The Italian dementia with Lewy bodies study group (DLB-SINdem)

toward a standardization of clinical procedures and multicenter cohort studies design

Laura Bonanni, Annachiara Cagnin, Federica Agosta, Claudio Babiloni, B. Borroni, Marco Bozzali, Amalia C. Bruni, Massimo Filippi, Daniela Galimberti, R. Monastero, Cristina Muscio, Lucilla Parnetti, Daniela Perani, Laura Serra, Vincenzo Silani, Pietro Tiraboschi, A. Padovani, A. Alberici, Margherita Alberoni, Serena Amici & 143 others I. M. Appollonio, M. G. Arena, Andrea Arighi, Stefano Avanzi, Caterina F. Bagella, Francesca Baglio, F. Barocco, N. Belardinelli, U. Bonuccelli, G. Bottini, R. Bruno Bossio, G. Bruno, D. Buccomino, Gabriella Cacchiò, Elena Sabatina Calabrese, A. Campanelli, M. Canevelli, E. Canu, A. Cappa, C. Capra, E. Carapelle, S. Caratozzolo, G. F S Carbone, Tatiana Cattaruzza, Chiara Cerami, A. Cester, Antonella Cheldi, R. Cherchi, A. Chiari, C. Cirafisi, Rosanna Colao, A. Confaloni, M. Z. Conti, Alberto Costa, Bruno Costa, Maria Cotelli, Ilaria Cova, Luca Cravello, E. Cumbo, Chiara Cupidi, L. de Togni, G. Del Din, M. L. Del Re, C. Dentizzi, F. Di Lorenzo, Francesca Di Stefano, N. Dikova, Elisabetta Farina, Gianluca Floris, A. Foti, Massimo Franceschi, Giorgio Giulio Fumagalli, Carlo Gabelli, E. Ghidoni, David Giannandrea, M. T. Giordana, M. Giorelli, F. Giubilei, L. M E Grimaldi, R. Grimaldi, V. Guglielmi, Alessia Lanari, Francesco Le Pira, F. Letteri, G. V. Levi Minzi, S. Lorusso, L. Ludovico, Simona Luzzi, Laura Maggiore, Giuseppe Magnani, G. Mancini, F. M. Manconi, Luigi Manfredi, M. Maniscalco, P. Marano, M. Marcon, A. Marcone, C. Marra, A. Martorana, M. G. Mascia, V. Mascia, Margherita Mauri, B. Mazzei, M. Meloni, P. Merlo, G. Messa, A. Milia, Fiammetta Monacelli, G. Montecalvo, V. Moschella, G. Mura, Raffaello Nemni, Flavio Nobili, Antonella Notarelli, R. Di Giacomo, M. Onofrj, C. Paci, Chiara Padiglioni, M. Perini, D. Perotta, F. A. Perri, Roberta Perri, C. Piccininni, T. Piccoli, G. Pilia, Andrea Pilotto, S. Poli, Simone Pomati, Sara Pompanin, E. Pucci, Gianfranco Puccio, D. Quaranta, Innocenzo Rainero, G. Rea, Sabrina Realmuto, M. Riva, Maria Cristina Rizzetti, Giuseppe Rolma, L. Rozzini, Leonardo Sacco, Francesca Lea Saibene, Elio Angelo Scarpini, S. Sensi, Davide Seripa, Elena Sinforiani, S. Sorbi, Giuseppe Sorrentino, Marco Spallazzi, A. Stracciari, G. Talarico, Tiziana Tassinari, Astrid Thomas, A. Tiezzi, Pia Francesca Tomassini, Alessandro Trebbastoni, Lucio Tremolizzo, G. Tripi, Francesca Ursini, L. Vaianella, Francesco Valluzzi, Giuliana Vezzadini, M. Vista, Maria Antonietta Volontè

Research output: Contribution to journalArticle

Abstract

Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients’ reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer’s disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 %) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 %) than that of Alzheimer’s disease and frontotemporal dementia (56 ± 27 %) patients. The majority of the centers (91 %) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 %), electroencephalography (EEG; 93 %), and FP-CIT single photon emission-computerized tomography (SPECT; 75 %) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Sep 13 2016

