The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia

MG Vilia; E Fonte; T Veliz Rodriguez; M Tocchetti; P Ranghetti; L Scarfò; N Papakonstantinou; S Ntoufa; K Stamatopoulos; P Ghia; M Muzio

doi:10.1080/10428194.2017.1295142

The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia

MG Vilia, E Fonte, T Veliz Rodriguez, M Tocchetti, P Ranghetti, L Scarfò, N Papakonstantinou, S Ntoufa, K Stamatopoulos, P Ghia, M Muzio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Toll interleukin-1 receptor 8 (also known as TIR8, SIGIRR, or IL1R8) is a transmembrane receptor that inhibits inflammation. Accordingly, genetic inactivation of this protein exacerbates chronic inflammation and inflammation-associated tumors in mice. In particular, lack of TIR8 triggers leukemia progression in a mouse model of chronic lymphocytic leukemia (CLL), supporting its role as a novel tumor restrainer. The aim of this study was to measure the amount of TIR8 mRNA and protein in CLL cells, and to analyze its regulation of expression. Circulating leukemic cells expressed lower levels of TIR8 compared to normal B-lymphocytes. Treatment of CLL cells with Azacytidine restored higher levels of TIR8 suggesting that DNA methylation may be involved in modulating TIR8 expression, with implications for novel therapeutic strategies. © 2017 Informa UK Limited, trading as Taylor & Francis Group

Original language	English
Pages (from-to)	2419-2425
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	58
Issue number	10
DOIs	https://doi.org/10.1080/10428194.2017.1295142
Publication status	Published - 2017

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Vilia, MG., Fonte, E., Veliz Rodriguez, T., Tocchetti, M., Ranghetti, P., Scarfò, L., Papakonstantinou, N., Ntoufa, S., Stamatopoulos, K., Ghia, P., & Muzio, M. (2017). The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia. Leukemia and Lymphoma, 58(10), 2419-2425. https://doi.org/10.1080/10428194.2017.1295142

The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia. / Vilia, MG; Fonte, E; Veliz Rodriguez, T; Tocchetti, M; Ranghetti, P; Scarfò, L; Papakonstantinou, N; Ntoufa, S; Stamatopoulos, K; Ghia, P ; Muzio, M.

In: Leukemia and Lymphoma, Vol. 58, No. 10, 2017, p. 2419-2425.

Research output: Contribution to journal › Article

Vilia, MG, Fonte, E, Veliz Rodriguez, T, Tocchetti, M, Ranghetti, P, Scarfò, L, Papakonstantinou, N, Ntoufa, S, Stamatopoulos, K, Ghia, P & Muzio, M 2017, 'The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia', Leukemia and Lymphoma, vol. 58, no. 10, pp. 2419-2425. https://doi.org/10.1080/10428194.2017.1295142

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abstract = "Toll interleukin-1 receptor 8 (also known as TIR8, SIGIRR, or IL1R8) is a transmembrane receptor that inhibits inflammation. Accordingly, genetic inactivation of this protein exacerbates chronic inflammation and inflammation-associated tumors in mice. In particular, lack of TIR8 triggers leukemia progression in a mouse model of chronic lymphocytic leukemia (CLL), supporting its role as a novel tumor restrainer. The aim of this study was to measure the amount of TIR8 mRNA and protein in CLL cells, and to analyze its regulation of expression. Circulating leukemic cells expressed lower levels of TIR8 compared to normal B-lymphocytes. Treatment of CLL cells with Azacytidine restored higher levels of TIR8 suggesting that DNA methylation may be involved in modulating TIR8 expression, with implications for novel therapeutic strategies. {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group",

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AB - Toll interleukin-1 receptor 8 (also known as TIR8, SIGIRR, or IL1R8) is a transmembrane receptor that inhibits inflammation. Accordingly, genetic inactivation of this protein exacerbates chronic inflammation and inflammation-associated tumors in mice. In particular, lack of TIR8 triggers leukemia progression in a mouse model of chronic lymphocytic leukemia (CLL), supporting its role as a novel tumor restrainer. The aim of this study was to measure the amount of TIR8 mRNA and protein in CLL cells, and to analyze its regulation of expression. Circulating leukemic cells expressed lower levels of TIR8 compared to normal B-lymphocytes. Treatment of CLL cells with Azacytidine restored higher levels of TIR8 suggesting that DNA methylation may be involved in modulating TIR8 expression, with implications for novel therapeutic strategies. © 2017 Informa UK Limited, trading as Taylor & Francis Group

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