The Italian registry of aggressive rheumatoid arthritis - The GIARA project

Antonio Marchesoni, Marcello Govoni, Gabriele Valentini, Guido Valesini, Fausto Salaffi, Pierluigi Macchioni, Ornella Della Casa Alberighi, Gianfranco Ferraccioli, A. Accardi, S. Adami, G. Arioli, G. Bagnato, L. M. Bambara, G. Bianchi, S. Bombardieri, M. Broggini, E. Cacace, E. Califano, N. Campaniello, B. CanesiR. Carignola, G. Carniello, M. Carrabba, G. Cassisi, M. L. Ciompi, P. Clerico, S. Coaccioli, C. Concesi, G. Consonni, S. Corsaro, C. Davoli, A. De Cata, M. Del Frate, G. Della Corte, P. Di Giuseppe, L. Di Matteo, M. Diamanti, L. Evangelista, P. Fietta, M. Fusconi, A. Gabrielli, M. Gardinali, M. Ghirardini, R. Giacomelli, R. Gorla, R. Gusi, F. La Palombara, G. Lapadula, M. Leone, M. Limonta, R. Lo Gulfo, C. Lovino, P. Manganelli, D. Mantova, P. G. Marello, F. Martini, M. T. Mascia, C. Mastaglio, A. Mathieu, L. Mattara, M. Matucci, G. Mazzanto, C. Meschini, A. Migliore, G. Minisola, V. Modena, P. Morassi, M. Muratore, G. Nuvoli, I. Olivieri, P. Oriente, P. Ostuni, G. Paolazzi, R. Pellerito, G. Peronato, G. Pistone, G. Provenzano, A. Pucino, M. Pusceddu, G. Raffa, R. Rigotti, M. Rondana, R. Russo, L. Sabadini, M. G. Sabbattini, P. Scapato, S. Scarpato, G. D. Sebastiani, K. Steinhauser, G. Tocci, R. Torre, G. Triolo, A. Trotta, V. Vinicola, C. Vitali, D. Volante

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. In 1999, the Italian Society of Rheumatology started a project to determine the prevalence and clinical characteristics of aggressive rheumatoid arthritis (ARA). Methods. For 1 year, all patients with RA for <5 years and referred to participating centers were entered in a registry and classified as having ARA if they fulfilled the following criteria: 10 swollen joints for at least 6 weeks, positive rheumatoid factor (RF), and at least one bone erosion (if disease duration of 2 years); (a) RF-positive and having 10 swollen joints or at least one newly eroded joint, or (b) if RF-negative, having 10 swollen joints and at least one newly eroded joint (if disease duration > 2 to <5 years). Results. The 94 participating centers enrolled 1218 patients with RA, 1130 of whom had enough data to be classified as ARA (29.0%) or non-ARA (71.0%). The frequency of ARA was 15% in the 2-year group and 63% in the > 2 to <5-year group, but 35% of the patients in the 2-year group had erosions. Bone erosions were associated with disease duration, a Health Assessment Questionnaire value > 1.5, female sex, and RF positivity. Conditions other than RA were recorded in about 50% of the patients, and only 30%-40% were taking disease modifying antirheumatic drugs. Conclusion. In an Italian RA population, the GIARA (Gruppo Italiano Artrite Reumatoide Aggressiva) criteria for ARA were met by 15% of the patients with disease duration of 2 years, but erosions were seen in 35%. Upon referral, most of the RA patients were inadequately treated and had other conditions.

Original languageEnglish
Pages (from-to)2374-2381
Number of pages8
JournalJournal of Rheumatology
Volume34
Issue number12
Publication statusPublished - Dec 2007

Keywords

  • Bone erosion
  • Early arthritis
  • Registries
  • Rheumatoid arthritis
  • Severity

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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