The Italian hemodilution trial in acute stroke

M. Rango, G. Pinardi, C. Fieschi, C. Argentino, F. Giubilei, M. Rasura, S. Cappellari, A. Casazza, L. Grilli, C. P. Warlow, R. Peto, A. Morabito, Ospedale S S Trinità, E. Nardozza, M. Dellasette, A. Mamoli, M. Camerlingo, P. Gambaro, G. D'Alessandro, E. BottacchiL. Garello, P. Piola, G. A. Ottonello, M. Fonzari, L. A. Vignolo, V. Di Monda, D. Vangi, G. Dalla Volta, C. Lazzari, M. Magoni, P. Perrone, D. Porazzi, G. Bonzi, P. Secchi, L. Faggi, E. Donati, L. Callea, L. De Lorenzi, G. Chiodello, G. Galli, M. Guarneri, F. Mironi, P. Previdi, F. Erminio, S. Cappa, R. Sterzi, N. Galbiati, G. Scarlato, L. Candelise, R. Colombo, M. Rango, G. Pinardi, A. Randazzo, F. Porro, G. L. Brambilla, G. Sangiovanni, V. Silvani, P. Fratino, D. Rogledi, M. G. Ranieri, D. Zerbi, A. Gomitoni, C. A. De Fanti, A. Brambilla, L. C. Erli, M. Lozza, S. Tomaiuolo, I. Votta, D. Baldini, M. Montanari, P. Bovi, G. Gambina, L. Deotto, F. Ferro Milone, Andrea P. Parisen, F. Bortolon, O. Ponari, M. Squeri, A. Mombelloni, G. G. Rebucci, G. Bissi, F. Benazzi, D. Inzitari, P. Marini, A. Ginanneschi, P. Nencini, D. Sità, P. Cioni, A. Muratorio, C. Giraldi, A. Martini, L. Valpentesta, A. Viscardi, D. Bizzarri, Ettorre M B Biotti, V. Caterini, G. M. Fabrizi, C. Venturi, L. Provinciali, M. Del Pesce, P. Di Bella, G. Nenci, E. Boschetti, A. Scortecci, M. Taramelli, C. Chiurulla, L. Agostini, S. Ricci, P. Brustenghi, M. G. Scarcella, E. Signorini, U. Senin, G. Aisa, G. Valigi, V. Gallai, F. Santucci, P. Caselli, G. L. Piccinin, M. Ghezzi, A. Bianchi, G. M. Malentacchi, C. Refi, C. Argentino, M. Rasura, F. Giubilei, M. L. Germani, M. L. Sacchetti, D. Gambi, L. Marchionno, L. Aquilone, R. Cutarella, F. Federico, G. Deluca, V. Lucivero, A. Fiore, P. Lamberti, E. Ferrari, L. Sallusto, N. Gigante, A. Calogero, F. Pignatelli, C. Scapati

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Italian Acute Stroke Study is a prospective, multicenter, randomized, clinical trial to evaluate hemodilution in acute stroke. Thirty-one centers will recruit 1,200 patients with a recent (<12 hours) hemispheric acute stroke. Randomization is performed centrally, and patients are stratified by center and severity of neurologic deficit. Hemodilution is achieved by venesection and infusion of the same amount of dextran 40. Otherwise, both treated and control groups receive the standard treatment provided by each center within agreed guidelines. At 6 months after stroke, one member of the Clinical Coordinating Center, blind as to treatment allocation, collects data on mortality and disability by telephone. We expect to terminate the randomization on December 31,1986, and the follow-up evaluation on June 30,1987. The aim of the study is to evaluate whether mortality and disability are significantly reduced in the group treated with hemodilution compared with the control group.

Original languageEnglish
Pages (from-to)670-676
Number of pages7
JournalStroke
Volume18
Issue number3
Publication statusPublished - 1987

Fingerprint

Hemodilution
Stroke
Random Allocation
Control Groups
Phlebotomy
Mortality
Neurologic Manifestations
Dextrans
Telephone
Randomized Controlled Trials
Guidelines
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Cite this

Rango, M., Pinardi, G., Fieschi, C., Argentino, C., Giubilei, F., Rasura, M., ... Scapati, C. (1987). The Italian hemodilution trial in acute stroke. Stroke, 18(3), 670-676.

