Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain rumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.
|Number of pages||7|
|Journal||Journal of Cellular and Molecular Medicine|
|Publication status||Published - Jul 2004|
- Endothelial progenitor cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)