The Intradermal Leishmanin Reaction Induces Antigen-specific Maturation of Canine Dendritic Cells with Up-regulation of MHCII Synthesis and Expression

L. Sacchi, L. E. Calvi, L. H. Kramer, E. Ferroglio, G. Grandi, E. Clementi, S. Corona

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that reside in many tissues, including the skin. This study showed that intradermal injection of leishmanin in Leishmania infantum-infected dogs induced the "up-regulation" of surface MHCII expression, associated with progressive ultrastrucutural changes characteristic of DC maturation, including the formation of multilaminar MHC class II-containing compartments and arrays of tubulo-vesicular structures. These changes were not observed in control dogs from L. infantum non-endemic areas. The results indicated that canine DCs were effector cells in delayed-type hypersensitivity, that the leishmanin reaction was specific for a cell-mediated reaction to L. infantum in infected dogs, and that canine DCs possessed ultrastructural organelles reminiscent of those in activated human DCs.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Comparative Pathology
Volume135
Issue number1
DOIs
Publication statusPublished - Jul 2006

Keywords

  • dendritic cells
  • dog
  • Leishmania infantum
  • leishmanin
  • MHCII
  • parasitic infection

ASJC Scopus subject areas

  • Animal Science and Zoology

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