The Italian hemodilution trial in acute stroke. / Rango, M.; Pinardi, G.; Fieschi, C.; Argentino, C.; Giubilei, F.; Rasura, M.; Cappellari, S.; Casazza, A.; Grilli, L.; Warlow, C. P.; Peto, R.; Morabito, A.; Trinità, Ospedale S S; Nardozza, E.; Dellasette, M.; Mamoli, A.; Camerlingo, M.; Gambaro, P.; D'Alessandro, G.; Bottacchi, E.; Garello, L.; Piola, P.; Ottonello, G. A.; Fonzari, M.; Vignolo, L. A.; Di Monda, V.; Vangi, D.; Dalla Volta, G.; Lazzari, C.; Magoni, M.; Perrone, P.; Porazzi, D.; Bonzi, G.; Secchi, P.; Faggi, L.; Donati, E.; Callea, L.; De Lorenzi, L.; Chiodello, G.; Galli, G.; Guarneri, M.; Mironi, F.; Previdi, P.; Erminio, F.; Cappa, S.; Sterzi, R.; Galbiati, N.; Scarlato, G.; Candelise, L.; Colombo, R.; Rango, M.; Pinardi, G.; Randazzo, A.; Porro, F.; Brambilla, G. L.; Sangiovanni, G.; Silvani, V.; Fratino, P.; Rogledi, D.; Ranieri, M. G.; Zerbi, D.; Gomitoni, A.; De Fanti, C. A.; Brambilla, A.; Erli, L. C.; Lozza, M.; Tomaiuolo, S.; Votta, I.; Baldini, D.; Montanari, M.; Bovi, P.; Gambina, G.; Deotto, L.; Ferro Milone, F.; Parisen, Andrea P.; Bortolon, F.; Ponari, O.; Squeri, M.; Mombelloni, A.; Rebucci, G. G.; Bissi, G.; Benazzi, F.; Inzitari, D.; Marini, P.; Ginanneschi, A.; Nencini, P.; Sità, D.; Cioni, P.; Muratorio, A.; Giraldi, C.; Martini, A.; Valpentesta, L.; Viscardi, A.; Bizzarri, D.; Biotti, Ettorre M B; Caterini, V.; Fabrizi, G. M.; Venturi, C.; Provinciali, L.; Del Pesce, M.; Di Bella, P.; Nenci, G.; Boschetti, E.; Scortecci, A.; Taramelli, M.; Chiurulla, C.; Agostini, L.; Ricci, S.; Brustenghi, P.; Scarcella, M. G.; Signorini, E.; Senin, U.; Aisa, G.; Valigi, G.; Gallai, V.; Santucci, F.; Caselli, P.; Piccinin, G. L.; Ghezzi, M.; Bianchi, A.; Malentacchi, G. M.; Refi, C.; Argentino, C.; Rasura, M.; Giubilei, F.; Germani, M. L.; Sacchetti, M. L.; Gambi, D.; Marchionno, L.; Aquilone, L.; Cutarella, R.; Federico, F.; Deluca, G.; Lucivero, V.; Fiore, A.; Lamberti, P.; Ferrari, E.; Sallusto, L.; Gigante, N.; Calogero, A.; Pignatelli, F.; Scapati, C.

In: Stroke, Vol. 18, No. 3, 1987, p. 670-676.

