The influence of prostatic volume and histological inflammation on the percentage of free serum prostate-specific antigens in men undergoing open prostatectomy for benign prostatic hyperplasia

V. Scattoni, M. Raber, L. Bua, M. Roscigno, P. Tognoni, G. Calori, M. Freschi, R. Daverio, P. Rigatti

Research output: Contribution to journalArticle

Abstract

The exact cause of the PSA rise in benign prostatic hyperplasia (BPH) is still subject to debate. We investigated whether preoperative and postoperative Free (F)-PSA, Total (T)-PSA levels and the free-to-total PSA ratio were correlated with the weight and histological prostatitis of specimens removed from men during open prostatectomy for BPH. Forty-four patients with BPH (normal digital rectal examination and transrectal ultrasound plus negative biopsies) undergoing open prostatectomy for bladder outlet obstruction were prospectively evaluated. Each prostatectomy specimen was weighed before histological analysis. Each slide was evaluated, without knowledge of the serum PSA levels, for inflammation which was divided into three main categories: acute prostatitis, chronic-active prostatitis and chronic-inactive prostatitis. Histological prostatitis was expressed in three grades: none-to-minimal, moderate, and severe. The mean preoperative T-PSA and F-PSA levels were 6.1 4.3 (SD) ng/ml (Prostatus TM Free/Total assay, Delfia Reagents: Wallac Oy, Turku, Finland) and 1.7 1.6 ng/ml. T-PSA was abnormal (> 4.0 ng/ml) in 24 patients (55%). F/T PSA ratio was >= 18 in 27 patients (61%). The mean prostatic and adenoma volume was 83.9 28.4 and 55.4 27.6 cc respectively. The mean postoperative T-PSA and F-PSA levels were 1.14 0.88 ng/ml and 0.23 0.18 ng/ml respectively. Both T-PSA and F-PSA levels were correlated with total gland volume (p=0.0001; p=0.002) and the volume of the surgical specimen (p=0.003; p 18 (p=0.03) while 55% of patients with chronic-inactive prostatitis had a ratio <18 (p

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalActa Urologica Italica
Volume13
Issue number1
Publication statusPublished - 1999

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Prostatitis
Prostatic Hyperplasia
Prostate-Specific Antigen
Prostatectomy
Inflammation
Serum
Urinary Bladder Neck Obstruction
Digital Rectal Examination
Finland
Biopsy
Weights and Measures

Keywords

  • Alpha-1- antichymotrypsin
  • Benign prostatic hyperplasia
  • Prostate-specific antigen
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

The influence of prostatic volume and histological inflammation on the percentage of free serum prostate-specific antigens in men undergoing open prostatectomy for benign prostatic hyperplasia. / Scattoni, V.; Raber, M.; Bua, L.; Roscigno, M.; Tognoni, P.; Calori, G.; Freschi, M.; Daverio, R.; Rigatti, P.

In: Acta Urologica Italica, Vol. 13, No. 1, 1999, p. 9-13.

Research output: Contribution to journalArticle

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abstract = "The exact cause of the PSA rise in benign prostatic hyperplasia (BPH) is still subject to debate. We investigated whether preoperative and postoperative Free (F)-PSA, Total (T)-PSA levels and the free-to-total PSA ratio were correlated with the weight and histological prostatitis of specimens removed from men during open prostatectomy for BPH. Forty-four patients with BPH (normal digital rectal examination and transrectal ultrasound plus negative biopsies) undergoing open prostatectomy for bladder outlet obstruction were prospectively evaluated. Each prostatectomy specimen was weighed before histological analysis. Each slide was evaluated, without knowledge of the serum PSA levels, for inflammation which was divided into three main categories: acute prostatitis, chronic-active prostatitis and chronic-inactive prostatitis. Histological prostatitis was expressed in three grades: none-to-minimal, moderate, and severe. The mean preoperative T-PSA and F-PSA levels were 6.1 4.3 (SD) ng/ml (Prostatus TM Free/Total assay, Delfia Reagents: Wallac Oy, Turku, Finland) and 1.7 1.6 ng/ml. T-PSA was abnormal (> 4.0 ng/ml) in 24 patients (55{\%}). F/T PSA ratio was >= 18 in 27 patients (61{\%}). The mean prostatic and adenoma volume was 83.9 28.4 and 55.4 27.6 cc respectively. The mean postoperative T-PSA and F-PSA levels were 1.14 0.88 ng/ml and 0.23 0.18 ng/ml respectively. Both T-PSA and F-PSA levels were correlated with total gland volume (p=0.0001; p=0.002) and the volume of the surgical specimen (p=0.003; p 18 (p=0.03) while 55{\%} of patients with chronic-inactive prostatitis had a ratio <18 (p",
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AU - Freschi, M.

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