Fingerprint

Lewy Body Disease
Multicenter Studies
Cohort Studies
Single-Photon Emission-Computed Tomography
Longitudinal Studies
Dementia
Electroencephalography
Alzheimer Disease
Frontotemporal Dementia
Institutionalization
Delirium
Diagnostic Errors
Hospitalization
Quality of Life
Magnetic Resonance Imaging
Pharmacology
Mortality
Incidence
Health
Therapeutics

Keywords

  • Dementia with Lewy bodies
  • Standardization of diagnostic procedures
  • Survey

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

The Italian dementia with Lewy bodies study group (DLB-SINdem) : toward a standardization of clinical procedures and multicenter cohort studies design. / Bonanni, Laura; Cagnin, Annachiara; Agosta, Federica; Babiloni, Claudio; Borroni, B.; Bozzali, Marco; Bruni, Amalia C.; Filippi, Massimo; Galimberti, Daniela; Monastero, R.; Muscio, Cristina; Parnetti, Lucilla; Perani, Daniela; Serra, Laura; Silani, Vincenzo; Tiraboschi, Pietro; Padovani, A.; Alberici, A.; Alberoni, Margherita; Amici, Serena; Appollonio, I. M.; Arena, M. G.; Arighi, Andrea; Avanzi, Stefano; Bagella, Caterina F.; Baglio, Francesca; Barocco, F.; Belardinelli, N.; Bonuccelli, U.; Bottini, G.; Bruno Bossio, R.; Bruno, G.; Buccomino, D.; Cacchiò, Gabriella; Calabrese, Elena Sabatina; Campanelli, A.; Canevelli, M.; Canu, E.; Cappa, A.; Capra, C.; Carapelle, E.; Caratozzolo, S.; Carbone, G. F S; Cattaruzza, Tatiana; Cerami, Chiara; Cester, A.; Cheldi, Antonella; Cherchi, R.; Chiari, A.; Cirafisi, C.; Colao, Rosanna; Confaloni, A.; Conti, M. Z.; Costa, Alberto; Costa, Bruno; Cotelli, Maria; Cova, Ilaria; Cravello, Luca; Cumbo, E.; Cupidi, Chiara; de Togni, L.; Del Din, G.; Del Re, M. L.; Dentizzi, C.; Di Lorenzo, F.; Di Stefano, Francesca; Dikova, N.; Farina, Elisabetta; Floris, Gianluca; Foti, A.; Franceschi, Massimo; Fumagalli, Giorgio Giulio; Gabelli, Carlo; Ghidoni, E.; Giannandrea, David; Giordana, M. T.; Giorelli, M.; Giubilei, F.; Grimaldi, L. M E; Grimaldi, R.; Guglielmi, V.; Lanari, Alessia; Le Pira, Francesco; Letteri, F.; Levi Minzi, G. V.; Lorusso, S.; Ludovico, L.; Luzzi, Simona; Maggiore, Laura; Magnani, Giuseppe; Mancini, G.; Manconi, F. M.; Manfredi, Luigi; Maniscalco, M.; Marano, P.; Marcon, M.; Marcone, A.; Marra, C.; Martorana, A.; Mascia, M. G.; Mascia, V.; Mauri, Margherita; Mazzei, B.; Meloni, M.; Merlo, P.; Messa, G.; Milia, A.; Monacelli, Fiammetta; Montecalvo, G.; Moschella, V.; Mura, G.; Nemni, Raffaello; Nobili, Flavio; Notarelli, Antonella; Di Giacomo, R.; Onofrj, M.; Paci, C.; Padiglioni, Chiara; Perini, M.; Perotta, D.; Perri, F. A.; Perri, Roberta; Piccininni, C.; Piccoli, T.; Pilia, G.; Pilotto, Andrea; Poli, S.; Pomati, Simone; Pompanin, Sara; Pucci, E.; Puccio, Gianfranco; Quaranta, D.; Rainero, Innocenzo; Rea, G.; Realmuto, Sabrina; Riva, M.; Rizzetti, Maria Cristina; Rolma, Giuseppe; Rozzini, L.; Sacco, Leonardo; Saibene, Francesca Lea; Scarpini, Elio Angelo; Sensi, S.; Seripa, Davide; Sinforiani, Elena; Sorbi, S.; Sorrentino, Giuseppe; Spallazzi, Marco; Stracciari, A.; Talarico, G.; Tassinari, Tiziana; Thomas, Astrid; Tiezzi, A.; Tomassini, Pia Francesca; Trebbastoni, Alessandro; Tremolizzo, Lucio; Tripi, G.; Ursini, Francesca; Vaianella, L.; Valluzzi, Francesco; Vezzadini, Giuliana; Vista, M.; Volontè, Maria Antonietta.

