The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J. Vetulani, F. Pavone, B. Przewłocka, V. Borghi, I. Nalepa

Research output: Contribution to journalArticlepeer-review

Abstract

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

Original languageEnglish
Pages (from-to)1205-1213
Number of pages9
JournalJournal of Neural Transmission
Volume110
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Analgesia
  • Mice
  • Morphine
  • Oxotremorine
  • Tetrahydroisoquinoline derivatives

ASJC Scopus subject areas

  • Neuroscience(all)

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