The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J. Vetulani; F. Pavone; B. Przewłocka; V. Borghi; I. Nalepa

doi:10.1007/s00702-003-0037-3

The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

J. Vetulani, F. Pavone, B. Przewłocka, V. Borghi, I. Nalepa

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

Original language	English
Pages (from-to)	1205-1213
Number of pages	9
Journal	Journal of Neural Transmission
Volume	110
Issue number	11
DOIs	https://doi.org/10.1007/s00702-003-0037-3
Publication status	Published - Nov 2003

Keywords

Analgesia
Mice
Morphine
Oxotremorine
Tetrahydroisoquinoline derivatives

ASJC Scopus subject areas

Neuroscience(all)

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title = "The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice",

abstract = "To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.",

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AU - Vetulani, J.

AU - Pavone, F.

AU - Przewłocka, B.

AU - Borghi, V.

AU - Nalepa, I.

PY - 2003/11

Y1 - 2003/11

N2 - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

AB - To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3, 4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.

KW - Analgesia

KW - Mice

KW - Morphine

KW - Oxotremorine

KW - Tetrahydroisoquinoline derivatives

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The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

Abstract

Keywords

ASJC Scopus subject areas

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