syndrome includes most widely distributed clinical conditions such as obesity, hypertension, dislipidemia, and diabetes. Pomegranate fruit extract (PFE), rich in polyphenolic antioxidants, reduces the expression of oxidation-sensitive genes at the sites of perturbed shear-stress. The aim of this study was to evaluate the effect of PFE in comparison to regular pomegranate juice (PJ) and seed oil on the biological actions of nitric oxide (NO) and the arterial function in obese Zucker rats, a model of metabolic syndrome. Our results indicated that supplementation with PFE or PJ significantly decreased the expression of vascular inflammation markers, thrombospondin (TSP), and cytokine TGFβ1 (P <0.05), whereas seed oil supplementation had a significant effect only on TSP-1 expression (P <0.05). Plasma nitrate and nitrite (NOx) levels were significantly increased by PFE and PJ (P <0.05). Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Nitric Oxide - Biology and Chemistry |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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Keywords
- Arterial function
- Metabolic syndrome
- Nitric oxide
- Pomegranate
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
Cite this
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. / de Nigris, Filomena; Balestrieri, Maria Luisa; Williams-Ignarro, Sharon; D'Armiento, Francesco P.; Fiorito, Carmela; Ignarro, Louis J.; Napoli, Claudio.
In: Nitric Oxide - Biology and Chemistry, Vol. 17, No. 1, 08.2007, p. 50-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats
AU - de Nigris, Filomena
AU - Balestrieri, Maria Luisa
AU - Williams-Ignarro, Sharon
AU - D'Armiento, Francesco P.
AU - Fiorito, Carmela
AU - Ignarro, Louis J.
AU - Napoli, Claudio
PY - 2007/8
Y1 - 2007/8
N2 - Metabolic syndrome includes most widely distributed clinical conditions such as obesity, hypertension, dislipidemia, and diabetes. Pomegranate fruit extract (PFE), rich in polyphenolic antioxidants, reduces the expression of oxidation-sensitive genes at the sites of perturbed shear-stress. The aim of this study was to evaluate the effect of PFE in comparison to regular pomegranate juice (PJ) and seed oil on the biological actions of nitric oxide (NO) and the arterial function in obese Zucker rats, a model of metabolic syndrome. Our results indicated that supplementation with PFE or PJ significantly decreased the expression of vascular inflammation markers, thrombospondin (TSP), and cytokine TGFβ1 (P <0.05), whereas seed oil supplementation had a significant effect only on TSP-1 expression (P <0.05). Plasma nitrate and nitrite (NOx) levels were significantly increased by PFE and PJ (P <0.05). Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome.
AB - Metabolic syndrome includes most widely distributed clinical conditions such as obesity, hypertension, dislipidemia, and diabetes. Pomegranate fruit extract (PFE), rich in polyphenolic antioxidants, reduces the expression of oxidation-sensitive genes at the sites of perturbed shear-stress. The aim of this study was to evaluate the effect of PFE in comparison to regular pomegranate juice (PJ) and seed oil on the biological actions of nitric oxide (NO) and the arterial function in obese Zucker rats, a model of metabolic syndrome. Our results indicated that supplementation with PFE or PJ significantly decreased the expression of vascular inflammation markers, thrombospondin (TSP), and cytokine TGFβ1 (P <0.05), whereas seed oil supplementation had a significant effect only on TSP-1 expression (P <0.05). Plasma nitrate and nitrite (NOx) levels were significantly increased by PFE and PJ (P <0.05). Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome.
KW - Arterial function
KW - Metabolic syndrome
KW - Nitric oxide
KW - Pomegranate
UR - http://www.scopus.com/inward/record.url?scp=34447498775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447498775&partnerID=8YFLogxK
U2 - 10.1016/j.niox.2007.04.005
DO - 10.1016/j.niox.2007.04.005
M3 - Article
C2 - 17553710
AN - SCOPUS:34447498775
VL - 17
SP - 50
EP - 54
JO - Nitric Oxide - Biology and Chemistry
JF - Nitric Oxide - Biology and Chemistry
SN - 1089-8603
IS - 1
ER -