The interleukin 1-β exonic (+3953) polymorphism does not alter in vitro protein secretion

Roberto Dominici, Giulia Malferrari, Claudio Mariani, Luigi M E Grimaldi, Ida Biunno

Research output: Contribution to journalArticle

Abstract

Several studies have described polymorphisms in the genes encoding interleukin-1α (IL-1α) and IL-1β cytokines and their implication in the onset of Alzheimer disease or in linkage disequilibrium with an as yet to be identified second locus on chromosome 2. However, these results have been associated with the sporadic forms of Alzheimer disease. Here we present data on the effects of the interleukin 1-β exonic polymorphism (+3953) using a series of cohort healthy control samples and in vitro protein secretion assays.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalExperimental and Molecular Pathology
Volume73
Issue number2
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

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