The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

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Abstract

Background: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (-174 G>C) and TNF-α(-308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients. Methods: We assessed the IL-6 -174 G>C polymorphism and TNF-α -308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up. Results: We found that IL-6 -174 G>C polymorphism is an independent predictor of cardiovascular death after an ACS in male patients. In particular ACS patients carrying the IL-6 -174 C- (GG) genotypes showed a marked increase in one year follow-up mortality rate (HR=3.89, 95% CI 1.71-8.86, p=0.001). Moreover CRP serum levels ≥5.5 mg/dl (HR= 3.79, 95% CI 1.71-8.42, p=0.001), a history of CHD (HR=2.96, 95% CI 1.22-7.20, p=0.016) and the absence of statins treatment (HR=3.27, 95% CI 1.17-9.18, p=0.021), significantly increased one year risk of death in male ACS patients. Conclusions: These data suggest that IL-6 -174 G>C polymorphism can be added to other clinical markers in order to identify a subgroup of elderly ACS male patients at higher risk of death.

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalInternational Journal of Cardiology
Volume103
Issue number3
DOIs
Publication statusPublished - Sep 1 2005

Fingerprint

Acute Coronary Syndrome
Interleukin-6
Lymphotoxin-beta
Coronary Disease
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation Mediators
Unstable Angina
Genetic Promoter Regions
Survival Rate
Tumor Necrosis Factor-alpha
Biomarkers
Genotype
Gene Expression
Mortality
Serum

Keywords

  • Acute coronary syndrome
  • IL-6 polymorphism
  • Inflammation
  • TNF-α polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{4aaef600ec5b4918b0d747526d666abd,
title = "The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients",
abstract = "Background: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (-174 G>C) and TNF-α(-308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients. Methods: We assessed the IL-6 -174 G>C polymorphism and TNF-α -308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up. Results: We found that IL-6 -174 G>C polymorphism is an independent predictor of cardiovascular death after an ACS in male patients. In particular ACS patients carrying the IL-6 -174 C- (GG) genotypes showed a marked increase in one year follow-up mortality rate (HR=3.89, 95{\%} CI 1.71-8.86, p=0.001). Moreover CRP serum levels ≥5.5 mg/dl (HR= 3.79, 95{\%} CI 1.71-8.42, p=0.001), a history of CHD (HR=2.96, 95{\%} CI 1.22-7.20, p=0.016) and the absence of statins treatment (HR=3.27, 95{\%} CI 1.17-9.18, p=0.021), significantly increased one year risk of death in male ACS patients. Conclusions: These data suggest that IL-6 -174 G>C polymorphism can be added to other clinical markers in order to identify a subgroup of elderly ACS male patients at higher risk of death.",
keywords = "Acute coronary syndrome, IL-6 polymorphism, Inflammation, TNF-α polymorphism",
author = "Roberto Antonicelli and Fabiola Olivieri and Massimiliano Bonaf{\`e} and Luca Cavallone and Liana Spazzafumo and Francesca Marchegiani and Maurizio Cardelli and Andrea Recanatini and Paolo Testarmata and Massimo Boemi and Gianfranco Parati and Claudio Franceschi",
year = "2005",
month = "9",
day = "1",
doi = "10.1016/j.ijcard.2004.08.064",
language = "English",
volume = "103",
pages = "266--271",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

AU - Antonicelli, Roberto

AU - Olivieri, Fabiola

AU - Bonafè, Massimiliano

AU - Cavallone, Luca

AU - Spazzafumo, Liana

AU - Marchegiani, Francesca

AU - Cardelli, Maurizio

AU - Recanatini, Andrea

AU - Testarmata, Paolo

AU - Boemi, Massimo

AU - Parati, Gianfranco

AU - Franceschi, Claudio

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Background: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (-174 G>C) and TNF-α(-308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients. Methods: We assessed the IL-6 -174 G>C polymorphism and TNF-α -308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up. Results: We found that IL-6 -174 G>C polymorphism is an independent predictor of cardiovascular death after an ACS in male patients. In particular ACS patients carrying the IL-6 -174 C- (GG) genotypes showed a marked increase in one year follow-up mortality rate (HR=3.89, 95% CI 1.71-8.86, p=0.001). Moreover CRP serum levels ≥5.5 mg/dl (HR= 3.79, 95% CI 1.71-8.42, p=0.001), a history of CHD (HR=2.96, 95% CI 1.22-7.20, p=0.016) and the absence of statins treatment (HR=3.27, 95% CI 1.17-9.18, p=0.021), significantly increased one year risk of death in male ACS patients. Conclusions: These data suggest that IL-6 -174 G>C polymorphism can be added to other clinical markers in order to identify a subgroup of elderly ACS male patients at higher risk of death.

AB - Background: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are key mediators of inflammation and their increased plasma levels are associated with acute coronary syndrome (ACS). Polymorphisms in the promoter region of IL-6 (-174 G>C) and TNF-α(-308 G>A) demonstrated to affect gene expression were analyzed to test their predictive power for cardiovascular death over one year follow-up in elderly male ACS patients. Methods: We assessed the IL-6 -174 G>C polymorphism and TNF-α -308 G>A polymorphism in 139 consecutive elderly male patients affected by an ACS, such as ST-Elevation (STEMI), No ST-Elevation (NSTEMI) Myocardial Infarction and Unstable Angina. The presence of well known risk factors for Coronary Heart Diseases (CHD) were also assessed in all ACS patients. Survival rate was assessed after one year follow-up. Results: We found that IL-6 -174 G>C polymorphism is an independent predictor of cardiovascular death after an ACS in male patients. In particular ACS patients carrying the IL-6 -174 C- (GG) genotypes showed a marked increase in one year follow-up mortality rate (HR=3.89, 95% CI 1.71-8.86, p=0.001). Moreover CRP serum levels ≥5.5 mg/dl (HR= 3.79, 95% CI 1.71-8.42, p=0.001), a history of CHD (HR=2.96, 95% CI 1.22-7.20, p=0.016) and the absence of statins treatment (HR=3.27, 95% CI 1.17-9.18, p=0.021), significantly increased one year risk of death in male ACS patients. Conclusions: These data suggest that IL-6 -174 G>C polymorphism can be added to other clinical markers in order to identify a subgroup of elderly ACS male patients at higher risk of death.

KW - Acute coronary syndrome

KW - IL-6 polymorphism

KW - Inflammation

KW - TNF-α polymorphism

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U2 - 10.1016/j.ijcard.2004.08.064

DO - 10.1016/j.ijcard.2004.08.064

M3 - Article

VL - 103

SP - 266

EP - 271

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -