Three different routes for ricin administration were tested in pools of rats bearing tumor in the subrenal capsule. Ricin uptake according to different routes shows a gradual increase in vital tumor from i.v. through i.a.b., c.i.a and perfusion. As far as the spleen and liver are concerned, a steep decrease from i.v. and i.a.b. to c.i.a. and perfusion was observed. Specific uptake of ricin (ricin/albumin ratio) by tumor, kidneys, spleen and liver seems to be related to the selectivity of the route. This was also observed for ricin extraction (organ/blood and organ/perfusate ratios) by tumor and different organs. In perfusion the systemic leakage of ricin is quite low and relatively constant. These results show that perfusion is the most effective route for achieving high ricin concentrations at the tumor site and low concentrations at aspecific target organs (liver and spleen).
|Number of pages||7|
|Journal||Journal of Experimental and Clinical Cancer Research|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Cancer Research