The Italian Brain Normative Archive of structural MR scans: Norms for medial temporal atrophy and white matter lesions

Samantha Galluzzi, Cristina Testa, Marina Boccardi, Lorena Bresciani, Luisa Benussi, Roberta Ghidoni, Alberto Beltramello, Matteo Bonetti, Giorgio Bono, Andrea Falini, Giuseppe Magnani, Giorgio Minonzio, Enrico Piovan, Giuliano Binetti, Giovanni B. Frisoni

Research output: Contribution to journalArticlepeer-review


Background and aims: To describe the clinical and neuropsychological features of a large group of cognitively intact persons subjected to brain high-resolution magnetic resonance (MR), to compare them with the general population, and to set norms for medial temporal atrophy and white matter lesions. Methods: Participants in the Italian Brain Normative Archive (IBNA) study were 483 consecutive volunteers undergoing MR for reasons unrelated to cognition (migraine or headache, visual and balance or auditory disturbances, paresthesias, and others) and showing no brain damage. Manual tracing of hippocampal and amygdalar volumes and visual rating of white matter lesions were made. The whole study group was stratified by age (≤60 and 60+ yrs) and by the reason for MR prescription. Results: In the whole group, mean age and education were 52.4±13.7 and 9.8±4.2 years, respectively, and the prevalence of women was 63%. Clinical, neuropsychological and morphometric features were similar in the stratified subgroups. Neuropsychological features were those expected for age and education based on Italian normative values. Hippocampal and amygdalar volumes were not associated with age, except for the right amygdala (B -0.159, 95% CI -0.28 to -0.03, p=0.016). Conclusions: Persons in the IBNA study had clinical and neuropsychological features consistent with that of the general population. Their brain morphometric features may be used as normative references for patients with suspected neurodegenerative disorders.

Original languageEnglish
Pages (from-to)266-276
Number of pages11
JournalAging clinical and experimental research
Issue number4-5
Publication statusPublished - Aug 2009


  • Amygdalar volume
  • Healthy persons
  • Hippocampal volume
  • Normative
  • White matter lesions

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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