In: Neurological Sciences, 13.09.2016, p. 1-9.

Research output: Contribution to journalArticle

Bonanni, L, Cagnin, A, Agosta, F, Babiloni, C, Borroni, B, Bozzali, M, Bruni, AC, Filippi, M, Galimberti, D, Monastero, R, Muscio, C, Parnetti, L, Perani, D, Serra, L, Silani, V, Tiraboschi, P, Padovani, A, Alberici, A, Alberoni, M, Amici, S, Appollonio, IM, Arena, MG, Arighi, A, Avanzi, S, Bagella, CF, Baglio, F, Barocco, F, Belardinelli, N, Bonuccelli, U, Bottini, G, Bruno Bossio, R, Bruno, G, Buccomino, D, Cacchiò, G, Calabrese, ES, Campanelli, A, Canevelli, M, Canu, E, Cappa, A, Capra, C, Carapelle, E, Caratozzolo, S, Carbone, GFS, Cattaruzza, T, Cerami, C, Cester, A, Cheldi, A, Cherchi, R, Chiari, A, Cirafisi, C, Colao, R, Confaloni, A, Conti, MZ, Costa, A, Costa, B, Cotelli, M, Cova, I, Cravello, L, Cumbo, E, Cupidi, C, de Togni, L, Del Din, G, Del Re, ML, Dentizzi, C, Di Lorenzo, F, Di Stefano, F, Dikova, N, Farina, E, Floris, G, Foti, A, Franceschi, M, Fumagalli, GG, Gabelli, C, Ghidoni, E, Giannandrea, D, Giordana, MT, Giorelli, M, Giubilei, F, Grimaldi, LME, Grimaldi, R, Guglielmi, V, Lanari, A, Le Pira, F, Letteri, F, Levi Minzi, GV, Lorusso, S, Ludovico, L, Luzzi, S, Maggiore, L, Magnani, G, Mancini, G, Manconi, FM, Manfredi, L, Maniscalco, M, Marano, P, Marcon, M, Marcone, A, Marra, C, Martorana, A, Mascia, MG, Mascia, V, Mauri, M, Mazzei, B, Meloni, M, Merlo, P, Messa, G, Milia, A, Monacelli, F, Montecalvo, G, Moschella, V, Mura, G, Nemni, R, Nobili, F, Notarelli, A, Di Giacomo, R, Onofrj, M, Paci, C, Padiglioni, C, Perini, M, Perotta, D, Perri, FA, Perri, R, Piccininni, C, Piccoli, T, Pilia, G, Pilotto, A, Poli, S, Pomati, S, Pompanin, S, Pucci, E, Puccio, G, Quaranta, D, Rainero, I, Rea, G, Realmuto, S, Riva, M, Rizzetti, MC, Rolma, G, Rozzini, L, Sacco, L, Saibene, FL, Scarpini, EA, Sensi, S, Seripa, D, Sinforiani, E, Sorbi, S, Sorrentino, G, Spallazzi, M, Stracciari, A, Talarico, G, Tassinari, T, Thomas, A, Tiezzi, A, Tomassini, PF, Trebbastoni, A, Tremolizzo, L, Tripi, G, Ursini, F, Vaianella, L, Valluzzi, F, Vezzadini, G, Vista, M & Volontè, MA 2016, 'The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design', Neurological Sciences, pp. 1-9. https://doi.org/10.1007/s10072-016-2713-8
Bonanni, Laura ; Cagnin, Annachiara ; Agosta, Federica ; Babiloni, Claudio ; Borroni, B. ; Bozzali, Marco ; Bruni, Amalia C. ; Filippi, Massimo ; Galimberti, Daniela ; Monastero, R. ; Muscio, Cristina ; Parnetti, Lucilla ; Perani, Daniela ; Serra, Laura ; Silani, Vincenzo ; Tiraboschi, Pietro ; Padovani, A. ; Alberici, A. ; Alberoni, Margherita ; Amici, Serena ; Appollonio, I. M. ; Arena, M. G. ; Arighi, Andrea ; Avanzi, Stefano ; Bagella, Caterina F. ; Baglio, Francesca ; Barocco, F. ; Belardinelli, N. ; Bonuccelli, U. ; Bottini, G. ; Bruno Bossio, R. ; Bruno, G. ; Buccomino, D. ; Cacchiò, Gabriella ; Calabrese, Elena Sabatina ; Campanelli, A. ; Canevelli, M. ; Canu, E. ; Cappa, A. ; Capra, C. ; Carapelle, E. ; Caratozzolo, S. ; Carbone, G. F S ; Cattaruzza, Tatiana ; Cerami, Chiara ; Cester, A. ; Cheldi, Antonella ; Cherchi, R. ; Chiari, A. ; Cirafisi, C. ; Colao, Rosanna ; Confaloni, A. ; Conti, M. Z. ; Costa, Alberto ; Costa, Bruno ; Cotelli, Maria ; Cova, Ilaria ; Cravello, Luca ; Cumbo, E. ; Cupidi, Chiara ; de Togni, L. ; Del Din, G. ; Del Re, M. L. ; Dentizzi, C. ; Di Lorenzo, F. ; Di Stefano, Francesca ; Dikova, N. ; Farina, Elisabetta ; Floris, Gianluca ; Foti, A. ; Franceschi, Massimo ; Fumagalli, Giorgio Giulio ; Gabelli, Carlo ; Ghidoni, E. ; Giannandrea, David ; Giordana, M. T. ; Giorelli, M. ; Giubilei, F. ; Grimaldi, L. M E ; Grimaldi, R. ; Guglielmi, V. ; Lanari, Alessia ; Le Pira, Francesco ; Letteri, F. ; Levi Minzi, G. V. ; Lorusso, S. ; Ludovico, L. ; Luzzi, Simona ; Maggiore, Laura ; Magnani, Giuseppe ; Mancini, G. ; Manconi, F. M. ; Manfredi, Luigi ; Maniscalco, M. ; Marano, P. ; Marcon, M. ; Marcone, A. ; Marra, C. ; Martorana, A. ; Mascia, M. G. ; Mascia, V. ; Mauri, Margherita ; Mazzei, B. ; Meloni, M. ; Merlo, P. ; Messa, G. ; Milia, A. ; Monacelli, Fiammetta ; Montecalvo, G. ; Moschella, V. ; Mura, G. ; Nemni, Raffaello ; Nobili, Flavio ; Notarelli, Antonella ; Di Giacomo, R. ; Onofrj, M. ; Paci, C. ; Padiglioni, Chiara ; Perini, M. ; Perotta, D. ; Perri, F. A. ; Perri, Roberta ; Piccininni, C. ; Piccoli, T. ; Pilia, G. ; Pilotto, Andrea ; Poli, S. ; Pomati, Simone ; Pompanin, Sara ; Pucci, E. ; Puccio, Gianfranco ; Quaranta, D. ; Rainero, Innocenzo ; Rea, G. ; Realmuto, Sabrina ; Riva, M. ; Rizzetti, Maria Cristina ; Rolma, Giuseppe ; Rozzini, L. ; Sacco, Leonardo ; Saibene, Francesca Lea ; Scarpini, Elio Angelo ; Sensi, S. ; Seripa, Davide ; Sinforiani, Elena ; Sorbi, S. ; Sorrentino, Giuseppe ; Spallazzi, Marco ; Stracciari, A. ; Talarico, G. ; Tassinari, Tiziana ; Thomas, Astrid ; Tiezzi, A. ; Tomassini, Pia Francesca ; Trebbastoni, Alessandro ; Tremolizzo, Lucio ; Tripi, G. ; Ursini, Francesca ; Vaianella, L. ; Valluzzi, Francesco ; Vezzadini, Giuliana ; Vista, M. ; Volontè, Maria Antonietta. / The Italian dementia with Lewy bodies study group (DLB-SINdem) : toward a standardization of clinical procedures and multicenter cohort studies design. In: Neurological Sciences. 2016 ; pp. 1-9.
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title = "The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design",
abstract = "Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients’ reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer’s disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 {\%}) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 {\%}) than that of Alzheimer’s disease and frontotemporal dementia (56 ± 27 {\%}) patients. The majority of the centers (91 {\%}) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 {\%}), electroencephalography (EEG; 93 {\%}), and FP-CIT single photon emission-computerized tomography (SPECT; 75 {\%}) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.",
keywords = "Dementia with Lewy bodies, Standardization of diagnostic procedures, Survey",
