The ITMIG/IASLC thymic epithelial tumors staging project: A proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors

Faiz Y. Bhora, David J. Chen, Frank C. Detterbeck, Hisao Asamura, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, James Huang, Jhingook Kim, Kazuya Kondo, Marco Lucchi, Mirella Marino, Edith M. Marom, Andrew G. Nicholson, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Peter Goldstraw, Ramón Rami-Porta, David BallDavid Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, Catherine Kennedy, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Jan Van Meerbeeck, Alan Mitchell, Takashi Nakano, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Valerie Rusch, Nagahiro Saijo, Jean Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Eugene Blackstone

Research output: Contribution to journalArticle

Abstract

Although the presence of nodal disease is prognostic in thymic malignancy, the significance of the extent of nodal disease has yet to be defined. Lymph node dissection has not been routinely performed, and there is currently no node map defined for thymic malignancy. To establish a universal language for reporting as well as characterize the staging of this disease more accurately, an empiric node map is proposed here. This was developed using prior classification systems, series reporting specifics of nodal involvement, anatomical studies of lymphatic drainage, and preexisting node maps of the chest as defined by the International Association for the Study of Lung Cancer and the neck as defined by the American Academy of Otolaryngology - Head and Neck Surgery and the American Society for Head and Neck Surgery. The development of this node map was a joint effort by the International Thymic Malignancy Interest Group and the Thymic Domain of the IASLC Staging and Prognostic Factors Committee. It was reviewed and subsequently approved by the members of ITMIG. This map will be used as an adjunct to define node staging as part of a universal stage classification for thymic malignancy. As more data are gathered using definitions set forth by this node map, a revision may be undertaken in the future.

Original languageEnglish
Pages (from-to)S88-S96
JournalJournal of Thoracic Oncology
Volume9
Issue number9
Publication statusPublished - Sep 1 2014

Keywords

  • Anterior mediastinal node map
  • Anterior mediastinal nodes
  • ITMIG
  • Thymic carcinoma
  • Thymic malignancy
  • Thymic neuroendocrine tumor
  • Thymic node map
  • Thymoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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    Bhora, F. Y., Chen, D. J., Detterbeck, F. C., Asamura, H., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kim, J., Kondo, K., Lucchi, M., Marino, M., Marom, E. M., Nicholson, A. G., Okumura, M., Ruffini, E., Van Schil, P., Goldstraw, P., Rami-Porta, R., ... Blackstone, E. (2014). The ITMIG/IASLC thymic epithelial tumors staging project: A proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors. Journal of Thoracic Oncology, 9(9), S88-S96.