The Italian experience on paediatric liver transplantation: 1988-1999 report

M. Pompili, V. G. Mirante, S. Fagiuoli, S. Beccaria, G. Leandro, G. L. Rapaccini, A. Gasbarrini, R. Naccarato, L. Pagliaro, M. Rizzetto, G. Gasbarrini

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Liver transplantation is the treatment of choice for end-stage liver disease in both adult and paediatric patients. The Italian experience in paediatric liver transplantation during the period 1988-1999 is reported herein. Patients and methods. This report concerns 228 liver transplantations performed in 207 patients (100 male, 107 female, mean age 5.1±4.4 years) in 11 Italian centres. The mean waiting time on the transplantation list was 6.1±8.9 months and the main indications for the procedure were biliary atresia, inborn metabolic disorders, liver cirrhosis, liver neoplasms, Alagille syndrome, and fulminant hepatic failure. Results. The cumulative survival rate was 77%, 76%, 73%, and 71% at 1, 3, 5, and 7 years. The overall prevalence of acute rejection was 54%. Survival was significantly affected by re-transplantation (p=0.0002), by United Network for Organ Sharing 4 status at transplantation (p=0.016), and, among the indications for the procedure, by fulminant hepatic failure (p=0.004). Fifty patients (24%) died during the observation period. The main causes of death were primary non-function of the graft and sepsis Conclusions. This study shows that liver transplantation in paediatric age, in Italy, is an effective procedure providing a 5-year survival rate comparable to that attained in the largest published series.

Original languageEnglish
Pages (from-to)649-655
Number of pages7
JournalDigestive and Liver Disease
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Liver transplantations
  • Paediatric age
  • Survival analysis

ASJC Scopus subject areas

  • Gastroenterology

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