The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age: A longitudinal study

U. Pelosi, G. Porcedda, F. Tiddia, S. Tripodi, A. E. Tozzi, V. Panetta, C. Pintor, Paolo Maria Matricardi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Respiratory allergies are inversely related to early acquisition of food-borne and fecal-oral infections, consumption of unpasteurized milk, early exposure to stables and high endotoxin concentrations in a farming environment. We tested therefore if infection by Salmonella in early life can protect from development of respiratory allergies later in life. Methods: During 2003, we studied two groups of Sardinian children (age 6-18 years) who had been hospitalized before 4 years of age (during 1989-2001) with non-typhoid salmonellosis (n = 148) or acute enteritis of nonbacterial etiology (NB-enteritis) (n = 167). Allergic rhinoconjunctivitis (AR) and asthma were evaluated by telephonic interview with a ISAAC questionnaire; participants reporting AR and/or asthma were further examined through a complete diagnostic work-up to objectively confirm or exclude current disease, Kaplan-Meier curves and Cox proportional hazard models were used to analyze the role of different types of enteritis on the risk of developing allergic rhinoconjunctivitis or asthma over time. Results: Children who had been hospitalized with salmonellosis had a lower prevalence of allergic rhinoconjunctivitis (eight of 148, 5.4% vs 23 of 167, 13.8%; P = 0.019) or asthma (five of 148, 3.4% vs 21 of 167, 12.6%; P = 0.006) than those who had been hospitalized with NB-enteritis. The proportional hazard of salmonellosis for asthma was 0.23 (95% CI: 0.08-0.67; P <0.01) and for allergic rhinoconjunctivitis was 0.40 (95% CI: 0.17-0.95; P = 0.04), after adjusting for confounders. Discussion: The strength of the observed associations suggests that Salmonella may contribute to shape the natural history of respiratory allergies. However, further studies are needed to test in other settings the association observed in Sardinian children. We speculate that clinical or subclinical infection by Salmonella may contribute to the atopy protective influence of a traditional farming environment or of areas endemic for food-borne and fecal-oral infections. Food hygiene and prevention of salmonellosis must remain however a public health priority.

Original languageEnglish
Pages (from-to)626-630
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume60
Issue number5
DOIs
Publication statusPublished - May 2005

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Salmonella Infections
Enteritis
Longitudinal Studies
Asthma
Hypersensitivity
Agriculture
Salmonella
Food
Health Priorities
Asymptomatic Infections
Infection
Hygiene
Proportional Hazards Models
Endotoxins
Milk
Public Health
Interviews

Keywords

  • Allergic rhinoconjunctivitis
  • Asthma
  • Endotoxin
  • Hygiene hypothesis
  • Salmonella

ASJC Scopus subject areas

  • Immunology

Cite this

The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age : A longitudinal study. / Pelosi, U.; Porcedda, G.; Tiddia, F.; Tripodi, S.; Tozzi, A. E.; Panetta, V.; Pintor, C.; Matricardi, Paolo Maria.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 60, No. 5, 05.2005, p. 626-630.