author = "Laura Bonanni and Annachiara Cagnin and Federica Agosta and Claudio Babiloni and B. Borroni and Marco Bozzali and Bruni, {Amalia C.} and Massimo Filippi and Daniela Galimberti and R. Monastero and Cristina Muscio and Lucilla Parnetti and Daniela Perani and Laura Serra and Vincenzo Silani and Pietro Tiraboschi and A. Padovani and A. Alberici and Margherita Alberoni and Serena Amici and Appollonio, {I. M.} and Arena, {M. G.} and Andrea Arighi and Stefano Avanzi and Bagella, {Caterina F.} and Francesca Baglio and F. Barocco and N. Belardinelli and U. Bonuccelli and G. Bottini and {Bruno Bossio}, R. and G. Bruno and D. Buccomino and Gabriella Cacchi{\`o} and Calabrese, {Elena Sabatina} and A. Campanelli and M. Canevelli and E. Canu and A. Cappa and C. Capra and E. Carapelle and S. Caratozzolo and Carbone, {G. F S} and Tatiana Cattaruzza and Chiara Cerami and A. Cester and Antonella Cheldi and R. Cherchi and A. Chiari and C. Cirafisi and Rosanna Colao and A. Confaloni and Conti, {M. Z.} and Alberto Costa and Bruno Costa and Maria Cotelli and Ilaria Cova and Luca Cravello and E. Cumbo and Chiara Cupidi and {de Togni}, L. and {Del Din}, G. and {Del Re}, {M. L.} and C. Dentizzi and {Di Lorenzo}, F. and {Di Stefano}, Francesca and N. Dikova and Elisabetta Farina and Gianluca Floris and A. Foti and Massimo Franceschi and Fumagalli, {Giorgio Giulio} and Carlo Gabelli and E. Ghidoni and David Giannandrea and Giordana, {M. T.} and M. Giorelli and F. Giubilei and Grimaldi, {L. M E} and R. Grimaldi and V. Guglielmi and Alessia Lanari and {Le Pira}, Francesco and F. Letteri and {Levi Minzi}, {G. V.} and S. Lorusso and L. Ludovico and Simona Luzzi and Laura Maggiore and Giuseppe Magnani and G. Mancini and Manconi, {F. M.} and Luigi Manfredi and M. Maniscalco and P. Marano and M. Marcon and A. Marcone and C. Marra and A. Martorana and Mascia, {M. G.} and V. Mascia and Margherita Mauri and B. Mazzei and M. Meloni and P. Merlo and G. Messa and A. Milia and Fiammetta Monacelli and G. Montecalvo and V. Moschella and G. Mura and Raffaello Nemni and Flavio Nobili and Antonella Notarelli and {Di Giacomo}, R. and M. Onofrj and C. Paci and Chiara Padiglioni and M. Perini and D. Perotta and Perri, {F. A.} and Roberta Perri and C. Piccininni and T. Piccoli and G. Pilia and Andrea Pilotto and S. Poli and Simone Pomati and Sara Pompanin and E. Pucci and Gianfranco Puccio and D. Quaranta and Innocenzo Rainero and G. Rea and Sabrina Realmuto and M. Riva and Rizzetti, {Maria Cristina} and Giuseppe Rolma and L. Rozzini and Leonardo Sacco and Saibene, {Francesca Lea} and Scarpini, {Elio Angelo} and S. Sensi and Davide Seripa and Elena Sinforiani and S. Sorbi and Giuseppe Sorrentino and Marco Spallazzi and A. Stracciari and G. Talarico and Tiziana Tassinari and Astrid Thomas and A. Tiezzi and Tomassini, {Pia Francesca} and Alessandro Trebbastoni and Lucio Tremolizzo and G. Tripi and Francesca Ursini and L. Vaianella and Francesco Valluzzi and Giuliana Vezzadini and M. Vista and Volont{\`e}, {Maria Antonietta}",
year = "2016",
month = "9",
day = "13",
doi = "10.1007/s10072-016-2713-8",
language = "English",
pages = "1--9",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",

