The intravenous insulin tolerance test is an accurate method for screening a general population for insulin resistance and related abnormalities

S. Graci, R. Baratta, C. Degano, A. Iuppa, R. Vigneri, L. Frittitta, Vincenzo Trischitta

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To verify whether the short intravenous insulin tolerance test (ITT) (a safe, reproducible, inexpensive, rapid and easy to perform measurement of insulin sensitivity) is a suitable test for insulin resistance screening in a general population, we measured in 60 non diabetic subjects, either non-obese (no. = 40) or obese (BMI > 28, no. = 20) the K of glucose disappearance from plasma after ITT (K(ITT)), plasma glucose (PG) and insulin (IRI) both fasting (FPG, FIRI) and at 120 min of OGTT (PG-120, IRI-120), and also triglycerides (Tg), cholesterol (Chol) and blood pressure (BP). Subjects were subdivided into quartiles according to K(ITT) values. Average FPG, PG-120, FIRI, IR1-120, Tg and Chol values were progressively increased, and average HDL/Chol was progressively decreased from quartile 1 (the most insulin sensitive) to 4 (the most insulin resistant) (p <0.05, by 1-way ANOVA test). Also BP was increased in the insulin resistant patients, but statistical significance was not reached. Three or more of the studied parameters (FPG and/or PG-120, FIRI and/or IRI-120, Tg, HDL/Chol, mean BP) were altered (below the worst 25°percentile) in 64% of subjects from quartile 4; none of the subjects in quartile 1 was affected by such a cluster of alterations. K(ITT) values ≤ 4.8 identified the cluster of insulin resistance related alterations with an accuracy of 82% (sensitivity = 83.3%, specificity = 80.5%). In healthy subjects with a wide range of BMI the ITT is a reliable procedure for screening for the cluster of metabolic alterations related to insulin resistance.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalJournal of Endocrinological Investigation
Volume22
Issue number6
Publication statusPublished - 1999

Fingerprint

Insulin Resistance
Insulin
Population
Glucose
Triglycerides
Glucose Tolerance Test
Blood Pressure
HDL Cholesterol
Cholesterol
Fasting
Analysis of Variance
Healthy Volunteers
Sensitivity and Specificity

Keywords

  • Cardiovascular disease
  • Insulin resistance
  • Insulin tolerance test
  • Syndrome X

ASJC Scopus subject areas

  • Endocrinology

Cite this

The intravenous insulin tolerance test is an accurate method for screening a general population for insulin resistance and related abnormalities. / Graci, S.; Baratta, R.; Degano, C.; Iuppa, A.; Vigneri, R.; Frittitta, L.; Trischitta, Vincenzo.

In: Journal of Endocrinological Investigation, Vol. 22, No. 6, 1999, p. 472-475.

Research output: Contribution to journalArticle

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