Research output: Contribution to journalArticle

Pelosi, U. ; Porcedda, G. ; Tiddia, F. ; Tripodi, S. ; Tozzi, A. E. ; Panetta, V. ; Pintor, C. ; Matricardi, Paolo Maria. / The inverse association of salmonellosis in infancy with allergic rhinoconjunctivitis and asthma at school-age : A longitudinal study. In: Allergy: European Journal of Allergy and Clinical Immunology. 2005 ; Vol. 60, No. 5. pp. 626-630.
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abstract = "Background: Respiratory allergies are inversely related to early acquisition of food-borne and fecal-oral infections, consumption of unpasteurized milk, early exposure to stables and high endotoxin concentrations in a farming environment. We tested therefore if infection by Salmonella in early life can protect from development of respiratory allergies later in life. Methods: During 2003, we studied two groups of Sardinian children (age 6-18 years) who had been hospitalized before 4 years of age (during 1989-2001) with non-typhoid salmonellosis (n = 148) or acute enteritis of nonbacterial etiology (NB-enteritis) (n = 167). Allergic rhinoconjunctivitis (AR) and asthma were evaluated by telephonic interview with a ISAAC questionnaire; participants reporting AR and/or asthma were further examined through a complete diagnostic work-up to objectively confirm or exclude current disease, Kaplan-Meier curves and Cox proportional hazard models were used to analyze the role of different types of enteritis on the risk of developing allergic rhinoconjunctivitis or asthma over time. Results: Children who had been hospitalized with salmonellosis had a lower prevalence of allergic rhinoconjunctivitis (eight of 148, 5.4{\%} vs 23 of 167, 13.8{\%}; P = 0.019) or asthma (five of 148, 3.4{\%} vs 21 of 167, 12.6{\%}; P = 0.006) than those who had been hospitalized with NB-enteritis. The proportional hazard of salmonellosis for asthma was 0.23 (95{\%} CI: 0.08-0.67; P <0.01) and for allergic rhinoconjunctivitis was 0.40 (95{\%} CI: 0.17-0.95; P = 0.04), after adjusting for confounders. Discussion: The strength of the observed associations suggests that Salmonella may contribute to shape the natural history of respiratory allergies. However, further studies are needed to test in other settings the association observed in Sardinian children. We speculate that clinical or subclinical infection by Salmonella may contribute to the atopy protective influence of a traditional farming environment or of areas endemic for food-borne and fecal-oral infections. Food hygiene and prevention of salmonellosis must remain however a public health priority.",
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AU - Pelosi, U.

AU - Porcedda, G.

AU - Tiddia, F.

AU - Tripodi, S.

AU - Tozzi, A. E.

AU - Panetta, V.

AU - Pintor, C.

AU - Matricardi, Paolo Maria

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N2 - Background: Respiratory allergies are inversely related to early acquisition of food-borne and fecal-oral infections, consumption of unpasteurized milk, early exposure to stables and high endotoxin concentrations in a farming environment. We tested therefore if infection by Salmonella in early life can protect from development of respiratory allergies later in life. Methods: During 2003, we studied two groups of Sardinian children (age 6-18 years) who had been hospitalized before 4 years of age (during 1989-2001) with non-typhoid salmonellosis (n = 148) or acute enteritis of nonbacterial etiology (NB-enteritis) (n = 167). Allergic rhinoconjunctivitis (AR) and asthma were evaluated by telephonic interview with a ISAAC questionnaire; participants reporting AR and/or asthma were further examined through a complete diagnostic work-up to objectively confirm or exclude current disease, Kaplan-Meier curves and Cox proportional hazard models were used to analyze the role of different types of enteritis on the risk of developing allergic rhinoconjunctivitis or asthma over time. Results: Children who had been hospitalized with salmonellosis had a lower prevalence of allergic rhinoconjunctivitis (eight of 148, 5.4% vs 23 of 167, 13.8%; P = 0.019) or asthma (five of 148, 3.4% vs 21 of 167, 12.6%; P = 0.006) than those who had been hospitalized with NB-enteritis. The proportional hazard of salmonellosis for asthma was 0.23 (95% CI: 0.08-0.67; P <0.01) and for allergic rhinoconjunctivitis was 0.40 (95% CI: 0.17-0.95; P = 0.04), after adjusting for confounders. Discussion: The strength of the observed associations suggests that Salmonella may contribute to shape the natural history of respiratory allergies. However, further studies are needed to test in other settings the association observed in Sardinian children. We speculate that clinical or subclinical infection by Salmonella may contribute to the atopy protective influence of a traditional farming environment or of areas endemic for food-borne and fecal-oral infections. Food hygiene and prevention of salmonellosis must remain however a public health priority.

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