The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study

Domenico Consoli, Simone Vidale, Umberto Aguglia, Pietro Bassi, Anna Cavallini, Arturo Consoli, Franco Galati, Donata Guidetti, Giuseppe Micieli, Giuseppe Neri, Maurizia Rasura, Roberto Sterzi, Danilo Toni, Domenico Inzitari

Research output: Contribution to journalArticlepeer-review

Abstract

Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56 %) patients were enrolled in this prospective case–control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1 %) and 207 (23.6 %) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95 % CI 1.02–1.09; p 

Original languageEnglish
Pages (from-to)1310-1316
Number of pages7
JournalJournal of Neurology
Volume262
Issue number5
DOIs
Publication statusPublished - Mar 26 2015

Keywords

  • Chlamydia pneumoniae
  • Infections
  • Ischemic stroke
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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