The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J. Vetulani; F. Pavone; B. Przewłocka; V. Borghi; I. Nalepa

doi:10.1007/s00702-003-0037-3

The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J. Vetulani, F. Pavone, B. Przewłocka, V. Borghi, I. Nalepa

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

Original language	English
Pages (from-to)	1205-1213
Number of pages	9
Journal	Journal of Neural Transmission
Volume	110
Issue number	11
DOIs	https://doi.org/10.1007/s00702-003-0037-3
Publication status	Published - Nov 2003

Keywords

Analgesia
Mice
Morphine
Oxotremorine
Tetrahydroisoquinoline derivatives

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1007/s00702-003-0037-3

Cite this

@article{e420b9b6aafe493f847991a79a2a2b15,

title = "The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice",

abstract = "To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.",

keywords = "Analgesia, Mice, Morphine, Oxotremorine, Tetrahydroisoquinoline derivatives",

author = "J. Vetulani and F. Pavone and B. Przew{\l}ocka and V. Borghi and I. Nalepa",

year = "2003",

month = nov,

doi = "10.1007/s00702-003-0037-3",

language = "English",

volume = "110",

pages = "1205--1213",

journal = "Journal of Neuro-Visceral Relations",

issn = "0375-9245",

publisher = "Springer-Verlag Wien",

number = "11",

}

TY - JOUR

T1 - The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

AU - Vetulani, J.

AU - Pavone, F.

AU - Przewłocka, B.

AU - Borghi, V.

AU - Nalepa, I.

PY - 2003/11

Y1 - 2003/11

N2 - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

AB - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

KW - Analgesia

KW - Mice

KW - Morphine

KW - Oxotremorine

KW - Tetrahydroisoquinoline derivatives

UR - http://www.scopus.com/inward/record.url?scp=0345490842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345490842&partnerID=8YFLogxK

U2 - 10.1007/s00702-003-0037-3

DO - 10.1007/s00702-003-0037-3

M3 - Article

C2 - 14628186

AN - SCOPUS:0345490842

VL - 110

SP - 1205

EP - 1213

JO - Journal of Neuro-Visceral Relations

JF - Journal of Neuro-Visceral Relations

SN - 0375-9245

IS - 11

ER -

The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this