}

TY - JOUR

T1 - The Italian dementia with Lewy bodies study group (DLB-SINdem)

T2 - toward a standardization of clinical procedures and multicenter cohort studies design

AU - Bonanni, Laura

AU - Cagnin, Annachiara

AU - Agosta, Federica

AU - Babiloni, Claudio

AU - Borroni, B.

AU - Bozzali, Marco

AU - Bruni, Amalia C.

AU - Filippi, Massimo

AU - Galimberti, Daniela

AU - Monastero, R.

AU - Muscio, Cristina

AU - Parnetti, Lucilla

AU - Perani, Daniela

AU - Serra, Laura

AU - Silani, Vincenzo

AU - Tiraboschi, Pietro

AU - Padovani, A.

AU - Alberici, A.

AU - Alberoni, Margherita

AU - Amici, Serena

AU - Appollonio, I. M.

AU - Arena, M. G.

AU - Arighi, Andrea

AU - Avanzi, Stefano

AU - Bagella, Caterina F.

AU - Baglio, Francesca

AU - Barocco, F.

AU - Belardinelli, N.

AU - Bonuccelli, U.

AU - Bottini, G.

AU - Bruno Bossio, R.

AU - Bruno, G.

AU - Buccomino, D.

AU - Cacchiò, Gabriella

AU - Calabrese, Elena Sabatina

AU - Campanelli, A.

AU - Canevelli, M.

AU - Canu, E.

AU - Cappa, A.

AU - Capra, C.

AU - Carapelle, E.

AU - Caratozzolo, S.

AU - Carbone, G. F S

AU - Cattaruzza, Tatiana

AU - Cerami, Chiara

AU - Cester, A.

AU - Cheldi, Antonella

AU - Cherchi, R.

AU - Chiari, A.

AU - Cirafisi, C.

AU - Colao, Rosanna

AU - Confaloni, A.

AU - Conti, M. Z.

AU - Costa, Alberto

AU - Costa, Bruno

AU - Cotelli, Maria

AU - Cova, Ilaria

AU - Cravello, Luca

AU - Cumbo, E.

AU - Cupidi, Chiara

AU - de Togni, L.

AU - Del Din, G.

AU - Del Re, M. L.

AU - Dentizzi, C.

AU - Di Lorenzo, F.

AU - Di Stefano, Francesca

AU - Dikova, N.

AU - Farina, Elisabetta

AU - Floris, Gianluca

AU - Foti, A.

AU - Franceschi, Massimo

AU - Fumagalli, Giorgio Giulio

AU - Gabelli, Carlo

AU - Ghidoni, E.

