The INTERPRET-DD study of diabetes and depression: A protocol

C. E. Lloyd, N. Sartorius, L. C. Cimino, A. Alvarez, M. Guinzbourg De Braude, G. Rabbani, H. Uddin Ahmed, M. Papelbaum, S. Regina De Freitas, L. Ji, X. Yu, W. Gaebel, K. Müssig, S. K. Chaturvedi, S. S. Srikanta, L. Burti, V. Bulgari, A. Musau, D. Ndetei, G. HeinzeF. Romo Nava, R. Taj, A. Khan, A. Kokoszka, A. Papasz-Siemieniuk, E. G. Starostina, A. E. Bobrov, D. Lecic-Tosevski, N. M. Lalic, P. Udomratn, S. Tangwongchai, S. Bahendeka, D. Basangwa, B. Mankovsky

Research output: Contribution to journalArticlepeer-review


Aim People with diabetes are at an increased risk of developing depression and other psychological disorders. However, little is known about the prevalence, correlates or care pathways in countries other than the UK and the USA. A new study, the International Prevalence and Treatment of Diabetes and Depression Study (INTERPRET-DD) aims to address this dearth of knowledge and identify optimal pathways to care across the globe. Method INTERPRET-DD is a 2-year longitudinal study, taking place in 16 countries' diabetes outpatients' facilities, investigating the recognition and management of depressive disorders in people with Type 2 diabetes. Clinical interviews are used to diagnose depression, with clinical and other data obtained from medical records and through patient interviews. Pathways to care and the impact of treatment for previously unrecognized (undocumented) depression on clinical outcomes and emotional well-being are being investigated. Results Initial evidence indicates that a range of pathways to care exist, with few of them based on available recommendations for treatment. Pilot data indicates that the instruments we are using to measure both the symptoms and clinical diagnosis of depression are acceptable in our study population and easy to use. Conclusions Our study will increase the understanding of the impact of comorbid diabetes and depression and identify the most appropriate (country-specific) pathways via which patients receive their care. It addresses an important public health problem and leads to recommendations for best practice relevant to the different participating centres with regard to the identification and treatment of people with comorbid diabetes and depression.

Original languageEnglish
Pages (from-to)925-934
Number of pages10
JournalDiabetic Medicine
Issue number7
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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