The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients

Salvatore Mangiafico, Giovanni Pracucci, Valentina Saia, Patrizia Nencini, Domenico Inzitari, Sergio Nappini, Stefano Vallone, Andrea Zini, Maurizio Fuschi, Davide Cerone, Mauro Bergui, Paolo Cerrato, Roberto Gandini, Fabrizio Sallustio, Andrea Saletti, Alessandro De Vito, Daniele G. Romano, Rossana Tassi, Francesco Causin, Claudio BaracchiniMariangela Piano, Cristina Motto, Alfonso Ciccone, Roberto Gasparotti, Mauro Magoni, Andrea Giorgianni, Marialuisa DeLodovici, Nicola Cavasin, Adriana Critelli, Massimo Gallucci, Antonio Carolei, Teodoro Meloni, Giovanni Corso, Giacomo Vaudano, Enrica Duc, Federico Zappoli, Anna Cavallini, Riccardo Padolecchia, Tiziana Tassinari, Marco Longoni, Andrea Salmaggi, PierGiuseppe G. Zampieri, Paolo Bovi, Michele Puglioli, Alberto Chiti, Giulio Guidetti, Luigi Simonetti, Gaetano Procaccianti, Roberto Menozzi, Umberto Scoditti, Fabrizio Ricciardi, Francesca R. Pezzella, Gianluigi Guarnieri, Vincenzo Andreone, Danilo Toni

Research output: Contribution to journalArticle


Endovascular treatment (ET) showed to be safe in acute stroke, but its superiority over intravenous thrombolysis is debated. As ET is rapidly evolving, it is not clear which role it may deserve in the future of stoke treatments. Based on an observational design, a treatment registry allows to study a broad range of patients, turning into a powerful tool for patients’ selection. We report the methodology and a descriptive analysis of patients from a national registry of ET for stroke. The Italian Registry of Endovascular Treatment in Acute Stroke is a multicenter, observational registry running in Italy from 2010. All patients treated with ET in the participating centers were consecutively recorded. Safety measures were symptomatic intracranial hemorrhage, procedural adverse events and death rate. Efficacy measures were arterial recanalization and 3-month good functional outcome. From 2008 to 2012, 960 patients were treated in 25 centers. Median age was 67 years, male gender 57 %. Median baseline NIHSS was 17. The most frequent occlusion site was Middle cerebral artery (46.9 %). Intra-arterial thrombolytics were used in 165 (17.9 %) patients, in 531 (57.5 %) thrombectomy was employed, and 228 (24.7 %) patients received both treatments. Baseline features of this cohort are in line with data from large clinical series and recent trials. This registry allows to collect data from a real practice scenario and to highlight time trends in treatment modalities. It can address unsolved safety and efficacy issues on ET of stroke, providing a useful tool for the planning of new trials.

Original languageEnglish
Pages (from-to)985-993
Number of pages9
JournalNeurological Sciences
Issue number6
Publication statusPublished - Jun 5 2015


  • Acute ischemic stroke
  • Acute stroke therapy
  • Endovascular treatment
  • Registry design

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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    Mangiafico, S., Pracucci, G., Saia, V., Nencini, P., Inzitari, D., Nappini, S., Vallone, S., Zini, A., Fuschi, M., Cerone, D., Bergui, M., Cerrato, P., Gandini, R., Sallustio, F., Saletti, A., De Vito, A., Romano, D. G., Tassi, R., Causin, F., ... Toni, D. (2015). The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients. Neurological Sciences, 36(6), 985-993.