TY - JOUR
T1 - The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice
AU - Vetulani, J.
AU - Pavone, F.
AU - Przewłocka, B.
AU - Borghi, V.
AU - Nalepa, I.
PY - 2003/11
Y1 - 2003/11
N2 - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.
AB - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.
KW - Analgesia
KW - Mice
KW - Morphine
KW - Oxotremorine
KW - Tetrahydroisoquinoline derivatives
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U2 - 10.1007/s00702-003-0037-3
DO - 10.1007/s00702-003-0037-3
M3 - Article
C2 - 14628186
AN - SCOPUS:0345490842
VL - 110
SP - 1205
EP - 1213
JO - Journal of Neuro-Visceral Relations
JF - Journal of Neuro-Visceral Relations
SN - 0375-9245
IS - 11
ER -