The Intriguing Role of Neuropeptides at the Ocular Surface

Francesco Sabatino, Antonio Di Zazzo, Luca De Simone, Stefano Bonini

Research output: Contribution to journalReview articlepeer-review


In recent decades, the role of neuropeptides in physiology and pathology has been elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate the crosstalk between immune and nervous systems. They actively regulate trophic and immune functions and orchestrate neuroinflammation. The purpose of this manuscript is to review the expression of the neuropeptides SP, VIP, CGRP, and NPY at the ocular surface, focusing on their role in tropism and immunity, and to summarize their functions in ocular immune privilege, infection, dry eye, and allergic eye disease.

Original languageEnglish
Pages (from-to)2-14
Number of pages13
JournalOcular Surface
Issue number1
Publication statusPublished - Jan 1 2017


  • allergic eye disease
  • dry eye
  • neuropeptides

ASJC Scopus subject areas

  • Ophthalmology


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