AU - Giannandrea, David

AU - Giordana, M. T.

AU - Giorelli, M.

AU - Giubilei, F.

AU - Grimaldi, L. M E

AU - Grimaldi, R.

AU - Guglielmi, V.

AU - Lanari, Alessia

AU - Le Pira, Francesco

AU - Letteri, F.

AU - Levi Minzi, G. V.

AU - Lorusso, S.

AU - Ludovico, L.

AU - Luzzi, Simona

AU - Maggiore, Laura

AU - Magnani, Giuseppe

AU - Mancini, G.

AU - Manconi, F. M.

AU - Manfredi, Luigi

AU - Maniscalco, M.

AU - Marano, P.

AU - Marcon, M.

AU - Marcone, A.

AU - Marra, C.

AU - Martorana, A.

AU - Mascia, M. G.

AU - Mascia, V.

AU - Mauri, Margherita

AU - Mazzei, B.

AU - Meloni, M.

AU - Merlo, P.

AU - Messa, G.

AU - Milia, A.

AU - Monacelli, Fiammetta

AU - Montecalvo, G.

AU - Moschella, V.

AU - Mura, G.

AU - Nemni, Raffaello

AU - Nobili, Flavio

AU - Notarelli, Antonella

AU - Di Giacomo, R.

AU - Onofrj, M.

AU - Paci, C.

AU - Padiglioni, Chiara

AU - Perini, M.

AU - Perotta, D.

AU - Perri, F. A.

AU - Perri, Roberta

AU - Piccininni, C.

AU - Piccoli, T.

AU - Pilia, G.

AU - Pilotto, Andrea

AU - Poli, S.

AU - Pomati, Simone

AU - Pompanin, Sara

AU - Pucci, E.

AU - Puccio, Gianfranco

AU - Quaranta, D.

AU - Rainero, Innocenzo

AU - Rea, G.

AU - Realmuto, Sabrina

AU - Riva, M.

AU - Rizzetti, Maria Cristina

AU - Rolma, Giuseppe

AU - Rozzini, L.

AU - Sacco, Leonardo

AU - Saibene, Francesca Lea

AU - Scarpini, Elio Angelo

AU - Sensi, S.

AU - Seripa, Davide

AU - Sinforiani, Elena

AU - Sorbi, S.

AU - Sorrentino, Giuseppe

AU - Spallazzi, Marco

AU - Stracciari, A.

AU - Talarico, G.

AU - Tassinari, Tiziana

AU - Thomas, Astrid

AU - Tiezzi, A.

AU - Tomassini, Pia Francesca

AU - Trebbastoni, Alessandro

AU - Tremolizzo, Lucio

AU - Tripi, G.

AU - Ursini, Francesca

AU - Vaianella, L.

AU - Valluzzi, Francesco

AU - Vezzadini, Giuliana

AU - Vista, M.

AU - Volontè, Maria Antonietta

PY - 2016/9/13

Y1 - 2016/9/13

N2 - Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients’ reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer’s disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 %) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 %) than that of Alzheimer’s disease and frontotemporal dementia (56 ± 27 %) patients. The majority of the centers (91 %) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 %), electroencephalography (EEG; 93 %), and FP-CIT single photon emission-computerized tomography (SPECT; 75 %) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.

AB - Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients’ reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer’s disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 %) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 %) than that of Alzheimer’s disease and frontotemporal dementia (56 ± 27 %) patients. The majority of the centers (91 %) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 %), electroencephalography (EEG; 93 %), and FP-CIT single photon emission-computerized tomography (SPECT; 75 %) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.

KW - Dementia with Lewy bodies

KW - Standardization of diagnostic procedures

KW - Survey

UR - http://www.scopus.com/inward/record.url?scp=84987660259&partnerID=8YFLogxK

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U2 - 10.1007/s10072-016-2713-8

DO - 10.1007/s10072-016-2713-8

M3 - Article

SP - 1

EP - 9

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -