The intravenous insulin tolerance test is an accurate method for screening a general population for insulin resistance and related abnormalities

S. Graci, R. Baratta, C. Degano, A. Iuppa, R. Vigneri, L. Frittitta, Vincenzo Trischitta

Research output: Contribution to journalArticle

Abstract

To verify whether the short intravenous insulin tolerance test (ITT) (a safe, reproducible, inexpensive, rapid and easy to perform measurement of insulin sensitivity) is a suitable test for insulin resistance screening in a general population, we measured in 60 non diabetic subjects, either non-obese (no. = 40) or obese (BMI > 28, no. = 20) the K of glucose disappearance from plasma after ITT (K(ITT)), plasma glucose (PG) and insulin (IRI) both fasting (FPG, FIRI) and at 120 min of OGTT (PG-120, IRI-120), and also triglycerides (Tg), cholesterol (Chol) and blood pressure (BP). Subjects were subdivided into quartiles according to K(ITT) values. Average FPG, PG-120, FIRI, IR1-120, Tg and Chol values were progressively increased, and average HDL/Chol was progressively decreased from quartile 1 (the most insulin sensitive) to 4 (the most insulin resistant) (p <0.05, by 1-way ANOVA test). Also BP was increased in the insulin resistant patients, but statistical significance was not reached. Three or more of the studied parameters (FPG and/or PG-120, FIRI and/or IRI-120, Tg, HDL/Chol, mean BP) were altered (below the worst 25°percentile) in 64% of subjects from quartile 4; none of the subjects in quartile 1 was affected by such a cluster of alterations. K(ITT) values ≤ 4.8 identified the cluster of insulin resistance related alterations with an accuracy of 82% (sensitivity = 83.3%, specificity = 80.5%). In healthy subjects with a wide range of BMI the ITT is a reliable procedure for screening for the cluster of metabolic alterations related to insulin resistance.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalJournal of Endocrinological Investigation
Volume22
Issue number6
Publication statusPublished - 1999

Keywords

  • Cardiovascular disease
  • Insulin resistance
  • Insulin tolerance test
  • Syndrome X

ASJC Scopus subject areas

  • Endocrinology

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