The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study

C. M C Oude Ophuis; C. Verhoef; P. Rutkowski; B. W E M Powell; J. A. van der Hage; P. A M van Leeuwen; C. A. Voit; A. Testori; C. Robert; H. J. Hoekstra; D. J. Grünhagen; A. M M Eggermont; A. C J van Akkooi

doi:10.1016/j.ejso.2016.05.012

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study

C. M C Oude Ophuis, C. Verhoef, P. Rutkowski, B. W E M Powell, J. A. van der Hage, P. A M van Leeuwen, C. A. Voit, A. Testori, C. Robert, H. J. Hoekstra, D. J. Grünhagen, A. M M Eggermont, A. C J van Akkooi

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Worldwide, sentinel node biopsy (SNB) is the recommended staging procedure for stage I/II melanoma. Most melanoma guidelines recommend re-excision plus SNB as soon as possible after primary excision. To date, there is no evidence to support this timeframe. Aim: To determine melanoma specific survival (MSS) for time intervals between excisional biopsy and SNB in SNB positive patients. Methods: Between 1993 and 2008, 1080 patients were diagnosed with a positive SNB in nine Melanoma Group centers. We selected 1015 patients (94%) with known excisional biopsy date. Time interval was calculated from primary excision until SNB. Kaplan-Meier estimated MSS was calculated for different cutoff values. Multivariable analysis was performed to correct for known prognostic factors. Results: Median age was 51 years (Inter Quartile Range (IQR) 40-62 years), 535 (53%) were men, 603 (59%) primary tumors were located on extremities. Median Breslow thickness was 3.00 mm (IQR 1.90-4.80 mm), 442 (44%) were ulcerated. Median follow-up was 36 months (IQR 20-62 months). Median time interval was 47 days (IQR 32-63 days). Median Breslow thickness was equal for both

Original language	English
Journal	European Journal of Surgical Oncology
DOIs	https://doi.org/10.1016/j.ejso.2016.05.012
Publication status	Accepted/In press - 2016

Keywords

Cutaneous melanoma
Melanoma
Melanoma specific survival
Prognosis
Sentinel lymph node biopsy
Waiting list

ASJC Scopus subject areas

Oncology
Surgery

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Oude Ophuis, C. M. C., Verhoef, C., Rutkowski, P., Powell, B. W. E. M., van der Hage, J. A., van Leeuwen, P. A. M., Voit, C. A., Testori, A., Robert, C., Hoekstra, H. J., Grünhagen, D. J., Eggermont, A. M. M., & van Akkooi, A. C. J. (Accepted/In press). The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study. European Journal of Surgical Oncology. https://doi.org/10.1016/j.ejso.2016.05.012

The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study. / Oude Ophuis, C. M C; Verhoef, C.; Rutkowski, P.; Powell, B. W E M; van der Hage, J. A.; van Leeuwen, P. A M; Voit, C. A.; Testori, A.; Robert, C.; Hoekstra, H. J.; Grünhagen, D. J.; Eggermont, A. M M; van Akkooi, A. C J.

In: European Journal of Surgical Oncology, 2016.

Research output: Contribution to journal › Article › peer-review

Oude Ophuis, CMC, Verhoef, C, Rutkowski, P, Powell, BWEM, van der Hage, JA, van Leeuwen, PAM, Voit, CA, Testori, A, Robert, C, Hoekstra, HJ, Grünhagen, DJ, Eggermont, AMM & van Akkooi, ACJ 2016, 'The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study', European Journal of Surgical Oncology. https://doi.org/10.1016/j.ejso.2016.05.012

Oude Ophuis, C. M C ; Verhoef, C. ; Rutkowski, P. ; Powell, B. W E M ; van der Hage, J. A. ; van Leeuwen, P. A M ; Voit, C. A. ; Testori, A. ; Robert, C. ; Hoekstra, H. J. ; Grünhagen, D. J. ; Eggermont, A. M M ; van Akkooi, A. C J. / The interval between primary melanoma excision and sentinel node biopsy is not associated with survival in sentinel node positive patients - An EORTC Melanoma Group study. In: European Journal of Surgical Oncology. 2016.

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abstract = "Background: Worldwide, sentinel node biopsy (SNB) is the recommended staging procedure for stage I/II melanoma. Most melanoma guidelines recommend re-excision plus SNB as soon as possible after primary excision. To date, there is no evidence to support this timeframe. Aim: To determine melanoma specific survival (MSS) for time intervals between excisional biopsy and SNB in SNB positive patients. Methods: Between 1993 and 2008, 1080 patients were diagnosed with a positive SNB in nine Melanoma Group centers. We selected 1015 patients (94%) with known excisional biopsy date. Time interval was calculated from primary excision until SNB. Kaplan-Meier estimated MSS was calculated for different cutoff values. Multivariable analysis was performed to correct for known prognostic factors. Results: Median age was 51 years (Inter Quartile Range (IQR) 40-62 years), 535 (53%) were men, 603 (59%) primary tumors were located on extremities. Median Breslow thickness was 3.00 mm (IQR 1.90-4.80 mm), 442 (44%) were ulcerated. Median follow-up was 36 months (IQR 20-62 months). Median time interval was 47 days (IQR 32-63 days). Median Breslow thickness was equal for both ",

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AU - Oude Ophuis, C. M C

AU - Verhoef, C.

AU - Rutkowski, P.

AU - Powell, B. W E M

AU - van der Hage, J. A.

AU - van Leeuwen, P. A M

AU - Voit, C. A.

AU - Testori, A.

AU - Robert, C.

AU - Hoekstra, H. J.

AU - Grünhagen, D. J.

AU - Eggermont, A. M M

AU - van Akkooi, A. C J

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