The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects

Melania Manco, Alessandro Bertuzzi, Serenella Salinari, Antonino Scarfone, Menotti Calvani, Aldo V. Greco, Geltrude Mingrone

Research output: Contribution to journalArticle

Abstract

To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100 g oral butter load or a 100 ml water load. At 120 min after the oral load a hyperglycaemic clamp was performed over 180 min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305.6 (SE 124.1) v. 616.1 (SE 52.5) pmol/min; P<0.01) and to a lesser degree in the obese subjects (1975.0 (SE 44.1) v. 1417.5 (SE 56.0) pmol/min; P-2 (SE 0.11 × 10-2) v. 2.26 × 10-2 (SE 0.32 × 10-2) ml/min per kgFFM per (pmol/l); P

Original languageEnglish
Pages (from-to)895-903
Number of pages9
JournalBritish Journal of Nutrition
Volume92
Issue number6
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Butter
Insulin Resistance
Triglycerides
Fatty Acids
Eating
Insulin
Water
C-Peptide
Dietary Fats
Weights and Measures
Glucose

Keywords

  • Insulin resistance
  • Insulin secretion
  • Non-esterified fatty acids
  • Obesity
  • Triacylglycerols

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects. / Manco, Melania; Bertuzzi, Alessandro; Salinari, Serenella; Scarfone, Antonino; Calvani, Menotti; Greco, Aldo V.; Mingrone, Geltrude.

In: British Journal of Nutrition, Vol. 92, No. 6, 12.2004, p. 895-903.

Research output: Contribution to journalArticle

Manco, Melania ; Bertuzzi, Alessandro ; Salinari, Serenella ; Scarfone, Antonino ; Calvani, Menotti ; Greco, Aldo V. ; Mingrone, Geltrude. / The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects. In: British Journal of Nutrition. 2004 ; Vol. 92, No. 6. pp. 895-903.
@article{1e52707161124b75832460f67bf88661,
title = "The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects",
abstract = "To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100 g oral butter load or a 100 ml water load. At 120 min after the oral load a hyperglycaemic clamp was performed over 180 min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305.6 (SE 124.1) v. 616.1 (SE 52.5) pmol/min; P<0.01) and to a lesser degree in the obese subjects (1975.0 (SE 44.1) v. 1417.5 (SE 56.0) pmol/min; P-2 (SE 0.11 × 10-2) v. 2.26 × 10-2 (SE 0.32 × 10-2) ml/min per kgFFM per (pmol/l); P",
keywords = "Insulin resistance, Insulin secretion, Non-esterified fatty acids, Obesity, Triacylglycerols",
author = "Melania Manco and Alessandro Bertuzzi and Serenella Salinari and Antonino Scarfone and Menotti Calvani and Greco, {Aldo V.} and Geltrude Mingrone",
year = "2004",
month = "12",
doi = "10.1079/BJN20041268",
language = "English",
volume = "92",
pages = "895--903",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "6",

}

TY - JOUR

T1 - The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects

AU - Manco, Melania

AU - Bertuzzi, Alessandro

AU - Salinari, Serenella

AU - Scarfone, Antonino

AU - Calvani, Menotti

AU - Greco, Aldo V.

AU - Mingrone, Geltrude

PY - 2004/12

Y1 - 2004/12

N2 - To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100 g oral butter load or a 100 ml water load. At 120 min after the oral load a hyperglycaemic clamp was performed over 180 min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305.6 (SE 124.1) v. 616.1 (SE 52.5) pmol/min; P<0.01) and to a lesser degree in the obese subjects (1975.0 (SE 44.1) v. 1417.5 (SE 56.0) pmol/min; P-2 (SE 0.11 × 10-2) v. 2.26 × 10-2 (SE 0.32 × 10-2) ml/min per kgFFM per (pmol/l); P

AB - To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100 g oral butter load or a 100 ml water load. At 120 min after the oral load a hyperglycaemic clamp was performed over 180 min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305.6 (SE 124.1) v. 616.1 (SE 52.5) pmol/min; P<0.01) and to a lesser degree in the obese subjects (1975.0 (SE 44.1) v. 1417.5 (SE 56.0) pmol/min; P-2 (SE 0.11 × 10-2) v. 2.26 × 10-2 (SE 0.32 × 10-2) ml/min per kgFFM per (pmol/l); P

KW - Insulin resistance

KW - Insulin secretion

KW - Non-esterified fatty acids

KW - Obesity

KW - Triacylglycerols

UR - http://www.scopus.com/inward/record.url?scp=11144296921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144296921&partnerID=8YFLogxK

U2 - 10.1079/BJN20041268

DO - 10.1079/BJN20041268

M3 - Article

C2 - 15613251

AN - SCOPUS:11144296921

VL - 92

SP - 895

EP - 903

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 6

ER -