The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry

Serena Merante, Virginia V. Ferretti, Chiara Elena, Valeria Brazzelli, Roberta Zanotti, Iria Ner, Diomira Magliacane, Anna Belloni Fortina, Forer Ingeborg, Elide A. Pastorello, Lisa Pieri, Cristina Papayannidis, Marina Mauro, Federica Grifoni, Roberto Minelli, Elena Guggiari, Elisa Difonzo, Monica Bocchia, Francesca Caroppo, Sergio Di NuzzoElena Maria Elli, Michela Rondoni, Rachele Ciccocioppo, Michele Di Stefano, Grazia Bossi, Emanuela Boveri, Patrizia Bonadonna, Fiorina Giona, Peter Valent, Massimo Triggiani

Research output: Contribution to journalArticle

Abstract

Aim: We collected 'real-life' data on the management of patients with mastocytosis in the Italian Mastocytosis Registry. Methods: Six hundred patients diagnosed with mastocytosis between 1974 and 2014 were included from 19 centers. Results: Among adults (n = 401); 156 (38.9%) patients were diagnosed with systemic mastocytosis. In 212 adults, no bone marrow studies were performed resulting in a provisional diagnosis of mastocytosis of the skin. This diagnosis was most frequently established in nonhematologic centers. In total, 182/184 pediatric patients had cutaneous mastocytosis. We confirmed that in the most patients with systemic mastocytosis, serum tryptase levels were >20 ng/ml and KIT D816V was detectable. Conclusion: The Italian Mastocytosis Registry revealed some center-specific approaches for diagnosis and therapy. Epidemiological evidence on this condition is provided.

Original languageEnglish
Pages (from-to)2713-2723
Number of pages11
JournalFuture Oncology
Volume14
Issue number26
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • hospital-based registry
  • mastocytosis
  • multidisciplinary management

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Merante, S., Ferretti, V. V., Elena, C., Brazzelli, V., Zanotti, R., Ner, I., Magliacane, D., Belloni Fortina, A., Ingeborg, F., Pastorello, E. A., Pieri, L., Papayannidis, C., Mauro, M., Grifoni, F., Minelli, R., Guggiari, E., Difonzo, E., Bocchia, M., Caroppo, F., ... Triggiani, M. (2018). The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry. Future Oncology, 14(26), 2713-2723. https://doi.org/10.2217/fon-2018-0291