Research output: Contribution to journalArticle

Rango, M, Pinardi, G, Fieschi, C, Argentino, C, Giubilei, F, Rasura, M, Cappellari, S, Casazza, A, Grilli, L, Warlow, CP, Peto, R, Morabito, A, Trinità, OSS, Nardozza, E, Dellasette, M, Mamoli, A, Camerlingo, M, Gambaro, P, D'Alessandro, G, Bottacchi, E, Garello, L, Piola, P, Ottonello, GA, Fonzari, M, Vignolo, LA, Di Monda, V, Vangi, D, Dalla Volta, G, Lazzari, C, Magoni, M, Perrone, P, Porazzi, D, Bonzi, G, Secchi, P, Faggi, L, Donati, E, Callea, L, De Lorenzi, L, Chiodello, G, Galli, G, Guarneri, M, Mironi, F, Previdi, P, Erminio, F, Cappa, S, Sterzi, R, Galbiati, N, Scarlato, G, Candelise, L, Colombo, R, Rango, M, Pinardi, G, Randazzo, A, Porro, F, Brambilla, GL, Sangiovanni, G, Silvani, V, Fratino, P, Rogledi, D, Ranieri, MG, Zerbi, D, Gomitoni, A, De Fanti, CA, Brambilla, A, Erli, LC, Lozza, M, Tomaiuolo, S, Votta, I, Baldini, D, Montanari, M, Bovi, P, Gambina, G, Deotto, L, Ferro Milone, F, Parisen, AP, Bortolon, F, Ponari, O, Squeri, M, Mombelloni, A, Rebucci, GG, Bissi, G, Benazzi, F, Inzitari, D, Marini, P, Ginanneschi, A, Nencini, P, Sità, D, Cioni, P, Muratorio, A, Giraldi, C, Martini, A, Valpentesta, L, Viscardi, A, Bizzarri, D, Biotti, EMB, Caterini, V, Fabrizi, GM, Venturi, C, Provinciali, L, Del Pesce, M, Di Bella, P, Nenci, G, Boschetti, E, Scortecci, A, Taramelli, M, Chiurulla, C, Agostini, L, Ricci, S, Brustenghi, P, Scarcella, MG, Signorini, E, Senin, U, Aisa, G, Valigi, G, Gallai, V, Santucci, F, Caselli, P, Piccinin, GL, Ghezzi, M, Bianchi, A, Malentacchi, GM, Refi, C, Argentino, C, Rasura, M, Giubilei, F, Germani, ML, Sacchetti, ML, Gambi, D, Marchionno, L, Aquilone, L, Cutarella, R, Federico, F, Deluca, G, Lucivero, V, Fiore, A, Lamberti, P, Ferrari, E, Sallusto, L, Gigante, N, Calogero, A, Pignatelli, F & Scapati, C 1987, 'The Italian hemodilution trial in acute stroke', Stroke, vol. 18, no. 3, pp. 670-676.
Rango M, Pinardi G, Fieschi C, Argentino C, Giubilei F, Rasura M et al. The Italian hemodilution trial in acute stroke. Stroke. 1987;18(3):670-676.
Rango, M. ; Pinardi, G. ; Fieschi, C. ; Argentino, C. ; Giubilei, F. ; Rasura, M. ; Cappellari, S. ; Casazza, A. ; Grilli, L. ; Warlow, C. P. ; Peto, R. ; Morabito, A. ; Trinità, Ospedale S S ; Nardozza, E. ; Dellasette, M. ; Mamoli, A. ; Camerlingo, M. ; Gambaro, P. ; D'Alessandro, G. ; Bottacchi, E. ; Garello, L. ; Piola, P. ; Ottonello, G. A. ; Fonzari, M. ; Vignolo, L. A. ; Di Monda, V. ; Vangi, D. ; Dalla Volta, G. ; Lazzari, C. ; Magoni, M. ; Perrone, P. ; Porazzi, D. ; Bonzi, G. ; Secchi, P. ; Faggi, L. ; Donati, E. ; Callea, L. ; De Lorenzi, L. ; Chiodello, G. ; Galli, G. ; Guarneri, M. ; Mironi, F. ; Previdi, P. ; Erminio, F. ; Cappa, S. ; Sterzi, R. ; Galbiati, N. ; Scarlato, G. ; Candelise, L. ; Colombo, R. ; Rango, M. ; Pinardi, G. ; Randazzo, A. ; Porro, F. ; Brambilla, G. L. ; Sangiovanni, G. ; Silvani, V. ; Fratino, P. ; Rogledi, D. ; Ranieri, M. G. ; Zerbi, D. ; Gomitoni, A. ; De Fanti, C. A. ; Brambilla, A. ; Erli, L. C. ; Lozza, M. ; Tomaiuolo, S. ; Votta, I. ; Baldini, D. ; Montanari, M. ; Bovi, P. ; Gambina, G. ; Deotto, L. ; Ferro Milone, F. ; Parisen, Andrea P. ; Bortolon, F. ; Ponari, O. ; Squeri, M. ; Mombelloni, A. ; Rebucci, G. G. ; Bissi, G. ; Benazzi, F. ; Inzitari, D. ; Marini, P. ; Ginanneschi, A. ; Nencini, P. ; Sità, D. ; Cioni, P. ; Muratorio, A. ; Giraldi, C. ; Martini, A. ; Valpentesta, L. ; Viscardi, A. ; Bizzarri, D. ; Biotti, Ettorre M B ; Caterini, V. ; Fabrizi, G. M. ; Venturi, C. ; Provinciali, L. ; Del Pesce, M. ; Di Bella, P. ; Nenci, G. ; Boschetti, E. ; Scortecci, A. ; Taramelli, M. ; Chiurulla, C. ; Agostini, L. ; Ricci, S. ; Brustenghi, P. ; Scarcella, M. G. ; Signorini, E. ; Senin, U. ; Aisa, G. ; Valigi, G. ; Gallai, V. ; Santucci, F. ; Caselli, P. ; Piccinin, G. L. ; Ghezzi, M. ; Bianchi, A. ; Malentacchi, G. M. ; Refi, C. ; Argentino, C. ; Rasura, M. ; Giubilei, F. ; Germani, M. L. ; Sacchetti, M. L. ; Gambi, D. ; Marchionno, L. ; Aquilone, L. ; Cutarella, R. ; Federico, F. ; Deluca, G. ; Lucivero, V. ; Fiore, A. ; Lamberti, P. ; Ferrari, E. ; Sallusto, L. ; Gigante, N. ; Calogero, A. ; Pignatelli, F. ; Scapati, C. / The Italian hemodilution trial in acute stroke. In: Stroke. 1987 ; Vol. 18, No. 3. pp. 670-676.
