The interplay between uric acid and antioxidants in relation to physical function in older persons

Carmelinda Ruggiero, Antonio Cherubini, Jack Guralnik, Richard D. Semba, Marcello Maggio, Shari M. Ling, Fulvio Lauretani, Stefania Bandinelli, Umberto Senin, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To investigate the relationship between circulating uric acid (UA) levels and plasma antioxidants and whether antioxidant levels modulate the association between UA and physical function. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: Nine hundred sixty-six elderly persons participating in the baseline assessment of the Invecchiare in Chianti Study. MEASUREMENTS: UA, carotenoid, tocopherol, and selenium concentrations were assayed. Physical function was measured using the Short Physical Performance Battery (SPPB) and difficulties in instrumental activities of daily living (IADLs). Potential confounders were assessed using standardized methods. RESULTS: Total carotenoids (P=.008), in particular α-carotene (P=.02), lutein (P

Original languageEnglish
Pages (from-to)1206-1215
Number of pages10
JournalJournal of the American Geriatrics Society
Volume55
Issue number8
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Antioxidants
  • Disability
  • Inflammation
  • Metabolism
  • Physical function
  • Uric acid

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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