The involvement of endothelial progenitor cells in tumor angiogenesis

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain rumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Volume8
Issue number3
Publication statusPublished - Jul 2004

Keywords

  • Angiogenesis
  • Endothelial progenitor cells
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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