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abstract = "The Italian Acute Stroke Study is a prospective, multicenter, randomized, clinical trial to evaluate hemodilution in acute stroke. Thirty-one centers will recruit 1,200 patients with a recent (<12 hours) hemispheric acute stroke. Randomization is performed centrally, and patients are stratified by center and severity of neurologic deficit. Hemodilution is achieved by venesection and infusion of the same amount of dextran 40. Otherwise, both treated and control groups receive the standard treatment provided by each center within agreed guidelines. At 6 months after stroke, one member of the Clinical Coordinating Center, blind as to treatment allocation, collects data on mortality and disability by telephone. We expect to terminate the randomization on December 31,1986, and the follow-up evaluation on June 30,1987. The aim of the study is to evaluate whether mortality and disability are significantly reduced in the group treated with hemodilution compared with the control group.",
author = "M. Rango and G. Pinardi and C. Fieschi and C. Argentino and F. Giubilei and M. Rasura and S. Cappellari and A. Casazza and L. Grilli and Warlow, {C. P.} and R. Peto and A. Morabito and Trinit{\`a}, {Ospedale S S} and E. Nardozza and M. Dellasette and A. Mamoli and M. Camerlingo and P. Gambaro and G. D'Alessandro and E. Bottacchi and L. Garello and P. Piola and Ottonello, {G. A.} and M. Fonzari and Vignolo, {L. A.} and {Di Monda}, V. and D. Vangi and {Dalla Volta}, G. and C. Lazzari and M. Magoni and P. Perrone and D. Porazzi and G. Bonzi and P. Secchi and L. Faggi and E. Donati and L. Callea and {De Lorenzi}, L. and G. Chiodello and G. Galli and M. Guarneri and F. Mironi and P. Previdi and F. Erminio and S. Cappa and R. Sterzi and N. Galbiati and G. Scarlato and L. Candelise and R. Colombo and M. Rango and G. Pinardi and A. Randazzo and F. Porro and Brambilla, {G. L.} and G. Sangiovanni and V. Silvani and P. Fratino and D. Rogledi and Ranieri, {M. G.} and D. Zerbi and A. Gomitoni and {De Fanti}, {C. A.} and A. Brambilla and Erli, {L. C.} and M. Lozza and S. Tomaiuolo and I. Votta and D. Baldini and M. Montanari and P. Bovi and G. Gambina and L. Deotto and {Ferro Milone}, F. and Parisen, {Andrea P.} and F. Bortolon and O. Ponari and M. Squeri and A. Mombelloni and Rebucci, {G. G.} and G. Bissi and F. Benazzi and D. Inzitari and P. Marini and A. Ginanneschi and P. Nencini and D. Sit{\`a} and P. Cioni and A. Muratorio and C. Giraldi and A. Martini and L. Valpentesta and A. Viscardi and D. Bizzarri and Biotti, {Ettorre M B} and V. Caterini and Fabrizi, {G. M.} and C. Venturi and L. Provinciali and {Del Pesce}, M. and {Di Bella}, P. and G. Nenci and E. Boschetti and A. Scortecci and M. Taramelli and C. Chiurulla and L. Agostini and S. Ricci and P. Brustenghi and Scarcella, {M. G.} and E. Signorini and U. Senin and G. Aisa and G. Valigi and V. Gallai and F. Santucci and P. Caselli and Piccinin, {G. L.} and M. Ghezzi and A. Bianchi and Malentacchi, {G. M.} and C. Refi and C. Argentino and M. Rasura and F. Giubilei and Germani, {M. L.} and Sacchetti, {M. L.} and D. Gambi and L. Marchionno and L. Aquilone and R. Cutarella and F. Federico and G. Deluca and V. Lucivero and A. Fiore and P. Lamberti and E. Ferrari and L. Sallusto and N. Gigante and A. Calogero and F. Pignatelli and C. Scapati",
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TY - JOUR

