The INHANCE consortium: Toward a better understanding of the causes and mechanisms of head and neck cancer

D. M. Winn, Y. C. Lee, M. Hashibe, P. Boffetta, Antonio Agudo, Wolfgang Ahrens, Vladimir Bencko, Simone Benhamou, Stefania Boccia, Cristina Bosetti, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Xavier Castellsague, Chu Chen, David Conway, Maria Paula Curado, Gypsyamber D'Souza, Luigino Dal Maso, Alexander W. DaudtKim De Ruyck, Brenda Diergaarde, Jose Eluf-Neto, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Maura Gillison, Robert I. Haddad, Richard Hayes, Claire Healy, Rolando Herrero, Jonathan Hofmann, Ivana Holcátová, Rayjean Hung, Karl Kelsey, Kristina Kjaerheim, Sergio Koifman, Carlo La Vecchia, Martin Lacko, Pagona Lagiou, Philip Lazarus, Fabio Levi, Guojun Li, Jolanta Lissowska, Geoffrey Liu, Daniele Luce, Tatiana Macfarlane, Manoj Mahimkar, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Franco Merletti, Kirsten Moysich, Joshua Muscat, Andy Olshan, Michael Pawlita, Wilbert H M Peters, Heribert Ramroth, Laura Rozek, Péter Rudnai, Stimson Schantz, Steve Schwartz, Diego Serraino, Oxana Shangina, Lorenzo Simonato, Elaine Smith, Isabelle Stucker, Erich M. Sturgis, Neonila Szeszenia-Dabrowska, Peter Thomson, Thomas Vaughan, Marta Vilensky, Gregory Wolf, Victor Wünsch-Filho, Guopei Yu, David Zaridze, Witold Zatonski, Jose P. Zevallos, Zuo Feng Zhang, Tong Zhang Zheng, Ariana Znaor

Research output: Contribution to journalArticlepeer-review


The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalOral Diseases
Issue number6
Publication statusPublished - Sep 1 2015


  • Epidemiology
  • Head and neck cancer

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology


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