Abstract
Objective: The aim of this study was to determine the relationship between blood pressure (BP) variability and left ventricular (LV) mechanical function in untreated normal-weight, overweight, and obese hypertensive patients. Methods: This cross-sectional study included 144 untreated hypertensive study participants who underwent 24-h ambulatory BP monitoring and complete two (2DE) and three-dimensional echocardiography (3DE). All the patients were divided into three groups according to their BMI: normal-weight patients (BMI <25kg/m 2), overweight patients (25≤BMI <30kg/m 2), and obese patients (BMI≥30kg/m 2). Results: Daytime, night-time, and 24-h BP variability progressively increased from normal-weight, throughout overweight, to obese hypertensive study participants. 2DE and 3DE LV longitudinal, circumferential and radial strains, as well as 3DE area strain, were significantly lower in obese hypertensive patients than in normal-weight and overweight study participants. 3DE LV volumes indexed for BSA did not differ significantly among the three observed groups. Night-time and 24h BP variability indices, more than daytime BP variability parameters, were associated with 2DE and 3DE longitudinal and circumferential strains independent of BMI, LV mass index, and average 24-h SBP and DBP values. Conclusion: BP variability and LV deformation are significantly affected by obesity in untreated hypertensive patients. BP variability is associated with 2DE and 3DE LV mechanics independently of main clinical and echocardiographic characteristics.
| Original language | English |
|---|---|
| Pages (from-to) | 772-780 |
| Number of pages | 9 |
| Journal | Journal of Hypertension |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2016 |
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Keywords
- hypertension
- left ventricle
- obesity
- overweight
- three-dimensional echocardiography
- two-dimensional speckle tracking
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
The interaction between blood pressure variability, obesity, and left ventricular mechanics : Findings from the hypertensive population. / Tadic, Marijana; Cuspidi, Cesare; Pencic, Biljana; Andric, Anita; Pavlovic, Sinisa U.; Iracek, Olinka; Celic, Vera.
In: Journal of Hypertension, Vol. 34, No. 4, 01.04.2016, p. 772-780.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The interaction between blood pressure variability, obesity, and left ventricular mechanics
T2 - Findings from the hypertensive population
AU - Tadic, Marijana
AU - Cuspidi, Cesare
AU - Pencic, Biljana
AU - Andric, Anita
AU - Pavlovic, Sinisa U.
AU - Iracek, Olinka
AU - Celic, Vera
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objective: The aim of this study was to determine the relationship between blood pressure (BP) variability and left ventricular (LV) mechanical function in untreated normal-weight, overweight, and obese hypertensive patients. Methods: This cross-sectional study included 144 untreated hypertensive study participants who underwent 24-h ambulatory BP monitoring and complete two (2DE) and three-dimensional echocardiography (3DE). All the patients were divided into three groups according to their BMI: normal-weight patients (BMI <25kg/m 2), overweight patients (25≤BMI <30kg/m 2), and obese patients (BMI≥30kg/m 2). Results: Daytime, night-time, and 24-h BP variability progressively increased from normal-weight, throughout overweight, to obese hypertensive study participants. 2DE and 3DE LV longitudinal, circumferential and radial strains, as well as 3DE area strain, were significantly lower in obese hypertensive patients than in normal-weight and overweight study participants. 3DE LV volumes indexed for BSA did not differ significantly among the three observed groups. Night-time and 24h BP variability indices, more than daytime BP variability parameters, were associated with 2DE and 3DE longitudinal and circumferential strains independent of BMI, LV mass index, and average 24-h SBP and DBP values. Conclusion: BP variability and LV deformation are significantly affected by obesity in untreated hypertensive patients. BP variability is associated with 2DE and 3DE LV mechanics independently of main clinical and echocardiographic characteristics.
AB - Objective: The aim of this study was to determine the relationship between blood pressure (BP) variability and left ventricular (LV) mechanical function in untreated normal-weight, overweight, and obese hypertensive patients. Methods: This cross-sectional study included 144 untreated hypertensive study participants who underwent 24-h ambulatory BP monitoring and complete two (2DE) and three-dimensional echocardiography (3DE). All the patients were divided into three groups according to their BMI: normal-weight patients (BMI <25kg/m 2), overweight patients (25≤BMI <30kg/m 2), and obese patients (BMI≥30kg/m 2). Results: Daytime, night-time, and 24-h BP variability progressively increased from normal-weight, throughout overweight, to obese hypertensive study participants. 2DE and 3DE LV longitudinal, circumferential and radial strains, as well as 3DE area strain, were significantly lower in obese hypertensive patients than in normal-weight and overweight study participants. 3DE LV volumes indexed for BSA did not differ significantly among the three observed groups. Night-time and 24h BP variability indices, more than daytime BP variability parameters, were associated with 2DE and 3DE longitudinal and circumferential strains independent of BMI, LV mass index, and average 24-h SBP and DBP values. Conclusion: BP variability and LV deformation are significantly affected by obesity in untreated hypertensive patients. BP variability is associated with 2DE and 3DE LV mechanics independently of main clinical and echocardiographic characteristics.
KW - hypertension
KW - left ventricle
KW - obesity
KW - overweight
KW - three-dimensional echocardiography
KW - two-dimensional speckle tracking
UR - http://www.scopus.com/inward/record.url?scp=84960347822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960347822&partnerID=8YFLogxK
U2 - 10.1097/HJH.0000000000000830
DO - 10.1097/HJH.0000000000000830
M3 - Article
AN - SCOPUS:84960347822
VL - 34
SP - 772
EP - 780
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 4
ER -