The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma

P. Canedo, G. Corso, F. Pereira, N. Lunet, G. Suriano, C. Figueiredo, C. Pedrazzani, H. Moreira, H. Barros, F. Carneiro, R. Seruca, F. Roviello, J. C. Machado

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Abstract

Background and aim: It has been demonstrated that polymorphisms within inflammation-related genes are associated with the risk of gastric carcinoma (GC) in people infected with Helicobacter pylori. Recently, polymorphisms in the gene encoding the interferon gamma receptor 1 (IFNGR1) were found to be associated with increased susceptibility to H pylori infection. We aimed to determine the association between polymorphisms in the IFNGR1 gene and development of chronic gastritis and GC. Methods: In a case-control study including 733 controls, 213 patients with chronic gastritis and 393 patients with GC, the IFNGR1 -611*G/*A, -56*C/*T, +1004*A/*C and +1400*T/*C polymorphisms were genotyped. A second independent case-control study including 100 controls and 65 patients with GC was used for confirmation of the original results. The effect of the -56*C/*T promoter polymorphism in the level of expression of the IFNGR1 gene was evaluated by an IFNGR1 -56*C/*T allele specific luciferase reporter assay. Results: In patients with early onset GC (defined as being less than 40 years of age at the time of diagnosis) we found a significant over-representation of the IFNGR1 -56*T/*T homozygous genotype with an odds ratio (OR) of 4.1 (95% confidence interval (CI) 1.6 to 10.6). This result was confirmed in a second independent case-control study. In the luciferase reporter assay we observed a 10-fold increase (p

Original languageEnglish
Pages (from-to)1504-1508
Number of pages5
JournalGut
Volume57
Issue number11
DOIs
Publication statusPublished - Nov 2008

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Canedo, P., Corso, G., Pereira, F., Lunet, N., Suriano, G., Figueiredo, C., Pedrazzani, C., Moreira, H., Barros, H., Carneiro, F., Seruca, R., Roviello, F., & Machado, J. C. (2008). The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut, 57(11), 1504-1508. https://doi.org/10.1136/gut.2007.143578