The influence of skeletal muscle on systemic aging and lifespan

Fabio Demontis, Rosanna Piccirillo, Alfred L. Goldberg, Norbert Perrimon

Research output: Contribution to journalArticlepeer-review


Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.

Original languageEnglish
Pages (from-to)943-949
Number of pages7
JournalAging Cell
Issue number6
Publication statusPublished - Dec 2013


  • Exercise
  • Intertissue communication during aging
  • Myokine signaling
  • Skeletal muscle aging
  • Systemic aging

ASJC Scopus subject areas

  • Cell Biology
  • Ageing


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