The influence of route of administration on ricin distribution in an experimental tumor-bearing rat model

C. R. Rossi, M. Foletto, S. Irsara, G. Segato, T. Martello, A. Seno, G. Mancino, M. Lise

Research output: Contribution to journalArticlepeer-review

Abstract

Three different routes for ricin administration were tested in pools of rats bearing tumor in the subrenal capsule. Ricin uptake according to different routes shows a gradual increase in vital tumor from i.v. through i.a.b., c.i.a and perfusion. As far as the spleen and liver are concerned, a steep decrease from i.v. and i.a.b. to c.i.a. and perfusion was observed. Specific uptake of ricin (ricin/albumin ratio) by tumor, kidneys, spleen and liver seems to be related to the selectivity of the route. This was also observed for ricin extraction (organ/blood and organ/perfusate ratios) by tumor and different organs. In perfusion the systemic leakage of ricin is quite low and relatively constant. These results show that perfusion is the most effective route for achieving high ricin concentrations at the tumor site and low concentrations at aspecific target organs (liver and spleen).

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Volume11
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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