T1 - The Italian hemodilution trial in acute stroke

AU - Rango, M.

AU - Pinardi, G.

AU - Fieschi, C.

AU - Argentino, C.

AU - Giubilei, F.

AU - Rasura, M.

AU - Cappellari, S.

AU - Casazza, A.

AU - Grilli, L.

AU - Warlow, C. P.

AU - Peto, R.

AU - Morabito, A.

AU - Trinità, Ospedale S S

AU - Nardozza, E.

AU - Dellasette, M.

AU - Mamoli, A.

AU - Camerlingo, M.

AU - Gambaro, P.

AU - D'Alessandro, G.

AU - Bottacchi, E.

AU - Garello, L.

AU - Piola, P.

AU - Ottonello, G. A.

AU - Fonzari, M.

AU - Vignolo, L. A.

AU - Di Monda, V.

AU - Vangi, D.

AU - Dalla Volta, G.

AU - Lazzari, C.

AU - Magoni, M.

AU - Perrone, P.

AU - Porazzi, D.

AU - Bonzi, G.

AU - Secchi, P.

AU - Faggi, L.

AU - Donati, E.

AU - Callea, L.

AU - De Lorenzi, L.

AU - Chiodello, G.

AU - Galli, G.

AU - Guarneri, M.

AU - Mironi, F.

AU - Previdi, P.

AU - Erminio, F.

AU - Cappa, S.

AU - Sterzi, R.

AU - Galbiati, N.

AU - Scarlato, G.

AU - Candelise, L.

AU - Colombo, R.

AU - Rango, M.

AU - Pinardi, G.

AU - Randazzo, A.

AU - Porro, F.

AU - Brambilla, G. L.

AU - Sangiovanni, G.

AU - Silvani, V.

AU - Fratino, P.

AU - Rogledi, D.

AU - Ranieri, M. G.

AU - Zerbi, D.

AU - Gomitoni, A.

AU - De Fanti, C. A.

AU - Brambilla, A.

AU - Erli, L. C.

