The interaction between alcohol, chlorpropamide and phenformin in a severe combined poisoning

case report.

L. Manzo, B. Allaria, P. Richelmi, G. Chiesa, A. de Gasperi, A. Crema

Research output: Contribution to journalArticle

Abstract

A young non-diabetic woman ingested 2.5-3.7 g of chlorpropamide and 0.6-0.9 g of phenformin together with a large dose of alcohol, nitrofurantoin and promethazine in a suicidal attempt. She developed severe metabolic acidosis, hypokalemia, polyuria and prolonged hypoglycemia in the absence of typical hypoglycemic symptoms. These unusual clinical features were in part explained on the basis of the interactions between alcohol and the other drugs.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalToxicological European research. Recherche europeenne en toxicologie
Volume1
Issue number4
Publication statusPublished - Jul 1978

Fingerprint

Phenformin
Chlorpropamide
Poisoning
Alcohols
Promethazine
Nitrofurantoin
Polyuria
Hypokalemia
Acidosis
Hypoglycemia
Hypoglycemic Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The interaction between alcohol, chlorpropamide and phenformin in a severe combined poisoning : case report. / Manzo, L.; Allaria, B.; Richelmi, P.; Chiesa, G.; de Gasperi, A.; Crema, A.

In: Toxicological European research. Recherche europeenne en toxicologie, Vol. 1, No. 4, 07.1978, p. 267-272.

Research output: Contribution to journalArticle

Manzo, L. ; Allaria, B. ; Richelmi, P. ; Chiesa, G. ; de Gasperi, A. ; Crema, A. / The interaction between alcohol, chlorpropamide and phenformin in a severe combined poisoning : case report. In: Toxicological European research. Recherche europeenne en toxicologie. 1978 ; Vol. 1, No. 4. pp. 267-272.
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