The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

Roberto Antonicelli, Fabiola Olivieri, Massimiliano Bonafè, Luca Cavallone, Liana Spazzafumo, Francesca Marchegiani, Maurizio Cardelli, Andrea Recanatini, Paolo Testarmata, Massimo Boemi, Gianfranco Parati, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Background: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (-174 G>C) and TNF-α(-308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients. Methods: We assessed the IL-6 -174 G>C polymorphism and TNF-α -308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up. Results: We found that IL-6 -174 G>C polymorphism is an independent predictor of cardiovascular death after an ACS in male patients. In particular ACS patients carrying the IL-6 -174 C- (GG) genotypes showed a marked increase in one year follow-up mortality rate (HR=3.89, 95% CI 1.71-8.86, p=0.001). Moreover CRP serum levels ≥5.5 mg/dl (HR= 3.79, 95% CI 1.71-8.42, p=0.001), a history of CHD (HR=2.96, 95% CI 1.22-7.20, p=0.016) and the absence of statins treatment (HR=3.27, 95% CI 1.17-9.18, p=0.021), significantly increased one year risk of death in male ACS patients. Conclusions: These data suggest that IL-6 -174 G>C polymorphism can be added to other clinical markers in order to identify a subgroup of elderly ACS male patients at higher risk of death.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalInternational Journal of Cardiology
Volume103
Issue number3
DOIs
Publication statusPublished - Sep 1 2005

Keywords

  • Acute coronary syndrome
  • IL-6 polymorphism
  • Inflammation
  • TNF-α polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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