AU - Lozza, M.

AU - Tomaiuolo, S.

AU - Votta, I.

AU - Baldini, D.

AU - Montanari, M.

AU - Bovi, P.

AU - Gambina, G.

AU - Deotto, L.

AU - Ferro Milone, F.

AU - Parisen, Andrea P.

AU - Bortolon, F.

AU - Ponari, O.

AU - Squeri, M.

AU - Mombelloni, A.

AU - Rebucci, G. G.

AU - Bissi, G.

AU - Benazzi, F.

AU - Inzitari, D.

AU - Marini, P.

AU - Ginanneschi, A.

AU - Nencini, P.

AU - Sità, D.

AU - Cioni, P.

AU - Muratorio, A.

AU - Giraldi, C.

AU - Martini, A.

AU - Valpentesta, L.

AU - Viscardi, A.

AU - Bizzarri, D.

AU - Biotti, Ettorre M B

AU - Caterini, V.

AU - Fabrizi, G. M.

AU - Venturi, C.

AU - Provinciali, L.

AU - Del Pesce, M.

AU - Di Bella, P.

AU - Nenci, G.

AU - Boschetti, E.

AU - Scortecci, A.

AU - Taramelli, M.

AU - Chiurulla, C.

AU - Agostini, L.

AU - Ricci, S.

AU - Brustenghi, P.

AU - Scarcella, M. G.

AU - Signorini, E.

AU - Senin, U.

AU - Aisa, G.

AU - Valigi, G.

AU - Gallai, V.

AU - Santucci, F.

AU - Caselli, P.

AU - Piccinin, G. L.

AU - Ghezzi, M.

AU - Bianchi, A.

AU - Malentacchi, G. M.

AU - Refi, C.

AU - Argentino, C.

AU - Rasura, M.

AU - Giubilei, F.

AU - Germani, M. L.

AU - Sacchetti, M. L.

AU - Gambi, D.

AU - Marchionno, L.

AU - Aquilone, L.

AU - Cutarella, R.

AU - Federico, F.

AU - Deluca, G.

AU - Lucivero, V.

AU - Fiore, A.

AU - Lamberti, P.

AU - Ferrari, E.

AU - Sallusto, L.

AU - Gigante, N.

AU - Calogero, A.

AU - Pignatelli, F.

AU - Scapati, C.

PY - 1987

Y1 - 1987

N2 - The Italian Acute Stroke Study is a prospective, multicenter, randomized, clinical trial to evaluate hemodilution in acute stroke. Thirty-one centers will recruit 1,200 patients with a recent (<12 hours) hemispheric acute stroke. Randomization is performed centrally, and patients are stratified by center and severity of neurologic deficit. Hemodilution is achieved by venesection and infusion of the same amount of dextran 40. Otherwise, both treated and control groups receive the standard treatment provided by each center within agreed guidelines. At 6 months after stroke, one member of the Clinical Coordinating Center, blind as to treatment allocation, collects data on mortality and disability by telephone. We expect to terminate the randomization on December 31,1986, and the follow-up evaluation on June 30,1987. The aim of the study is to evaluate whether mortality and disability are significantly reduced in the group treated with hemodilution compared with the control group.

AB - The Italian Acute Stroke Study is a prospective, multicenter, randomized, clinical trial to evaluate hemodilution in acute stroke. Thirty-one centers will recruit 1,200 patients with a recent (<12 hours) hemispheric acute stroke. Randomization is performed centrally, and patients are stratified by center and severity of neurologic deficit. Hemodilution is achieved by venesection and infusion of the same amount of dextran 40. Otherwise, both treated and control groups receive the standard treatment provided by each center within agreed guidelines. At 6 months after stroke, one member of the Clinical Coordinating Center, blind as to treatment allocation, collects data on mortality and disability by telephone. We expect to terminate the randomization on December 31,1986, and the follow-up evaluation on June 30,1987. The aim of the study is to evaluate whether mortality and disability are significantly reduced in the group treated with hemodilution compared with the control group.

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JO - Stroke

JF - Stroke

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