Abstract
This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the some marked hardcopies. The mean TLL was 22,734 mm3 for axial and 22,003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P = 0.01), but the fluctuations around this overage difference between axial and sagittal scan TLL were significantly large (test for interaction, P <0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients.
| Original language | English |
|---|---|
| Pages (from-to) | 382-384 |
| Number of pages | 3 |
| Journal | Multiple Sclerosis Journal |
| Volume | 3 |
| Issue number | 6 |
| Publication status | Published - 1997 |
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Keywords
- Lesion load
- Magnetic resonance imaging
- Multiple sclerosis
- Reproducibility
ASJC Scopus subject areas
- Clinical Neurology
Cite this
The influence of slice orientation on brain MRI lesion load measurement in multiple sclerosis. / Rovaris, M.; Sormani, M. P.; Rocca, Ma; Comi, G.; Filippi, M.
In: Multiple Sclerosis Journal, Vol. 3, No. 6, 1997, p. 382-384.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The influence of slice orientation on brain MRI lesion load measurement in multiple sclerosis
AU - Rovaris, M.
AU - Sormani, M. P.
AU - Rocca, Ma
AU - Comi, G.
AU - Filippi, M.
PY - 1997
Y1 - 1997
N2 - This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the some marked hardcopies. The mean TLL was 22,734 mm3 for axial and 22,003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P = 0.01), but the fluctuations around this overage difference between axial and sagittal scan TLL were significantly large (test for interaction, P <0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients.
AB - This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the some marked hardcopies. The mean TLL was 22,734 mm3 for axial and 22,003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P = 0.01), but the fluctuations around this overage difference between axial and sagittal scan TLL were significantly large (test for interaction, P <0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients.
KW - Lesion load
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Reproducibility
UR - http://www.scopus.com/inward/record.url?scp=0031446446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031446446&partnerID=8YFLogxK
M3 - Article
VL - 3
SP - 382
EP - 384
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 6
ER -