The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects

Melania Manco, Alessandro Bertuzzi, Serenella Salinari, Antonino Scarfone, Menotti Calvani, Aldo V. Greco, Geltrude Mingrone

Research output: Contribution to journalArticle

Abstract

To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100 g oral butter load or a 100 ml water load. At 120 min after the oral load a hyperglycaemic clamp was performed over 180 min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305.6 (SE 124.1) v. 616.1 (SE 52.5) pmol/min; P<0.01) and to a lesser degree in the obese subjects (1975.0 (SE 44.1) v. 1417.5 (SE 56.0) pmol/min; P-2 (SE 0.11 × 10-2) v. 2.26 × 10-2 (SE 0.32 × 10-2) ml/min per kgFFM per (pmol/l); P

Original languageEnglish
Pages (from-to)895-903
Number of pages9
JournalBritish Journal of Nutrition
Volume92
Issue number6
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Insulin resistance
  • Insulin secretion
  • Non-esterified fatty acids
  • Obesity
  • Triacylglycerols

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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