To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.
- Tetrahydroisoquinoline derivatives
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