TY - JOUR
T1 - The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients
T2 - results from the IN2 study
AU - Consoli, Domenico
AU - Vidale, Simone
AU - Aguglia, Umberto
AU - Bassi, Pietro
AU - Cavallini, Anna
AU - Consoli, Arturo
AU - Galati, Franco
AU - Guidetti, Donata
AU - Micieli, Giuseppe
AU - Neri, Giuseppe
AU - Rasura, Maurizia
AU - Sterzi, Roberto
AU - Toni, Danilo
AU - Inzitari, Domenico
PY - 2015/3/26
Y1 - 2015/3/26
N2 - Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56 %) patients were enrolled in this prospective case–control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1 %) and 207 (23.6 %) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95 % CI 1.02–1.09; p
AB - Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56 %) patients were enrolled in this prospective case–control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1 %) and 207 (23.6 %) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95 % CI 1.02–1.09; p
KW - Chlamydia pneumoniae
KW - Infections
KW - Ischemic stroke
KW - Outcome
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U2 - 10.1007/s00415-015-7712-9
DO - 10.1007/s00415-015-7712-9
M3 - Article
C2 - 25808504
AN - SCOPUS:84929834714
VL - 262
SP - 1310
EP - 1316
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 5
ER -