Several studies have described polymorphisms in the genes encoding interleukin-1α (IL-1α) and IL-1β cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-β exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Biology
- Pathology and Forensic Medicine